Effects of dietary scFOS on immunoglobulins in colostrums and milk of bitches.

Fructo-oligosaccharides (scFOS) are prebiotic ingredients that improve protection against pathogens probably through promoting the growth of gastrointestinal bacteria-like Bifidobacteria and Lactobacilli: this stimulation may lead to a better development of immune repertoire and/or stimulation of the local immune response. According to the existence of the immune entero-mammary link, we were wondering if the dietary supplementation with scFOS could enhance the mucosal immunoglobulin level in mammary secretions. Results in this study show that bitches supplemented with scFOS exhibit higher colostrum and milk IgM content without concomitant effect on IgG1, IgG2 and IgA. In addition, intranasally immunized puppies exhibited a trend to higher Bordetella bronchiseptica-specific IgM immune response. The dietary supplementation with scFOS increased the IgM level in colostrums and milk of bitches by mechanisms which remain to be elucidated.

[1]  G. Fahey,et al.  Molecular monitoring and characterization of the faecal microbiota of healthy dogs during fructan supplementation. , 2005, FEMS microbiology letters.

[2]  M. Roberfroid,et al.  Dietary modulation of the human colonic microbiota: updating the concept of prebiotics , 2004, Nutrition Research Reviews.

[3]  G. Gibson,et al.  Modulation of anti‐pathogenic activity in canine‐derived Lactobacillus species by carbohydrate growth substrate , 2004, Journal of applied microbiology.

[4]  H. Salmon.  Immunophysiology of the mammary gland and transmission of immunity to the young. , 2003, Reproduction, nutrition, development.

[5]  C. Grieshop,et al.  Nutrient digestibilities, microbial populations, and protein catabolites as affected by fructan supplementation of dog diets. , 2003, Journal of animal science.

[6]  B. White,et al.  Fermentable fiber reduces recovery time and improves intestinal function in piglets following Salmonella typhimurium infection. , 2003, The Journal of nutrition.

[7]  C. Grieshop,et al.  Fructooligosaccharides and Lactobacillus acidophilus modify gut microbial populations, total tract nutrient digestibilities and fecal protein catabolite concentrations in healthy adult dogs. , 2002, The Journal of nutrition.

[8]  M. Collins,et al.  Bacteriology of the Labrador dog gut: a cultural and genotypic approach , 2002, Journal of applied microbiology.

[9]  A. Beynen,et al.  Faecal bacterial profile, nitrogen excretion and mineral absorption in healthy dogs fed supplemental oligofructose. , 2002, Journal of animal physiology and animal nutrition.

[10]  C. Grieshop,et al.  Supplemental fructooligosaccharides and mannanoligosaccharides influence immune function, ileal and total tract nutrient digestibilities, microbial populations and concentrations of protein catabolites in the large bowel of dogs. , 2002, The Journal of nutrition.

[11]  K. Rhee,et al.  Intestinal Microflora and Diversification of the Rabbit Antibody Repertoire1 , 2000, The Journal of Immunology.

[12]  H. Salmon.  Mammary gland immunology and neonate protection in pigs. Homing of lymphocytes into the MG. , 2000, Advances in experimental medicine and biology.

[13]  M. McBurney,et al.  The fermentable fiber content of the diet alters the function and composition of canine gut associated lymphoid tissue. , 1999, Veterinary immunology and immunopathology.

[14]  H. Salmon,et al.  The mammary gland and neonate mucosal immunity. , 1999, Veterinary immunology and immunopathology.

[15]  C. Chevaleyre,et al.  Differential Recruitment of T- and IgA B-lymphocytes in the Developing Mammary Gland in Relation to Homing Receptors and Vascular Addressins , 1999, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[16]  M. McBurney,et al.  Nutrient Requirements and Interactions Fermentable Dietary Fiber Increases GLP-1 Secretion and Improves Glucose Homeostasis Despite Increased Intestinal Glucose Transport Capacity in Healthy Dogs , 1998 .