Protein tyrosine phosphatases ε and α perform nonredundant roles in osteoclasts

The closely related tyrosine phosphatases PTPa and PTPe fulfill distinct roles in osteoclasts. The various effects of each PTP on podosome organization in osteoclasts are caused by their distinct N-termini. The function of PTPe in these cells requires the presence of its 12 N-terminal residues, in particular serine 2.

[1]  M. Shivanna,et al.  Dynamin and PTP-PEST cooperatively regulate Pyk2 dephosphorylation in osteoclasts. , 2012, The international journal of biochemistry & cell biology.

[2]  Alon Chen,et al.  Protein tyrosine phosphatase epsilon affects body weight by downregulating leptin signaling in a phosphorylation-dependent manner. , 2011, Cell metabolism.

[3]  Y. Mishina,et al.  Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations , 2011, Disease Models & Mechanisms.

[4]  F. Li,et al.  MAP Kinase Phosphatase-1 Protects against Inflammatory Bone Loss , 2009, Journal of dental research.

[5]  A. Elson,et al.  Protein tyrosine phosphatase epsilon regulates integrin-mediated podosome stability in osteoclasts by activating Src. , 2009, Molecular biology of the cell.

[6]  A. Bennett,et al.  Role of MKP-1 in osteoclasts and bone homeostasis. , 2009, The American journal of pathology.

[7]  Kenji F. Tanaka,et al.  A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure , 2009, Cell.

[8]  M. Schaller,et al.  Activation of Src kinase by protein–tyrosine phosphatase–PEST in osteoclasts: Comparative analysis of the effects of bisphosphonate and protein–tyrosine phosphatase inhibitor on Src activation in vitro , 2009, Journal of cellular physiology.

[9]  K. Lau,et al.  Targeted Transgenic Expression of an Osteoclastic Transmembrane Protein-tyrosine Phosphatase in Cells of Osteoclastic Lineage Increases Bone Resorption and Bone Loss in Male Young Adult Mice* , 2009, Journal of Biological Chemistry.

[10]  P. Goichberg,et al.  CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules , 2008, The Journal of experimental medicine.

[11]  A. Elson,et al.  Neu-mediated phosphorylation of protein tyrosine phosphatase epsilon is critical for activation of Src in mammary tumor cells , 2007, Oncogene.

[12]  P. De Camilli,et al.  Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2−/− mice , 2007, The Journal of cell biology.

[13]  A. Elson,et al.  Association of Tyrosine Phosphatase Epsilon with Microtubules Inhibits Phosphatase Activity and Is Regulated by the Epidermal Growth Factor Receptor , 2007, Molecular and Cellular Biology.

[14]  K. Lau,et al.  A transmembrane osteoclastic protein-tyrosine phosphatase regulates osteoclast activity in part by promoting osteoclast survival through c-Src-dependent activation of NFkappaB and JNK2. , 2007, Archives of biochemistry and biophysics.

[15]  K. Lau,et al.  Targeted deletion of the osteoclast protein‐tyrosine phosphatase (PTP‐oc) promoter prevents RANKL‐mediated osteoclastic differentiation of RAW264.7 cells , 2007, FEBS letters.

[16]  L. Lasky,et al.  Phosphorylation of a Wiscott-Aldrich Syndrome Protein-associated Signal Complex Is Critical in Osteoclast Bone Resorption* , 2007, Journal of Biological Chemistry.

[17]  S. Teitelbaum.  Osteoclasts: what do they do and how do they do it? , 2007, The American journal of pathology.

[18]  Roland Baron,et al.  Molecular regulation of osteoclast activity , 2007, Reviews in Endocrine and Metabolic Disorders.

[19]  L. Addadi,et al.  Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclasts , 2006, Journal of Cell Science.

[20]  Ari Elson,et al.  Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells , 2006, Nature Medicine.

[21]  C. Pallen,et al.  Integrin-induced Tyrosine Phosphorylation of Protein-tyrosine Phosphatase-α Is Required for Cytoskeletal Reorganization and Cell Migration* , 2006, Journal of Biological Chemistry.

[22]  L. Addadi,et al.  The molecular dynamics of osteoclast adhesions. , 2006, European journal of cell biology.

[23]  F. Ross.  M‐CSF, c‐Fms, and Signaling in Osteoclasts and their Precursors , 2006, Annals of the New York Academy of Sciences.

[24]  Sakae Tanaka,et al.  The role of c-Src kinase in the regulation of osteoclast function , 2006, Modern rheumatology.

[25]  Masaki Noda,et al.  Leptin regulation of bone resorption by the sympathetic nervous system and CART , 2005, Nature.

[26]  M. Schachner,et al.  RPTPα is essential for NCAM-mediated p59fyn activation and neurite elongation , 2005, The Journal of cell biology.

[27]  Archana Sanjay,et al.  Src Kinase Activity Is Essential for Osteoclast Function* , 2004, Journal of Biological Chemistry.

[28]  J. Brugge,et al.  Src kinase activation by direct interaction with the integrin β cytoplasmic domain , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[29]  R. Chiusaroli,et al.  Tyrosine phosphatase epsilon is a positive regulator of osteoclast function in vitro and in vivo. , 2003, Molecular biology of the cell.

[30]  David L. Lacey,et al.  Osteoclast differentiation and activation , 2003, Nature.

[31]  A. Elson,et al.  Tyrosine Phosphatase-ε Activates Src and Supports the Transformed Phenotype of Neu-induced Mammary Tumor Cells* , 2003, The Journal of Biological Chemistry.

[32]  F. Saltel,et al.  Podosomes display actin turnover and dynamic self-organization in osteoclasts expressing actin-green fluorescent protein. , 2003, Molecular biology of the cell.

[33]  X. Si,et al.  PTPα regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration , 2003, The Journal of cell biology.

[34]  A. Elson,et al.  Nuclear Localization of Non-receptor Protein Tyrosine Phosphatase ϵ Is Regulated by Its Unique N-Terminal Domain , 2002 .

[35]  Patricia Ducy,et al.  Leptin Regulates Bone Formation via the Sympathetic Nervous System , 2002, Cell.

[36]  A. Elson,et al.  Regulation of Protein-tyrosine Phosphatases α and ε by Calpain-mediated Proteolytic Cleavage* , 2001, The Journal of Biological Chemistry.

[37]  J. Clausen,et al.  Comparative study of protein tyrosine phosphatase-epsilon isoforms: membrane localization confers specificity in cellular signalling. , 2001, The Biochemical journal.

[38]  A. Elson,et al.  Generation of novel cytoplasmic forms of protein tyrosine phosphatase epsilon by proteolytic processing and translational control , 2000, Oncogene.

[39]  B. Attali,et al.  Hypomyelination and increased activity of voltage‐gated K+ channels in mice lacking protein tyrosine phosphatase ϵ , 2000, The EMBO journal.

[40]  T. Hunter,et al.  Receptor-Like Protein Tyrosine Phosphatase α Homodimerizes on the Cell Surface , 2000, Molecular and Cellular Biology.

[41]  D. Shalloway,et al.  A phosphotyrosine displacement mechanism for activation of Src by PTPα , 2000, The EMBO journal.

[42]  J. Noel,et al.  Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-α , 1999, Nature.

[43]  R. Baron,et al.  The tyrosine phosphatase SHP-1 is a negative regulator of osteoclastogenesis and osteoclast resorbing activity: increased resorption and osteopenia in me(v)/me(v) mutant mice. , 1999, Bone.

[44]  K. Takagi,et al.  Deficiency of SHP-1 protein-tyrosine phosphatase activity results in heightened osteoclast function and decreased bone density. , 1999, The American journal of pathology.

[45]  K. Lim,et al.  Targeted disruption of the tyrosine phosphatase PTPα leads to constitutive downregulation of the kinases Src and Fyn , 1999, Current Biology.

[46]  J. Sap,et al.  Receptor protein tyrosine phosphatase α activates Src-family kinases and controls integrin-mediated responses in fibroblasts , 1999, Current Biology.

[47]  K. Kikuchi,et al.  Molecular cloning of a novel cytoplasmic protein tyrosine phosphatase PTPε , 1996 .

[48]  P. Leder,et al.  Identification of a cytoplasmic, phorbol ester-inducible isoform of protein tyrosine phosphatase epsilon. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[49]  A. Elson,et al.  Protein-tyrosine Phosphatase ϵ , 1995, The Journal of Biological Chemistry.

[50]  M. Peppelenbosch,et al.  Receptor protein tyrosine phosphatase alpha activates pp60c‐src and is involved in neuronal differentiation. , 1993, The EMBO journal.

[51]  Xinyang Zheng,et al.  Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase , 1992, Nature.

[52]  Allan Bradley,et al.  Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice , 1991, Cell.

[53]  Haruo,et al.  Structural diversity and evolution of human receptor‐like protein tyrosine phosphatases. , 1990, The EMBO journal.

[54]  P. De Camilli,et al.  The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclasts. , 2008, Molecular biology of the cell.

[55]  Teiji Wada,et al.  RANKL-RANK signaling in osteoclastogenesis and bone disease. , 2006, Trends in molecular medicine.

[56]  A. Elson,et al.  Tyrosine phosphatase-epsilon activates Src and supports the transformed phenotype of Neu-induced mammary tumor cells. , 2003, The Journal of biological chemistry.

[57]  A. Elson,et al.  Nuclear localization of non-receptor protein tyrosine phosphatase epsilon is regulated by its unique N-terminal domain. , 2002, Experimental cell research.

[58]  A. Elson,et al.  Regulation of protein-tyrosine phosphatases alpha and epsilon by calpain-mediated proteolytic cleavage. , 2001, The Journal of biological chemistry.

[59]  N. Tanuma,et al.  Distinct promoters control transmembrane and cytosolic protein tyrosine phosphatase epsilon expression during macrophage differentiation. , 1999, European journal of biochemistry.

[60]  K. Kikuchi,et al.  Molecular cloning of a novel cytoplasmic protein tyrosine phosphatase PTP epsilon. , 1996, Biochemical and biophysical research communications.