Cardiac output distribution measured with radioactive microspheres in the mouse.

Summary A radioactive microsphere method for the determination of cardiac output distribution has been adapted to the mouse. Microspheres injected into the left ventricle are distributed to the tissues proportionally to theirs blood flow and trapped by the microvasculature during the first passage. The assumptions for the application of this method were checked. Two determinations of cardiac output distribution can be made in the same animal and the effect of noradrenaline was evaluated.

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