Embedded Based Solution for Intracortical and Intracranial Microstimulations for Assessing the Behaviour of Rodents

Brain Stimulation has increased its popularity as it is an active and approved treatment for various neurological and psychiatric disorders. It is imperative to assess multiple states in animal models. For exploring the working model of Intracortical, Intracranial and Deep Brain Stimulations(DBS), behavioural animal models are crucial, and especially animal models are essential to probe into the underlying specific behaviours related to neurological disorders. This work depicts the evaluation of compact, lightweight remote communication based on Embedded Components for animal models in comparison with other models. Complete schematics of the design is described to ensure the reliability of this work. This device can be used as a hand tool to know the underlying theory of Brain Stimulation inside the behavioural animal model for neurological and psychiatric issues.

[1]  Hongwei Hao,et al.  Study on DBS device for small animals , 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[2]  Hong Jia,et al.  PRECLINICAL STUDY: Chronic deep brain stimulation in the rat nucleus accumbens and its effect on morphine reinforcement , 2008, Addiction biology.

[3]  Rajas P. Kale,et al.  Validation of a Portable Low-Power Deep Brain Stimulation Device Through Anxiolytic Effects in a Laboratory Rat Model , 2017, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[4]  Peter Seligman,et al.  Wireless induction coils embedded in diamond for power transfer in medical implants , 2017, Biomedical microdevices.

[5]  Abbas Z. Kouzani,et al.  A Head Mountable Deep Brain Stimulation Device for Laboratory Animals , 2011 .

[6]  K. Cheung Implantable microscale neural interfaces , 2007, Biomedical microdevices.

[7]  P. Salin,et al.  Portable microstimulator for chronic deep brain stimulation in freely moving rats , 2012, Journal of Neuroscience Methods.

[8]  Abbas Z. Kouzani,et al.  A Low Power Micro Deep Brain Stimulation Device for Murine Preclinical Research , 2013, IEEE Journal of Translational Engineering in Health and Medicine.

[9]  Jens Volkmann,et al.  Development of a head-mounted wireless microstimulator for deep brain stimulation in rats , 2017, Journal of Neuroscience Methods.

[10]  Houjun Wang,et al.  A radio-telemetry system for navigation and recording neuronal activity in free-roaming rats , 2012 .

[11]  Kartikeya Murari,et al.  A lightweight discrete biphasic current stimulator for rodent deep brain stimulation , 2015, 2015 IEEE Biomedical Circuits and Systems Conference (BioCAS).

[12]  Jan Gimsa,et al.  Optimizing a Rodent Model of Parkinson's Disease for Exploring the Effects and Mechanisms of Deep Brain Stimulation , 2011, Parkinson's disease.

[13]  Bernd Porr,et al.  SaBer DBS: A fully programmable, rechargeable, bilateral, charge-balanced preclinical microstimulator for long-term neural stimulation , 2013, Journal of Neuroscience Methods.

[14]  Liwei Lin,et al.  Energy harvesting from cerebrospinal fluid pressure fluctuations for self-powered neural implants , 2017, Biomedical microdevices.

[15]  H. Westenberg,et al.  Wireless implantable micro-stimulation device for high frequency bilateral deep brain stimulation in freely moving mice , 2012, Journal of Neuroscience Methods.