A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells.
暂无分享,去创建一个
S. Gygi | M. Vidal | P. Braun | H. Widlund | J. Chick | P. Sicinski | Y. J. Choi | P. Hydbring | Huili Zhai | L. Anders | N. Ke
[1] E. Knudsen,et al. Therapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure , 2010, Oncogene.
[2] M. Barbacid,et al. A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. , 2010, Cancer cell.
[3] P. Deloukas,et al. Signatures of mutation and selection in the cancer genome , 2010, Nature.
[4] Derek Y. Chiang,et al. The landscape of somatic copy-number alteration across human cancers , 2010, Nature.
[5] N. Hay,et al. FoxM1, a critical regulator of oxidative stress during oncogenesis , 2009, The EMBO journal.
[6] J. Hartman,et al. FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer. , 2009, International journal of oncology.
[7] S. Haferkamp,et al. p16INK4a-induced senescence is disabled by melanoma-associated mutations , 2008, Aging cell.
[8] R. Medema,et al. FoxM1 is degraded at mitotic exit in a Cdh1-dependent manner , 2008, Cell cycle.
[9] A. Tyner,et al. FoxM1 Regulates Transcription of JNK1 to Promote the G1/S Transition and Tumor Cell Invasiveness* , 2008, Journal of Biological Chemistry.
[10] S. Mohammed,et al. Activation of FoxM1 during G2 Requires Cyclin A/Cdk-Dependent Relief of Autorepression by the FoxM1 N-Terminal Domain , 2008, Molecular and Cellular Biology.
[11] Douglas S. Darling,et al. Zeb1 links epithelial-mesenchymal transition and cellular senescence , 2008, Development.
[12] S. Mohammed,et al. Activation of FoxM 1 during G 2 Requires Cyclin A / Cdk-Dependent Relief of Autorepression by the FoxM 1 N-Terminal Domain † , 2008 .
[13] J. Campisi,et al. Cellular senescence: when bad things happen to good cells , 2007, Nature Reviews Molecular Cell Biology.
[14] Dean W. Felsher,et al. Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation , 2007, Proceedings of the National Academy of Sciences.
[15] G. Peters,et al. CDK4 and CDK6 Delay Senescence by Kinase-Dependent and p16INK4a-Independent Mechanisms , 2007, Molecular and Cellular Biology.
[16] Amanda M. Ackermann,et al. Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion. , 2007, Journal of molecular endocrinology.
[17] Raymond Sawaya,et al. FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells. , 2006, Cancer research.
[18] B. Lüscher,et al. Regulation of the transcription factor FOXM1c by Cyclin E/CDK2 , 2006, FEBS letters.
[19] I. Wierstra,et al. Transcription factor FOXM1c is repressed by RB and activated by cyclin D1/Cdk4 , 2006, Biological chemistry.
[20] Yan Geng,et al. Requirement for CDK4 kinase function in breast cancer. , 2006, Cancer cell.
[21] Tiansen Li,et al. Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis. , 2006, Cancer cell.
[22] Vladimir Petrovic,et al. Forkhead Box M1 Regulates the Transcriptional Network of Genes Essential for Mitotic Progression and Genes Encoding the SCF (Skp2-Cks1) Ubiquitin Ligase , 2005, Molecular and Cellular Biology.
[23] T. Golub,et al. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma , 2005, Nature.
[24] Hans Clevers,et al. FoxM1 is required for execution of the mitotic programme and chromosome stability , 2005, Nature Cell Biology.
[25] N. Pryer,et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. , 2004, Molecular cancer therapeutics.
[26] K. Helin,et al. E2F target genes: unraveling the biology. , 2004, Trends in biochemical sciences.
[27] A. Datta,et al. Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor. , 2004, Genes & development.
[28] Robert H. Costa,et al. Forkhead Box M1B Transcriptional Activity Requires Binding of Cdk-Cyclin Complexes for Phosphorylation-Dependent Recruitment of p300/CBP Coactivators , 2004, Molecular and Cellular Biology.
[29] K. Shokat,et al. Targets of the cyclin-dependent kinase Cdk1 , 2003, Nature.
[30] Michael B. Yaffe,et al. Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs , 2003, Nucleic Acids Res..
[31] H. Kiyokawa,et al. The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[32] A. Gudkov,et al. Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence. , 2002, Genes & development.
[33] M. Noble,et al. Reversal of Growth Suppression by p107 via Direct Phosphorylation by Cyclin D1/Cyclin-Dependent Kinase 4 , 2002, Molecular and Cellular Biology.
[34] M. Barbacid,et al. Cyclin D-dependent kinases, INK4 inhibitors and cancer. , 2002, Biochimica et biophysica acta.
[35] Yanhui Hu,et al. Proteome-scale purification of human proteins from bacteria , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[36] James M. Roberts,et al. CDK inhibitors: positive and negative regulators of G1-phase progression. , 1999, Genes & development.
[37] G. Peters,et al. The p16INK4a/CDKN2A tumor suppressor and its relatives. , 1998, Biochimica et biophysica acta.
[38] Zhou Songyang,et al. Use of an oriented peptide library to determine the optimal substrates of protein kinases , 1994, Current Biology.