Cholesteryl Ester Transfer Protein and Atherogenesis

The cholesteryl ester transfer protein (CETP) is a hydrophobic M, 70,000 glycoprotein that mediates the transfer and exchange of neutral lipids and phospholipids between the plasma lipoproteins.] The CETP mediates the exchange of HDL CE with the triglycerides of triglyeride-rich lipoproteins (TRL), and thereby enhances the overall catabolism of HDL CE.’ In human genetic CETP deficiency, HDL CE and apoA-I levels are Two common CETP gene mutations have been described in the

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