Adenosine deaminase ADAR1 increases gene expression at the translational level by decreasing protein kinase PKR-dependent eIF-2alpha phosphorylation.
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[1] Zhijian J. Chen,et al. RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway , 2009, Cell.
[2] C. Samuel,et al. The RNA-activated Protein Kinase Enhances the Induction of Interferon-β and Apoptosis Mediated by Cytoplasmic RNA Sensors* , 2009, Journal of Biological Chemistry.
[3] Gene W. Yeo,et al. Divergent Transcription from Active Promoters , 2008, Science.
[4] K. Kinzler,et al. The Antisense Transcriptomes of Human Cells , 2008, Science.
[5] S. Maas,et al. Characterization of ADAR1-mediated modulation of gene expression. , 2008, Biochemical and biophysical research communications.
[6] G. Barber,et al. STING an Endoplasmic Reticulum Adaptor that Facilitates Innate Immune Signaling , 2008, Nature.
[7] Hideo Negishi,et al. Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules , 2008, Proceedings of the National Academy of Sciences.
[8] C. Coban,et al. TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines , 2008, Nature.
[9] H. Rammensee,et al. Plasmid DNA- and messenger RNA-based anti-cancer vaccination. , 2008, Immunology letters.
[10] C. Samuel,et al. Loss of Protein Kinase PKR Expression in Human HeLa Cells Complements the Vaccinia Virus E3L Deletion Mutant Phenotype by Restoration of Viral Protein Synthesis , 2007, Journal of Virology.
[11] J. Casey,et al. RNA Editing of the Human Herpesvirus 8 Kaposin Transcript Eliminates Its Transforming Activity and Is Induced during Lytic Replication , 2007, Journal of Virology.
[12] S. Akira,et al. Toll-like Receptors and Type I Interferons* , 2007, Journal of Biological Chemistry.
[13] C. Samuel,et al. Protein Kinase PKR Plays a Stimulus- and Virus-Dependent Role in Apoptotic Death and Virus Multiplication in Human Cells , 2007, Journal of Virology.
[14] J. Puglisi,et al. Molecular Framework for the Activation of RNA-dependent Protein Kinase*♦ , 2007, Journal of Biological Chemistry.
[15] Jane-Jane Chen. Regulation of protein synthesis by the heme-regulated eIF2alpha kinase: relevance to anemias. , 2007, Blood.
[16] Nathan F. Bouxsein,et al. Structure and gene silencing activities of monovalent and pentavalent cationic lipid vectors complexed with siRNA. , 2007, Biochemistry.
[17] S. Akira,et al. Viral Infections Activate Types I and III Interferon Genes through a Common Mechanism* , 2007, Journal of Biological Chemistry.
[18] E. Domingo,et al. Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action , 2006, Microbiology and Molecular Biology Reviews.
[19] D. von Laer,et al. A-to-G Hypermutation in the Genome of Lymphocytic Choriomeningitis Virus , 2006, Journal of Virology.
[20] G. Scheper,et al. Defective translation initiation causes vanishing of cerebral white matter. , 2006, Trends in molecular medicine.
[21] Arvin C. Dar,et al. Mechanistic Link between PKR Dimerization, Autophosphorylation, and eIF2α Substrate Recognition , 2005, Cell.
[22] A. Rich,et al. The crystal structure of the Zbeta domain of the RNA-editing enzyme ADAR1 reveals distinct conserved surfaces among Z-domains. , 2005, Journal of molecular biology.
[23] P. Kao,et al. ADAR1 Interacts with NF90 through Double-Stranded RNA and Regulates NF90-Mediated Gene Expression Independently of RNA Editing , 2005, Molecular and Cellular Biology.
[24] M. Puig,et al. New Antiviral Pathway That Mediates Hepatitis C Virus Replicon Interferon Sensitivity through ADAR1 , 2005, Journal of Virology.
[25] C. Samuel,et al. Expression of Interferon-inducible RNA Adenosine Deaminase ADAR1 during Pathogen Infection and Mouse Embryo Development Involves Tissue-selective Promoter Utilization and Alternative Splicing* , 2005, Journal of Biological Chemistry.
[26] G. Sen,et al. PACT-mediated enhancement of reporter gene expression at the translational level. , 2003, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.
[27] Charles E Samuel,et al. RNA Editing Minireview Series* , 2003, The Journal of Biological Chemistry.
[28] J. Casey,et al. Inhibition of Hepatitis Delta Virus RNA Editing by Short Inhibitory RNA-Mediated Knockdown of ADAR1 but Not ADAR2 Expression , 2002, Journal of Virology.
[29] V. Matys,et al. In vivo effects of the Epstein-Barr virus small RNA EBER-1 on protein synthesis and cell growth regulation. , 2002, Virology.
[30] T. E. Dever,et al. Gene-Specific Regulation by General Translation Factors , 2002, Cell.
[31] C. Samuel,et al. Antiviral Actions of Interferons , 2001, Clinical Microbiology Reviews.
[32] M. Schapira,et al. Regulated translation initiation controls stress-induced gene expression in mammalian cells. , 2000, Molecular cell.
[33] B. Williams,et al. The antiviral enzymes PKR and RNase L suppress gene expression from viral and non-viral based vectors. , 1999, Nucleic acids research.
[34] R. Emeson,et al. Serotonin-2C Receptor Pre-mRNA Editing in Rat Brain andin Vitro by Splice Site Variants of the Interferon-inducible Double-stranded RNA-specific Adenosine Deaminase ADAR1* , 1999, The Journal of Biological Chemistry.
[35] C. Samuel,et al. Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[36] Yong Liu,et al. Editing of Glutamate Receptor Subunit B Pre-mRNA by Splice-site Variants of Interferon-inducible Double-stranded RNA-specific Adenosine Deaminase ADAR1* , 1999, The Journal of Biological Chemistry.
[37] D. Ron,et al. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase , 1999, Nature.
[38] M. Katze,et al. Inhibition of Double-Stranded RNA-Dependent Protein Kinase PKR by Vaccinia Virus E3: Role of Complex Formation and the E3 N-Terminal Domain , 1998, Molecular and Cellular Biology.
[39] Brenda L. Bass,et al. RNA editing of hepatitis delta virus antigenome by dsRNA-adenosine deaminase , 1996, Nature.
[40] C. Samuel,et al. Mechanism of interferon action: functionally distinct RNA-binding and catalytic domains in the interferon-inducible, double-stranded RNA-specific adenosine deaminase , 1996, Journal of virology.
[41] C. Samuel,et al. Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase , 1995, Molecular and cellular biology.
[42] M. Higuchi,et al. Cloning of cDNAs encoding mammalian double-stranded RNA-specific adenosine deaminase , 1995, Molecular and cellular biology.
[43] K. Nishikura,et al. Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[44] R. Wek. eIF-2 kinases: regulators of general and gene-specific translation initiation. , 1994, Trends in biochemical sciences.
[45] C. Samuel,et al. The eIF-2 alpha protein kinases, regulators of translation in eukaryotes from yeasts to humans. , 1993, The Journal of biological chemistry.
[46] H. W. Chang,et al. The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms , 1993, Journal of virology.
[47] J. E. Smith,et al. A double-stranded RNA unwinding activity introduces structural alterations by means of adenosine to inosine conversions in mammalian cells and Xenopus eggs. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[48] V. Pathak,et al. The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs , 1989, Molecular and cellular biology.
[49] Brenda L. Bass,et al. An unwinding activity that covalently modifies its double-stranded RNA substrate , 1988, Cell.
[50] Roberto Cattaneo,et al. Biased hypermutation and other genetic changes in defective measles viruses in human brain infections , 1988, Cell.
[51] R. Kaufman,et al. Translational control mediated by eucaryotic initiation factor-2 is restricted to specific mRNAs in transfected cells , 1987, Molecular and cellular biology.
[52] D. Melton,et al. Antisense RNA injections in fertilized frog eggs reveal an RNA duplex unwinding activity , 1987, Cell.
[53] C. E. Samuel. Mechanism of interferon action: phosphorylation of protein synthesis initiation factor eIF-2 in interferon-treated human cells by a ribosome-associated kinase processing site specificity similar to hemin-regulated rabbit reticulocyte kinase. , 1979, Proceedings of the National Academy of Sciences of the United States of America.
[54] G. Kramer,et al. Specificity of the protein kinase activity associated with the hemin-controlled repressor of rabbit reticulocyte. , 1976, Proceedings of the National Academy of Sciences of the United States of America.
[55] B. Williams,et al. Structure and function of the protein kinase R. , 2007, Current topics in microbiology and immunology.
[56] C. Samuel,et al. Interferon action and the double-stranded RNA-dependent enzymes ADAR1 adenosine deaminase and PKR protein kinase. , 2006, Progress in nucleic acid research and molecular biology.
[57] K. Ewert,et al. Cationic lipid-DNA complexes for gene therapy: understanding the relationship between complex structure and gene delivery pathways at the molecular level. , 2004, Current medicinal chemistry.
[58] Brenda L Bass,et al. RNA editing by adenosine deaminases that act on RNA. , 2002, Annual review of biochemistry.