Tissue-nonspecific alkaline phosphatase is an anti-inflammatory nucleotidase.

[1]  O. Martínez-Augustin,et al.  Experimental acute pancreatitis is enhanced in mice with tissue nonspecific alkaline phoshatase haplodeficiency due to modulation of neutrophils and acinar cells. , 2018, Biochimica et biophysica acta. Molecular basis of disease.

[2]  Yan Jin,et al.  Alpl prevents bone ageing sensitivity by specifically regulating senescence and differentiation in mesenchymal stem cells , 2018, Bone Research.

[3]  Pier Andrea Borea,et al.  Pharmacology of Adenosine Receptors: The State of the Art. , 2018, Physiological reviews.

[4]  S. Mohan,et al.  The art of building bone: emerging role of chondrocyte-to-osteoblast transdifferentiation in endochondral ossification , 2018, Bone Research.

[5]  P. Ciancaglini,et al.  Matrix vesicles from chondrocytes and osteoblasts: Their biogenesis, properties, functions and biomimetic models. , 2018, Biochimica et biophysica acta. General subjects.

[6]  P. Ferguson,et al.  Chronic Recurrent Multifocal Osteomyelitis (CRMO): Presentation, Pathogenesis, and Treatment , 2017, Current Osteoporosis Reports.

[7]  C. Bougault,et al.  Involvement of sphingosine kinase/sphingosine 1-phosphate metabolic pathway in spondyloarthritis. , 2017, Bone.

[8]  Y. Alippe,et al.  Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells , 2017, Scientific Reports.

[9]  C. Bougault,et al.  TNAP stimulates vascular smooth muscle cell trans-differentiation into chondrocytes through calcium deposition and BMP-2 activation: Possible implication in atherosclerotic plaque stability. , 2017, Biochimica et biophysica acta. Molecular basis of disease.

[10]  L. Nowak,et al.  Identification of altered brain metabolites associated with TNAP activity in a mouse model of hypophosphatasia using untargeted NMR‐based metabolomics analysis , 2017, Journal of neurochemistry.

[11]  T. Arnett,et al.  Pyrophosphate: a key inhibitor of mineralisation. , 2016, Current opinion in pharmacology.

[12]  H. Deng,et al.  Molecular genetics of the COL2A1-related disorders. , 2016, Mutation research. Reviews in mutation research.

[13]  N. Bishop Bone Material Properties in Osteogenesis Imperfecta , 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[14]  G. Dubyak,et al.  Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP , 2016, Nature Communications.

[15]  C. Fonta,et al.  Multiple Functions of MSCA-1/TNAP in Adult Mesenchymal Progenitor/Stromal Cells , 2015, Stem cells international.

[16]  J. Millán,et al.  Alkaline Phosphatase and Hypophosphatasia , 2015, Calcified Tissue International.

[17]  C. Müller,et al.  α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5'-Nucleotidase (CD73) Inhibitors. , 2015, Journal of medicinal chemistry.

[18]  J. Millán,et al.  Tissue-nonspecific alkaline phosphatase deficiency causes abnormal craniofacial bone development in the Alpl(-/-) mouse model of infantile hypophosphatasia. , 2014 .

[19]  O. Levy,et al.  Soluble Ecto-5′-nucleotidase (5′-NT), Alkaline Phosphatase, and Adenosine Deaminase (ADA1) Activities in Neonatal Blood Favor Elevated Extracellular Adenosine* , 2013, The Journal of Biological Chemistry.

[20]  R. Wightman,et al.  Tissue-Nonspecific Alkaline Phosphatase Acts Redundantly with PAP and NT5E to Generate Adenosine in the Dorsal Spinal Cord , 2013, The Journal of Neuroscience.

[21]  E. Vizi,et al.  CD39 and CD73 in immunity and inflammation. , 2013, Trends in molecular medicine.

[22]  I. Couillin,et al.  ATP release and purinergic signaling in NLRP3 inflammasome activation , 2013, Front. Immun..

[23]  B. Stec,et al.  Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[24]  J. Millán,et al.  Multisystemic functions of alkaline phosphatases. , 2013, Methods in molecular biology.

[25]  D. Magne,et al.  Isolation and characteristics of matrix vesicles. , 2013, Methods in molecular biology.

[26]  M. Wood,et al.  Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy. , 2012, Human molecular genetics.

[27]  M. Beer,et al.  Whole-body MRI in the childhood form of hypophosphatasia , 2011, Rheumatology International.

[28]  P. Kubes,et al.  Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation , 2010, Science.

[29]  S. Rankin,et al.  Neutrophil kinetics in health and disease , 2010, Trends in immunology.

[30]  M. Whyte Physiological role of alkaline phosphatase explored in hypophosphatasia , 2010, Annals of the New York Academy of Sciences.

[31]  A. Freemont,et al.  Chronic Recurrent Multifocal Osteomyelitis Mimicked in Childhood Hypophosphatasia , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[32]  D. Magne,et al.  TNF-alpha and IL-1beta inhibit RUNX2 and collagen expression but increase alkaline phosphatase activity and mineralization in human mesenchymal stem cells. , 2009, Life sciences.

[33]  P. Insel,et al.  Ecto-nucleoside Triphosphate Diphosphohydrolase 1 (E-NTPDase1/CD39) Regulates Neutrophil Chemotaxis by Hydrolyzing Released ATP to Adenosine* , 2008, Journal of Biological Chemistry.

[34]  A. Surprenant,et al.  Inhibition of Neutrophil Apoptosis by ATP Is Mediated by the P2Y11 Receptor1 , 2007, The Journal of Immunology.

[35]  J. Sévigny,et al.  Specificity of the ecto‐ATPase inhibitor ARL 67156 on human and mouse ectonucleotidases , 2007, British journal of pharmacology.

[36]  P. Ferguson,et al.  Autoinflammatory bone disorders , 2007, Current opinion in rheumatology.

[37]  M. Beer,et al.  Chronic multifocal non-bacterial osteomyelitis in hypophosphatasia mimicking malignancy , 2007, BMC pediatrics.

[38]  Linda Yip,et al.  ATP Release Guides Neutrophil Chemotaxis via P2Y2 and A3 Receptors , 2006, Science.

[39]  M. Beer,et al.  Effective NSAID treatment indicates that hyperprostaglandinism is affecting the clinical severity of childhood hypophosphatasia , 2006, Orphanet journal of rare diseases.

[40]  M. McKee,et al.  Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone. , 2005, Genes & development.

[41]  R. Terkeltaub,et al.  Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[42]  J. Millán,et al.  Alkaline Phosphatase Knock‐Out Mice Recapitulate the Metabolic and Skeletal Defects of Infantile Hypophosphatasia , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[43]  H. Seyberth,et al.  Treatment of childhood hypophosphatasia with nonsteroidal antiinflammatory drugs. , 1999, Bone.

[44]  J. Millán,et al.  Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia , 1997, Developmental dynamics : an official publication of the American Association of Anatomists.

[45]  R. Aebersold,et al.  Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase beta (HPTP beta) using synthetic phosphopeptides. , 1994, The Biochemical journal.

[46]  T. Barbui,et al.  Expression of leukocyte alkaline phosphatase gene in normal and leukemic cells: regulation of the transcript by granulocyte colony-stimulating factor. , 1990, Blood.

[47]  J. Hale,et al.  Isolation and characterization of calcium-accumulating matrix vesicles from chondrocytes of chicken epiphyseal growth plate cartilage in primary culture. , 1985, The Journal of biological chemistry.