A smart pill for drug delivery with sensing capabilities

In this paper a novel system for local drug delivery is described. The actuation principle of the micropump used for drug delivery relies on the electrolysis of a water-based solution, which is separated from a drug reservoir by an elastic membrane. The electrolytically produced gases pressurize the electrolytic solution reservoir, causing the deflection of the elastic membrane. Such deflection, in turn, forces the drug out of its reservoir through a nozzle. The proposed system is integrated in a swallowable capsule, equipped with an impedance sensor useful to acquire information on the physiological conditions of the tissue. Such information can be used to control pump activation.

[1]  Jose L. Gonzalez-Guillaumin,et al.  Ingestible Capsule for Impedance and pH Monitoring in the Esophagus , 2007, IEEE Transactions on Biomedical Engineering.

[2]  A. Bredenoord,et al.  Esophageal Acid Exposure Decreases Intraluminal Baseline Impedance Levels , 2011, The American Journal of Gastroenterology.

[3]  A. Staiano,et al.  Esophageal impedance baseline according to different time intervals , 2012, European Journal of Medical Research.

[4]  A MINIATURIZED DRUG-DELIVERY SYSTEM FOR INTRA-CORPOREAL USE , 2004 .

[5]  Viera Stopjakova,et al.  WIRELESS MEASUREMENT SYSTEM FOR NON-INVASIVE BIOMEDICAL MONITORING OF PSYCHO-PHYSIOLOGICAL PROCESSES , 2009 .

[6]  P. Bogonez-Franco,et al.  Implantable bioimpedance monitor using ZigBee , 2009, 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[7]  K. Cheng,et al.  Electrical Impedance Spectroscopy as Electrical Biopsy for Monitoring Radiation Sequelae of Intestine in Rats , 2013, BioMed research international.

[8]  Thomas de Quincey.  [C] , 2000, The Works of Thomas De Quincey, Vol. 1: Writings, 1799–1820.

[9]  J. Portilla,et al.  Low-power, self-contained, reciprocating micropump through electrolysis and catalyst-driven recombination toward drug delivery applications , 2013, 2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS).

[10]  S. B. Tiwari,et al.  Extended-release oral drug delivery technologies: monolithic matrix systems. , 2008, Methods in molecular biology.

[11]  Colin G Cameron,et al.  Electrolytic actuators: Alternative, high-performance, material-based devices , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[12]  P. Rutgeerts,et al.  Infliximab, azathioprine, or combination therapy for Crohn's disease. , 2010, The New England journal of medicine.