Exposure Models for REACH and Occupational Safety and Health Regulations

Model tools for estimating hazardous substance exposure are an accepted part of regulatory risk assessments in Europe, and models underpin control banding tools used to help manage chemicals in workplaces. Of necessity the models are simplified abstractions of real-life working situations that aim to capture the essence of the scenario to give estimates of actual exposures with an appropriate margin of safety. The basis for existing inhalation exposure assessment tools has recently been discussed by some scientists who have argued for the use of more complex models. In our opinion, the currently accepted tools are documented to be the most robust way for workplace health and safety practitioners and others to estimate inhalation exposure. However, we recognise that it is important to continue the scientific development of exposure modelling to further elaborate and improve the existing methodologies.

[1]  Erik Tielemans,et al.  'Stoffenmanager', a web-based control banding tool using an exposure process model. , 2008, The Annals of occupational hygiene.

[2]  C. Keil,et al.  Interzonal airflow rates for use in near-field far-field workplace concentration modeling , 2017, Journal of occupational and environmental hygiene.

[3]  John Kingston,et al.  The development of the EASE model. , 2005, The Annals of occupational hygiene.

[4]  P G Evans,et al.  Risk management measures for chemicals: the “COSHH essentials” approach , 2007, Journal of Exposure Science and Environmental Epidemiology.

[5]  David M Zalk,et al.  History and Evolution of Control Banding: A Review , 2006, Journal of occupational and environmental hygiene.

[6]  Charles E Feigley,et al.  The Effect of Worker's Location, Orientation, and Activity on Exposure , 2007, Journal of occupational and environmental hygiene.

[7]  Csp Benjamin Craig Economical Large-Scale Indoor Release Modeling Using the AIHA Mathematical Models for Estimating Occupational Exposure to Chemicals , 2019 .

[8]  Hans Kromhout,et al.  Conceptual model for assessment of inhalation exposure: defining modifying factors. , 2008, The Annals of occupational hygiene.

[9]  John W Cherrie,et al.  Comparison of measured dermal dust exposures with predicted exposures given by the EASE expert system. , 2005, The Annals of occupational hygiene.

[10]  Asger W. Nørgaard,et al.  Quantitative material releases from products and articles containing manufactured nanomaterials: Towards a release library , 2017 .

[11]  Wouter Fransman,et al.  Stoffenmanager exposure model: development of a quantitative algorithm. , 2008, The Annals of occupational hygiene.

[12]  Hans Kromhout,et al.  Advanced Reach Tool (ART): development of the mechanistic model. , 2011, The Annals of occupational hygiene.

[13]  Eliseo Monfort,et al.  Testing the performance of one and two box models as tools for risk assessment of particle exposure during packing of inorganic fertilizer. , 2019, The Science of the total environment.

[14]  J. Cherrie The effect of room size and general ventilation on the relationship between near and far-field concentrations. , 1999, Applied occupational and environmental hygiene.

[15]  Hans Kromhout,et al.  Advanced REACH Tool (ART): calibration of the mechanistic model. , 2011, Journal of environmental monitoring : JEM.

[16]  Carlos Rodriguez,et al.  The ECETOC approach to targeted risk assessment; lessons and experiences relevant to REACH , 2007, Journal of Exposure Science and Environmental Epidemiology.

[17]  Wouter Fransman,et al.  Revisiting the effect of room size and general ventilation on the relationship between near- and far-field air concentrations. , 2011, The Annals of occupational hygiene.

[18]  John W Cherrie,et al.  The validity of the EASE expert system for inhalation exposures. , 2005, The Annals of occupational hygiene.

[19]  Wouter Fransman,et al.  Conceptual model for assessment of inhalation exposure to manufactured nanoparticles , 2011, Journal of Exposure Science and Environmental Epidemiology.

[20]  R. Vincent,et al.  Assessment of occupational exposure to chemicals by air sampling for comparison with limit values: the influence of sampling strategy. , 2014, The Annals of occupational hygiene.

[21]  John W Cherrie,et al.  Validation of Lower Tier Exposure Tools Used for REACH: Comparison of Tools Estimates With Available Exposure Measurements , 2017, Annals of work exposures and health.

[22]  Minnamari Vippola,et al.  Influence of relative humidity and physical load during storage on dustiness of inorganic nanomaterials: implications for testing and risk assessment , 2015, Journal of Nanoparticle Research.

[23]  Domenico Maria Cavallo,et al.  How to Obtain a Reliable Estimate of Occupational Exposure? Review and Discussion of Models’ Reliability , 2019, International journal of environmental research and public health.

[24]  W. Fransman,et al.  Indoor dispersion of airborne nano and fine particles: main factors affecting spatial and temporal distribution in the frame of exposure modelling. , 2019, Indoor air.

[25]  M. Viana,et al.  Modeling of High Nanoparticle Exposure in an Indoor Industrial Scenario with a One-Box Model , 2019, International journal of environmental research and public health.

[26]  Miikka Dal Maso,et al.  Comparison of Geometrical Layouts for a Multi-Box Aerosol Model from a Single-Chamber Dispersion Study , 2018 .

[27]  David M Zalk,et al.  Banding the World Together; The Global Growth of Control Banding and Qualitative Occupational Risk Management , 2011, Safety and health at work.

[28]  Miikka Dal Maso,et al.  Source specific exposure and risk assessment for indoor aerosols. , 2019, The Science of the total environment.

[29]  Antti J Koivisto,et al.  The general ventilation multipliers calculated by using a standard Near-Field/Far-Field model , 2018, Journal of occupational and environmental hygiene.

[30]  Steffen Foss Hansen,et al.  Control banding tools for occupational exposure assessment of nanomaterials — Ready for use in a regulatory context? , 2016 .

[31]  Koen Verbist,et al.  An Intervention Study on the Implementation of Control Banding in Controlling Exposure to Hazardous Chemicals in Small and Medium-sized Enterprises , 2015, Safety and health at work.