Discovery of novel HSP90 inhibitors that induced apoptosis and impaired autophagic flux in A549 lung cancer cells.

[1]  D. Gewirth Paralog Specific Hsp90 Inhibitors - A Brief History and a Bright Future. , 2016, Current topics in medicinal chemistry.

[2]  B. Blagg,et al.  Diverging Novobiocin Anti-Cancer Activity from Neuroprotective Activity through Modification of the Amide Tail. , 2016, ACS medicinal chemistry letters.

[3]  P. Workman,et al.  Maximizing the Therapeutic Potential of HSP90 Inhibitors , 2015, Molecular Cancer Research.

[4]  P. Panda,et al.  Mechanism of autophagic regulation in carcinogenesis and cancer therapeutics. , 2015, Seminars in cell & developmental biology.

[5]  P. Sorensen,et al.  Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival , 2014, Nature Communications.

[6]  M. Li,et al.  Biological activities of novel pyrazolyl hydroxamic acid derivatives against human lung cancer cell line A549. , 2014, European journal of medicinal chemistry.

[7]  J. Renoir,et al.  Synthesis and antiproliferative activity of novobiocin analogues as potential hsp90 inhibitors. , 2014, European journal of medicinal chemistry.

[8]  Jun-Ying Miao,et al.  Discovery of a novel fluorescent HSP90 inhibitor and its anti-lung cancer effect , 2014 .

[9]  R. Vento,et al.  WIN induces apoptotic cell death in human colon cancer cells through a block of autophagic flux dependent on PPARγ down-regulation , 2014, Apoptosis.

[10]  S. Ramalingam,et al.  Heat shock protein 90 inhibitors in non-small-cell lung cancer , 2014, Current opinion in oncology.

[11]  G. Kibria,et al.  Cancer multidrug resistance: mechanisms involved and strategies for circumvention using a drug delivery system , 2013, Archives of Pharmacal Research.

[12]  F. Kiessling,et al.  Multidrug resistance: Physiological principles and nanomedical solutions. , 2013, Advanced drug delivery reviews.

[13]  J. Mak,et al.  Combination of arsenic trioxide and chemotherapy in small cell lung cancer. , 2013, Lung cancer.

[14]  H. Saibil,et al.  ATP-Driven Molecular Chaperone Machines , 2013, Biopolymers.

[15]  Agostino Casapullo,et al.  Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor. , 2013, Chemical communications.

[16]  Seamus J. Martin,et al.  Measuring apoptosis by microscopy and flow cytometry. , 2013, Methods.

[17]  R. Kurzrock,et al.  Targeting the molecular chaperone heat shock protein 90 (HSP90): lessons learned and future directions. , 2013, Cancer treatment reviews.

[18]  F. Buss,et al.  Autophagy-receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome , 2012, Nature Cell Biology.

[19]  Paul Workman,et al.  Hsp90 Molecular Chaperone Inhibitors: Are We There Yet? , 2012, Clinical Cancer Research.

[20]  K. Dalby,et al.  Targeting the pro-death and pro-survival functions of autophagy as novel therapeutic strategies in cancer , 2010, Autophagy.

[21]  K. Ballman,et al.  P-Glycoprotein-mediated resistance to Hsp90-directed therapy is eclipsed by the heat shock response. , 2008, Cancer research.

[22]  J. Renoir,et al.  Synthesis and biological activity of simplified denoviose-coumarins related to novobiocin as potent inhibitors of heat-shock protein 90 (hsp90). , 2008, Bioorganic & medicinal chemistry letters.

[23]  B. Stella,et al.  New novobiocin analogues as antiproliferative agents in breast cancer cells and potential inhibitors of heat shock protein 90. , 2007, Journal of medicinal chemistry.

[24]  G. Bjørkøy,et al.  p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy* , 2007, Journal of Biological Chemistry.

[25]  B. Levine,et al.  Cell biology: Autophagy and cancer , 2007, Nature.

[26]  Anthony Maxwell,et al.  Novobiocin: redesigning a DNA gyrase inhibitor for selective inhibition of hsp90. , 2006, Journal of the American Chemical Society.

[27]  Y. Kondo,et al.  Autophagy and Cancer Therapy , 2006, Autophagy.

[28]  Xiao Ming Yu,et al.  Hsp90 inhibitors identified from a library of novobiocin analogues. , 2005, Journal of the American Chemical Society.

[29]  F. Hofmann,et al.  The Insulin-Like Growth Factor-I Receptor Kinase Inhibitor, NVP-ADW742, Sensitizes Small Cell Lung Cancer Cell Lines to the Effects of Chemotherapy , 2005, Clinical Cancer Research.

[30]  Scott W. Lowe,et al.  Apoptosis A Link between Cancer Genetics and Chemotherapy , 2002, Cell.

[31]  L. Neckers,et al.  Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins. , 2000, Journal of the National Cancer Institute.

[32]  E. Jaffe,et al.  Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. , 1973, The Journal of clinical investigation.