Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation

[1]  Y. Jeng,et al.  High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells. , 2019, Cell metabolism.

[2]  Prashant Mishra,et al.  Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver. , 2019, Cell metabolism.

[3]  C. Argmann,et al.  Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells. , 2019, Cell Metabolism.

[4]  Daniela C. Zarnescu,et al.  Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS , 2019, bioRxiv.

[5]  J. Opferman,et al.  Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD. , 2018, Molecular cell.

[6]  S. Jitrapakdee,et al.  Roles of pyruvate carboxylase in human diseases: from diabetes to cancers and infection , 2018, Journal of Molecular Medicine.

[7]  J. Olefsky,et al.  An Integrated View of Immunometabolism , 2018, Cell.

[8]  M. Mahajan,et al.  Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas , 2017, Nature Communications.

[9]  M. Levy,et al.  Pancreatic β-Cell–Derived IP-10/CXCL10 Isletokine Mediates Early Loss of Graft Function in Islet Cell Transplantation , 2017, Diabetes.

[10]  William M Alexander,et al.  multiplierz v2.0: A Python‐based ecosystem for shared access and analysis of native mass spectrometry data , 2017, Proteomics.

[11]  M. Donath,et al.  The Role of Inflammation in β-cell Dedifferentiation , 2017, Scientific Reports.

[12]  H. Kolb,et al.  Immunotherapy for Type 1 Diabetes: Why Do Current Protocols Not Halt the Underlying Disease Process? , 2017, Cell metabolism.

[13]  P. MacDonald,et al.  Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease. , 2016, The Journal of clinical investigation.

[14]  S. Baird,et al.  High-throughput Functional Genomics Identifies Regulators of Primary Human Beta Cell Proliferation* , 2016, The Journal of Biological Chemistry.

[15]  R. Testa,et al.  Short-term high glucose exposure impairs insulin signaling in endothelial cells , 2015, Cardiovascular Diabetology.

[16]  A. Vazquez,et al.  Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis , 2015, Nature Cell Biology.

[17]  N. Danial,et al.  Regulation of mitochondrial nutrient and energy metabolism by BCL-2 family proteins , 2015, Trends in Endocrinology & Metabolism.

[18]  N. Danial,et al.  Phospho-BAD BH3 mimicry protects β cells and restores functional β cell mass in diabetes. , 2015, Cell reports.

[19]  Jeroen Krijgsveld,et al.  Ultrasensitive proteome analysis using paramagnetic bead technology , 2014, Molecular systems biology.

[20]  D. Avizonis,et al.  Stable Isotope Tracer Analysis in Isolated Mitochondria from Mammalian Systems , 2014, Metabolites.

[21]  Muhammed A. Yıldırım,et al.  Regulation of hepatic energy metabolism and gluconeogenesis by BAD. , 2014, Cell metabolism.

[22]  N. Danial,et al.  A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators , 2013, Nature Structural &Molecular Biology.

[23]  B. Faubert,et al.  PGC-1α supports glutamine metabolism in breast cancer , 2013, Cancer & metabolism.

[24]  M. Prentki,et al.  Metabolic signaling in fuel-induced insulin secretion. , 2013, Cell metabolism.

[25]  S. Ficarro,et al.  Genome-scale Proteome Quantification by DEEP SEQ Mass Spectrometry , 2013, Nature Communications.

[26]  D. Mathis Immunological goings-on in visceral adipose tissue. , 2013, Cell metabolism.

[27]  M. Donath,et al.  Inflammation in obesity and diabetes: islet dysfunction and therapeutic opportunity. , 2013, Cell metabolism.

[28]  Halit Ongen,et al.  Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome , 2013, Genome research.

[29]  D. R. Laybutt,et al.  The molecular mechanisms of pancreatic β-cell glucotoxicity: Recent findings and future research directions , 2012, Molecular and Cellular Endocrinology.

[30]  Y. Dor,et al.  Glucose metabolism: key endogenous regulator of β‐cell replication and survival , 2012, Diabetes, obesity & metabolism.

[31]  F. Matschinsky,et al.  Susceptibility of Glucokinase-MODY Mutants to Inactivation by Oxidative Stress in Pancreatic β-Cells , 2011, Diabetes.

[32]  Nicola Zamboni,et al.  High-throughput, accurate mass metabolome profiling of cellular extracts by flow injection-time-of-flight mass spectrometry. , 2011, Analytical chemistry.

[33]  D. Accili,et al.  How Does Type 1 Diabetes Develop? , 2011, Diabetes.

[34]  Michal Linial,et al.  The complete peptide dictionary – A meta‐proteomics resource , 2010, Proteomics.

[35]  M. J. MacDonald,et al.  Regulation of insulin secretion: role of mitochondrial signalling , 2010, Diabetologia.

[36]  F. Matschinsky,et al.  Assessing the potential of glucokinase activators in diabetes therapy , 2009, Nature Reviews Drug Discovery.

[37]  F. Ortis,et al.  The role of inflammation in insulitis and β-cell loss in type 1 diabetes , 2009, Nature Reviews Endocrinology.

[38]  M. Jensen,et al.  Metabolic cycling in control of glucose-stimulated insulin secretion. , 2008, American journal of physiology. Endocrinology and metabolism.

[39]  S. R. Datta,et al.  Dual role of proapoptotic BAD in insulin secretion and beta cell survival , 2008, Nature Medicine.

[40]  D. Mckerrecher,et al.  Design of a potent, soluble glucokinase activator with excellent in vivo efficacy. , 2006, Bioorganic & medicinal chemistry letters.

[41]  À. García‐Cazorla,et al.  Pyruvate carboxylase deficiency: Metabolic characteristics and new neurological aspects , 2006, Annals of neurology.

[42]  M. Gorenstein,et al.  Absolute Quantification of Proteins by LCMSE , 2006, Molecular & Cellular Proteomics.

[43]  Patrik Rorsman,et al.  Glucose-sensing mechanisms in pancreatic β-cells , 2005, Philosophical Transactions of the Royal Society B: Biological Sciences.

[44]  Meng Chen,et al.  Inflammatory Blockade Improves Human Pancreatic Islet Function and Viability , 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[45]  H. Huopio,et al.  Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation. , 2004, Diabetes.

[46]  Ming Li,et al.  PEAKS: powerful software for peptide de novo sequencing by tandem mass spectrometry. , 2003, Rapid communications in mass spectrometry : RCM.

[47]  J. Grippo,et al.  Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy , 2003, Science.

[48]  S. Morris,et al.  Arginase expression and modulation of IL-1beta-induced nitric oxide generation in rat and human islets of Langerhans. , 2002, Nitric oxide : biology and chemistry.

[49]  V. Shih,et al.  Argininosuccinate lyase deficiency: longterm outcome of 13 patients detected by newborn screening. , 2000, Molecular genetics and metabolism.

[50]  D. Kerr,et al.  Assays of pyruvate dehydrogenase complex and pyruvate carboxylase activity. , 2012, Methods in molecular biology.

[51]  U. Sauer,et al.  Determination of metabolic flux ratios from 13C-experiments and gas chromatography-mass spectrometry data: protocol and principles. , 2007, Methods in molecular biology.