An easily integrative and efficient micromixer and its application to the spectroscopic detection of glucose-catalyst reactions.

The focus of this paper is on the fabrication of a PDMS-based passive efficient micromixer to be easily integrated into the other on-chip microfluidic system. The mixing is achieved by "strong stretching and folding," which employs a three-dimensional microchannel structure. By the simultaneously vertical and transversal dispersion of fluids, strong advection is developed. Owing to this powerful mixing performance (more than 70% of the mixing is accomplished within 2.3 mm over a wide range of Reynold number (Re)), the smaller integrative mixer can be realized. The feasibility and the potential usefulness of an integrative micromixer were evaluated by incorporating two mixers into the microchannel for the spectroscopic detection of a glucose-catalyst reaction. The results demonstrate a promising performance for diverse applications in the assay or synthesis of biological or chemical materials.

[1]  I. Mezić,et al.  Chaotic Mixer for Microchannels , 2002, Science.

[2]  E. Delamarche,et al.  Patterned delivery of immunoglobulins to surfaces using microfluidic networks. , 1997, Science.

[3]  Richard M Crooks,et al.  Hydrogel-based microreactors as a functional component of microfluidic systems. , 2002, Analytical chemistry.

[4]  Kee Suk Ryu,et al.  A magnetic microstirrer and array for microfluidic mixing , 2002 .

[5]  Jin-Woo Choi,et al.  A novel in-plane passive microfluidic mixer with modified Tesla structures. , 2004, Lab on a chip.

[6]  G M Whitesides,et al.  Fabrication inside microchannels using fluid flow. , 2000, Accounts of chemical research.

[7]  Robin H. Liu,et al.  An organic self-regulating microfluidic system. , 2001, Lab on a chip.

[8]  Göran Stemme,et al.  A fast passive and planar liquid sample micromixer. , 2004, Lab on a chip.

[9]  D. Beebe,et al.  Three-dimensional micro-channel fabrication in polydimethylsiloxane (PDMS) elastomer , 2000, Journal of Microelectromechanical Systems.

[10]  G M Whitesides,et al.  Pressure-driven laminar flow in tangential microchannels: an elastomeric microfluidic switch. , 2001, Analytical chemistry.

[11]  Robin H. Liu,et al.  Passive mixing in a three-dimensional serpentine microchannel , 2000, Journal of Microelectromechanical Systems.

[12]  Adam Heller,et al.  Elimination of electrooxidizable interferants in glucose electrodes , 1991 .

[13]  Vincent Studer,et al.  A nanoliter-scale nucleic acid processor with parallel architecture , 2004, Nature Biotechnology.

[14]  K. Jensen.  Microreaction engineering * is small better? , 2001 .

[15]  Robin H. Liu,et al.  Bubble-induced acoustic micromixing. , 2002, Lab on a chip.

[16]  Richard M Crooks,et al.  Efficient mixing and reactions within microfluidic channels using microbead-supported catalysts. , 2002, Journal of the American Chemical Society.

[17]  J. Voldman,et al.  An integrated liquid mixer/valve , 2000, Journal of Microelectromechanical Systems.

[18]  B. Finlayson,et al.  Combinatorial mixing of microfluidic streams. , 2004, Lab on a chip.

[19]  T. Johnson,et al.  Rapid microfluidic mixing. , 2002, Analytical chemistry.

[20]  B. Finlayson,et al.  Quantitative analysis of molecular interaction in a microfluidic channel: the T-sensor. , 1999, Analytical chemistry.