论文信息 - Kumada-Corriu reactions in a pressure-driven microflow reactor.

Kumada-Corriu reactions in a pressure-driven microflow reactor.

Reaction rates for the Kumada reaction (of Grignard reagents with aryl halides) catalysed by an immobilised nickel(II) catalyst have been shown to be enhanced when the reaction is carried out in a pressure driven microreactor (internal diameter 100-200 microm) rather than with conventional batch reaction techniques.

[1] R. Corriu,et al. Activation of Grignard reagents by transition-metal complexes. A new and simple synthesis of trans-stilbenes and polyphenyls , 1972 .

[2] Paul Watts,et al. The application of micro reactors to synthetic chemistry , 2001 .

[3] Makoto Kumada,et al. Selective carbon-carbon bond formation by cross-coupling of Grignard reagents with organic halides. Catalysis by nickel-phosphine complexes , 1972 .

[4] Norio Miyaura,et al. Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds , 1995 .

[5] H. A. Dieck,et al. Palladium catalyzed synthesis of aryl, heterocyclic and vinylic acetylene derivatives , 1975 .

[6] I. Moritani,et al. The reaction of σ-vinylpalladium complexes with alkyllithiums. Stereospecific syntheses of olefins from vinyl halides and alkyllithiums , 1975 .