Isl1 promotes gene transcription through physical interaction with Set1/Mll complexes.

[1]  J. Davie,et al.  The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes , 2021, Clinical epigenetics.

[2]  Juan Wang,et al.  ISL1 promoted tumorigenesis and EMT via Aurora kinase A-induced activation of PI3K/AKT signaling pathway in neuroblastoma , 2021, Cell Death & Disease.

[3]  Y. Dou,et al.  Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin , 2021, Nature Communications.

[4]  G. Rutter,et al.  PDX1LOW MAFALOW β-cells contribute to islet function and insulin release , 2021, Nature Communications.

[5]  J. Trewhella,et al.  Contrasting DNA-binding behaviour by ISL1 and LHX3 underpins differential gene targeting in neuronal cell specification , 2020, Journal of structural biology: X.

[6]  Hao Jiang,et al.  A chromatin perspective on metabolic and genotoxic impacts on hematopoietic stem and progenitor cells , 2020, Cellular and Molecular Life Sciences.

[7]  Hao Jiang.  The complex activities of the SET1/MLL complex core subunits in development and disease. , 2020, Biochimica et biophysica acta. Gene regulatory mechanisms.

[8]  J. Robert,et al.  Isl1 Regulation of Nkx2.1 in the Early Foregut Epithelium Is Required for Trachea-Esophageal Separation and Lung Lobation. , 2019, Developmental cell.

[9]  Yong Chen,et al.  The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex , 2019, Nucleic acids research.

[10]  T. Milne,et al.  Why are so many MLL lysine methyltransferases required for normal mammalian development? , 2019, Cellular and Molecular Life Sciences.

[11]  C. Bakal,et al.  WDR5, BRCA1, and BARD1 Co-regulate the DNA Damage Response and Modulate the Mesenchymal-to-Epithelial Transition during Early Reprogramming , 2019, Stem cell reports.

[12]  Hao Jiang,et al.  Control of Hematopoietic Stem and Progenitor Cell Function through Epigenetic Regulation of Energy Metabolism and Genome Integrity , 2019, bioRxiv.

[13]  Yunfu Sun,et al.  Collaborative ISL1/GATA3 interaction in controlling neuroblastoma oncogenic pathways overlapping with but distinct from MYCN , 2019, Theranostics.

[14]  J. Ji,et al.  ISL1 predicts poor outcomes for patients with gastric cancer and drives tumor progression through binding to the ZEB1 promoter together with SETD7 , 2019, Cell Death & Disease.

[15]  Ashley R. Woodfin,et al.  Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3K4 Methylation. , 2018, Structure.

[16]  Ruo-Gu Li,et al.  ISL1 loss-of-function mutation contributes to congenital heart defects , 2018, Heart and Vessels.

[17]  Ashley R. Woodfin,et al.  Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy , 2018, Cell.

[18]  Jian Sun,et al.  ISL1 promotes cancer progression and inhibits cisplatin sensitivity in triple-negative breast cancer cells , 2018, International journal of molecular medicine.

[19]  Theodore Busby,et al.  Hijacking a key chromatin modulator creates epigenetic vulnerability for MYC-driven cancer , 2018, The Journal of clinical investigation.

[20]  Shihao Zhang,et al.  SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis. , 2018, Cancer cell.

[21]  Jia Gu,et al.  fastp: an ultra-fast all-in-one FASTQ preprocessor , 2018, bioRxiv.

[22]  Yunfu Sun,et al.  Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification , 2018, Cell Death & Disease.

[23]  J. Houseley,et al.  Tri-methylation of histone H3 lysine 4 facilitates gene expression in ageing cells , 2017, bioRxiv.

[24]  S. Buratowski,et al.  Determinants of Histone H3K4 Methylation Patterns. , 2017, Molecular cell.

[25]  A. Barski,et al.  Xist RNA repeat E is essential for ASH2L recruitment to the inactive X and regulates histone modifications and escape gene expression , 2017, PLoS genetics.

[26]  Jae W. Lee,et al.  The Isl1-Lhx3 Complex Promotes Motor Neuron Specification by Activating Transcriptional Pathways that Enhance Its Own Expression and Formation , 2017, eNeuro.

[27]  The UniProt Consortium.  UniProt: the universal protein knowledgebase , 2016, Nucleic Acids Res..

[28]  Hao Jiang,et al.  Dpy30 is critical for maintaining the identity and function of adult hematopoietic stem cells , 2016, The Journal of experimental medicine.

[29]  Yong Zhang,et al.  H3K4 Methyltransferase Set1a Is A Key Oct4 Coactivator Essential for Generation of Oct4 Positive Inner Cell Mass , 2016, Stem cells.

[30]  Shuai Li,et al.  Structural basis for activity regulation of MLL family methyltransferases , 2016, Nature.

[31]  Hao Jiang,et al.  Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors , 2015, PloS one.

[32]  Qing-Yu He,et al.  ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization , 2015, Bioinform..

[33]  E. Olejniczak,et al.  Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC. , 2015, Molecular cell.

[34]  J. Thornton,et al.  Molecular basis for DPY-30 association to COMPASS-like and NURF complexes. , 2014, Structure.

[35]  J. Schug,et al.  Islet-1 Is Essential for Pancreatic β-Cell Function , 2014, Diabetes.

[36]  Chenbei Chang,et al.  The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells. , 2014, Blood.

[37]  Marco Y. Hein,et al.  Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ * , 2014, Molecular & Cellular Proteomics.

[38]  X. Mu,et al.  Isl1 and Pou4f2 Form a Complex to Regulate Target Genes in Developing Retinal Ganglion Cells , 2014, PloS one.

[39]  Howard Y. Chang,et al.  Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency , 2014, eLife.

[40]  Jingxuan Liu,et al.  Elevation of transcription factor Islet-1 levels in vivo increases β-cell function but not β-cell mass , 2012, Islets.

[41]  F. Cao,et al.  Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30 , 2012, Cell Research.

[42]  Ping Chen,et al.  ISL1 Promotes Pancreatic Islet Cell Proliferation , 2011, PloS one.

[43]  Jonathan M. Monk,et al.  Wdr5 Mediates Self-Renewal and Reprogramming via the Embryonic Stem Cell Core Transcriptional Network , 2011, Cell.

[44]  B. Bernstein,et al.  Role for Dpy-30 in ES Cell-Fate Specification by Regulation of H3K4 Methylation within Bivalent Domains , 2011, Cell.

[45]  A. Shilatifard.  Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation. , 2008, Current opinion in cell biology.

[46]  K. Laugwitz,et al.  Cardiovascular development: towards biomedical applicability , 2007, Cellular and Molecular Life Sciences.

[47]  F. Hallböök,et al.  Early identification of retinal subtypes in the developing, pre-laminated chick retina using the transcription factors Prox1, Lim1, Ap2alpha, Pax6, Isl1, Isl2, Lim3 and Chx10. , 2006, European journal of histochemistry : EJH.

[48]  Ping Chen,et al.  ISL1 physically interacts with BETA2 to promote insulin gene transcriptional synergy in non-beta cells. , 2005, Biochimica et biophysica acta.

[49]  Yunqing Shi,et al.  Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. , 2003, Developmental cell.

[50]  T. Jessell,et al.  Requirement for LIM Homeobox Gene Isl1 in Motor Neuron Generation Reveals a Motor Neuron– Dependent Step in Interneuron Differentiation , 1996, Cell.

[51]  Stefan Thor,et al.  Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo-and a Cys–His domain , 1990, Nature.

[52]  which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets , 2011 .