Direct cadiac electorphysiologic effects of sufentanil and vecuronium in isolated guinea‐pig hearts

Sufentanil and vecuronium are commonly used simultaneously in anaesthesia. Bradycardia and asystole have been described immediately after the administration of these two compounds. Therefore, the purpose of the present study was to evaluate the direct cardiac effects of sufentanil and vecuronium in all parts of the cardiac pacemaker and conduction system.

[1]  J. Castillo-olivares,et al.  Electrophysiological effects of atracurium and vecuronium on normal and denervated hearts. , 1992, Journal of cardiothoracic and vascular anesthesia.

[2]  K. Anand,et al.  Halothane-morphine compared with high-dose sufentanil for anesthesia and postoperative analgesia in neonatal cardiac surgery. , 1992, The New England journal of medicine.

[3]  W. Schmeling,et al.  Persistent bradycardia with episodic sinus arrest after sufentanil and vecuronium administration--successful treatment with isoproterenol. , 1990, Journal of cardiothoracic anesthesia.

[4]  H. Tritthart,et al.  Assessment of the conduction of the cardiac impulse by a new epicardiac surface and stimulation technique (SST-ECG) in Langendorff perfused mammalian hearts. , 1989, Journal of pharmacological methods.

[5]  L. Teba,et al.  Sinus node exit block following administration of vecuronium. , 1988, Anesthesiology.

[6]  N. Starr,et al.  Bradycardia and asystole following the rapid administration of sufentanil with vecuronium. , 1986, Anesthesiology.

[7]  J. Loeb,et al.  Parasympathomimetic effects of fentanyl on the canine sinus node. , 1984, Journal of the autonomic nervous system.

[8]  P. Hickey,et al.  Fentanyl‐and Sufentanil‐Oxygen‐Pancuronium Anesthesia for Cardiac Surgery in Infants , 1984, Anesthesia and analgesia.

[9]  J. Brodsky,et al.  Postoperative muscle pains and suxamethonium. , 1980, British journal of anaesthesia.

[10]  Ronald D. Miller,et al.  Comparison of the Cardiovascular Actions of Org NC 45 with Those Produced By Other Non-Depolarizing Neuromuscular Blocking Agents in Experimental Animals , 1980 .

[11]  M. Laubie,et al.  Centrally mediated bradycardia and hypotension induced by narcotic analgesics: dextromoramide and fentanyl. , 1974, European journal of pharmacology.

[12]  W. Daggett,et al.  Cardiovascular response to large doses of intravenous morphine in man. , 1969, The New England journal of medicine.