论文信息 - Prospective study of a family cancer syndrome.

Prospective study of a family cancer syndrome.

Risk of cancer was studied prospectively in four families described in 1969 as having diverse neoplasms, especially breast cancer and soft-tissue sarcoma. Between 1969 and 1981, in ten of 31 surviving family members, there developed 16 additional cancers (expected, 0.5). There were five breast carcinomas, four soft-tissue sarcomas, and seven other cancers. In eight patients, multiple primary cancers developed, including three softtissue sarcomas and one mesothelioma at sites of prior radiotherapy. (JAMA1982;247:2692-2694)

J. Fraumeni | F. Li | F. Li | F. Li

[1] J. Fraumeni,et al. TRANSMISSION OF IN-VITRO RADIORESISTANCE IN A CANCER-PRONE FAMILY , 1981, The Lancet.

[2] P. T. Condit,et al. Chromosome studies in a “cancer family” , 1971, Cancer.

[3] M. Melamed,et al. Radiation-induced soft-tissue and bone sarcoma. , 1978, Radiology.

[4] H. Lynch,et al. Breast cancer genetics and cancer control. Tumor association. , 1975, Archives of surgery.

[5] W. Blattner,et al. Genealogy of cancer in a family. , 1979, Journal of the American Medical Association (JAMA).

[6] F. Li,et al. Letter: Familial breast cancer, soft-tissue sarcomas, and other neoplasms. , 1975, Annals of internal medicine.

[7] R. Connelly,et al. Third national cancer survey: incidence data. , 1975, National Cancer Institute monograph.

[8] H. Lynch,et al. Association of soft tissue sarcoma, leukemia, and brain tumors in families affected with breast cancer. , 1973, The American surgeon.

[9] H. Lynch,et al. Genetic and pathologic findings in a kindred with hereditary sarcoma breast cancer, brain tumors, leukemia, lung, laryngeal, and adrenal cortical carcinoma , 1978, Cancer.

[10] J. Fraumeni,et al. Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome? , 1969, Annals of internal medicine.