Artificial ribozymes and deoxyribozymes.

RNA and DNA molecules with catalytic properties have been isolated by in vitro selection from combinatorial nucleic acid libraries. A broad range of chemical reactions is catalyzed and nucleic acids can accelerate bond formation between small organic substrates. The catalytic performance of nucleic acids can be enhanced by the incorporation of additional functional groups.

[1]  D. Bartel,et al.  RNA-catalysed nucleotide synthesis , 1998, Nature.

[2]  T. Tarasow,et al.  RNA-catalysed carbon–carbon bond formation , 1997, Nature.

[3]  I. Majerfeld,et al.  23S rRNA similarity from selection for peptidyl transferase mimicry. , 1997, Biochemistry.

[4]  R R Breaker,et al.  Structural diversity of self-cleaving ribozymes. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[5]  M. Yarus,et al.  RNA enzymes with two small-molecule substrates. , 1998, Chemistry & biology.

[6]  D. Bartel,et al.  One sequence, two ribozymes: implications for the emergence of new ribozyme folds. , 2000, Science.

[7]  T. Steitz,et al.  The structural basis of ribosome activity in peptide bond synthesis. , 2000, Science.

[8]  M. Illangasekare,et al.  Aminoacyl-RNA synthesis catalyzed by an RNA , 1995, Science.

[9]  G. F. Joyce,et al.  A DNA enzyme with N-glycosylase activity. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[10]  M. Famulok,et al.  Catalysis Based on Nucleic Acid Structures , 1999 .

[11]  A. Jäschke,et al.  In Vitro Selected Oligonucleotides as Tools in Organic Chemistry , 1999 .

[12]  Y. Ito,et al.  In vitro selection of a ligase ribozyme carrying alkylamino groups in the side chains. , 2000, Bioconjugate chemistry.

[13]  W. Jencks,et al.  Binding energy, specificity, and enzymic catalysis: the circe effect. , 2006, Advances in enzymology and related areas of molecular biology.

[14]  G. F. Joyce,et al.  RNA cleavage by a DNA enzyme with extended chemical functionality. , 2000, Journal of the American Chemical Society.

[15]  A. Jäschke,et al.  Evolution of DNA and RNA as catalysts for chemical reactions. , 2000, Current opinion in chemical biology.

[16]  M Yarus,et al.  Peptidyl transferase: ancient and exiguous. , 2000, Chemistry & biology.

[17]  B. Eaton,et al.  Selection of RNA amide synthases. , 1997, Chemistry & biology.

[18]  Andres Jäschke,et al.  Enantioselective Ribozyme Catalysis of a Bimolecular Cycloaddition Reaction , 2000 .

[19]  M. Famulok,et al.  A novel ribozyme with ester transferase activity. , 1998, Chemistry & biology.

[20]  B. Eaton,et al.  The joys of in vitro selection: chemically dressing oligonucleotides to satiate protein targets. , 1997, Current opinion in chemical biology.

[21]  C. Geyer,et al.  Use of intrinsic binding energy for catalysis by a cofactor-independent DNA enzyme. , 2000, Journal of molecular biology.

[22]  M. Yarus,et al.  5'-RNA self-capping from guanosine diphosphate. , 1997, Biochemistry.

[23]  J. Szostak,et al.  Expanding the structural and functional diversity of RNA: analog uridine triphosphates as candidates for in vitro selection of nucleic acids. , 2000, Nucleic acids research.

[24]  A. Beaudry,et al.  In vitro selection of a novel nuclease-resistant RNA phosphodiesterase. , 2000, Chemistry & biology.

[25]  A. Jäschke,et al.  A small catalytic RNA motif with Diels-Alderase activity. , 1999, Chemistry & biology.

[26]  J. Szostak,et al.  In vitro selection of functional nucleic acids. , 1999, Annual review of biochemistry.

[27]  J. Williamson.  Induced fit in RNA–protein recognition , 2000, Nature Structural Biology.

[28]  D. Patel,et al.  Adaptive recognition by nucleic acid aptamers. , 2000, Science.

[29]  S. Strobel.  A chemogenetic approach to RNA function/structure analysis. , 1999, Current opinion in structural biology.

[30]  R R Breaker,et al.  Allosteric nucleic acid catalysts. , 2000, Current opinion in structural biology.

[31]  J. Szostak,et al.  Ribozyme-catalysed amino-acid transfer reactions , 1996, Nature.

[32]  J. Doudna,et al.  Ribozyme structures and mechanisms. , 2000, Annual review of biochemistry.

[33]  David P. Bartel,et al.  Constructing an RNA world. , 1999, Trends in Cell Biology.

[34]  Y. Bessho,et al.  Ribozyme-catalyzed tRNA aminoacylation , 2000, Nature Structural Biology.

[35]  R R Breaker,et al.  Capping DNA with DNA. , 2000, Biochemistry.