Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation
暂无分享,去创建一个
Russell G. Jones | S. Ficarro | J. Marto | N. Danial | H. Seo | A. F. Stewart | L. Walensky | Gäelle Bridon | D. Avizonis | G. Bird | T. Kin | A. García-Ocaña | Jurre J. Kamphorst | S. Dhe-Paganon | Esra Karakose | L. Evans | Mehmet G. Badur | D. Choi | Carolina Rosselot | Accalia Fu | J. Álvarez-Pérez | A. M. James Shapiro | Gregory H. Bird
[1] Y. Jeng,et al. High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells. , 2019, Cell metabolism.
[2] Prashant Mishra,et al. Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver. , 2019, Cell metabolism.
[3] C. Argmann,et al. Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells. , 2019, Cell Metabolism.
[4] Daniela C. Zarnescu,et al. Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS , 2019, bioRxiv.
[5] J. Opferman,et al. Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD. , 2018, Molecular cell.
[6] S. Jitrapakdee,et al. Roles of pyruvate carboxylase in human diseases: from diabetes to cancers and infection , 2018, Journal of Molecular Medicine.
[7] J. Olefsky,et al. An Integrated View of Immunometabolism , 2018, Cell.
[8] M. Mahajan,et al. Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas , 2017, Nature Communications.
[9] M. Levy,et al. Pancreatic β-Cell–Derived IP-10/CXCL10 Isletokine Mediates Early Loss of Graft Function in Islet Cell Transplantation , 2017, Diabetes.
[10] William M Alexander,et al. multiplierz v2.0: A Python‐based ecosystem for shared access and analysis of native mass spectrometry data , 2017, Proteomics.
[11] M. Donath,et al. The Role of Inflammation in β-cell Dedifferentiation , 2017, Scientific Reports.
[12] H. Kolb,et al. Immunotherapy for Type 1 Diabetes: Why Do Current Protocols Not Halt the Underlying Disease Process? , 2017, Cell metabolism.
[13] P. MacDonald,et al. Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease. , 2016, The Journal of clinical investigation.
[14] S. Baird,et al. High-throughput Functional Genomics Identifies Regulators of Primary Human Beta Cell Proliferation* , 2016, The Journal of Biological Chemistry.
[15] R. Testa,et al. Short-term high glucose exposure impairs insulin signaling in endothelial cells , 2015, Cardiovascular Diabetology.
[16] A. Vazquez,et al. Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis , 2015, Nature Cell Biology.
[17] N. Danial,et al. Regulation of mitochondrial nutrient and energy metabolism by BCL-2 family proteins , 2015, Trends in Endocrinology & Metabolism.
[18] N. Danial,et al. Phospho-BAD BH3 mimicry protects β cells and restores functional β cell mass in diabetes. , 2015, Cell reports.
[19] Jeroen Krijgsveld,et al. Ultrasensitive proteome analysis using paramagnetic bead technology , 2014, Molecular systems biology.
[20] D. Avizonis,et al. Stable Isotope Tracer Analysis in Isolated Mitochondria from Mammalian Systems , 2014, Metabolites.
[21] Muhammed A. Yıldırım,et al. Regulation of hepatic energy metabolism and gluconeogenesis by BAD. , 2014, Cell metabolism.
[22] N. Danial,et al. A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators , 2013, Nature Structural &Molecular Biology.
[23] B. Faubert,et al. PGC-1α supports glutamine metabolism in breast cancer , 2013, Cancer & metabolism.
[24] M. Prentki,et al. Metabolic signaling in fuel-induced insulin secretion. , 2013, Cell metabolism.
[25] S. Ficarro,et al. Genome-scale Proteome Quantification by DEEP SEQ Mass Spectrometry , 2013, Nature Communications.
[26] D. Mathis. Immunological goings-on in visceral adipose tissue. , 2013, Cell metabolism.
[27] M. Donath,et al. Inflammation in obesity and diabetes: islet dysfunction and therapeutic opportunity. , 2013, Cell metabolism.
[28] Halit Ongen,et al. Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome , 2013, Genome research.
[29] D. R. Laybutt,et al. The molecular mechanisms of pancreatic β-cell glucotoxicity: Recent findings and future research directions , 2012, Molecular and Cellular Endocrinology.
[30] Y. Dor,et al. Glucose metabolism: key endogenous regulator of β‐cell replication and survival , 2012, Diabetes, obesity & metabolism.
[31] F. Matschinsky,et al. Susceptibility of Glucokinase-MODY Mutants to Inactivation by Oxidative Stress in Pancreatic β-Cells , 2011, Diabetes.
[32] Nicola Zamboni,et al. High-throughput, accurate mass metabolome profiling of cellular extracts by flow injection-time-of-flight mass spectrometry. , 2011, Analytical chemistry.
[33] D. Accili,et al. How Does Type 1 Diabetes Develop? , 2011, Diabetes.
[34] Michal Linial,et al. The complete peptide dictionary – A meta‐proteomics resource , 2010, Proteomics.
[35] M. J. MacDonald,et al. Regulation of insulin secretion: role of mitochondrial signalling , 2010, Diabetologia.
[36] F. Matschinsky,et al. Assessing the potential of glucokinase activators in diabetes therapy , 2009, Nature Reviews Drug Discovery.
[37] F. Ortis,et al. The role of inflammation in insulitis and β-cell loss in type 1 diabetes , 2009, Nature Reviews Endocrinology.
[38] M. Jensen,et al. Metabolic cycling in control of glucose-stimulated insulin secretion. , 2008, American journal of physiology. Endocrinology and metabolism.
[39] S. R. Datta,et al. Dual role of proapoptotic BAD in insulin secretion and beta cell survival , 2008, Nature Medicine.
[40] D. Mckerrecher,et al. Design of a potent, soluble glucokinase activator with excellent in vivo efficacy. , 2006, Bioorganic & medicinal chemistry letters.
[41] À. García‐Cazorla,et al. Pyruvate carboxylase deficiency: Metabolic characteristics and new neurological aspects , 2006, Annals of neurology.
[42] M. Gorenstein,et al. Absolute Quantification of Proteins by LCMSE , 2006, Molecular & Cellular Proteomics.
[43] Patrik Rorsman,et al. Glucose-sensing mechanisms in pancreatic β-cells , 2005, Philosophical Transactions of the Royal Society B: Biological Sciences.
[44] Meng Chen,et al. Inflammatory Blockade Improves Human Pancreatic Islet Function and Viability , 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
[45] H. Huopio,et al. Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation. , 2004, Diabetes.
[46] Ming Li,et al. PEAKS: powerful software for peptide de novo sequencing by tandem mass spectrometry. , 2003, Rapid communications in mass spectrometry : RCM.
[47] J. Grippo,et al. Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy , 2003, Science.
[48] S. Morris,et al. Arginase expression and modulation of IL-1beta-induced nitric oxide generation in rat and human islets of Langerhans. , 2002, Nitric oxide : biology and chemistry.
[49] V. Shih,et al. Argininosuccinate lyase deficiency: longterm outcome of 13 patients detected by newborn screening. , 2000, Molecular genetics and metabolism.
[50] D. Kerr,et al. Assays of pyruvate dehydrogenase complex and pyruvate carboxylase activity. , 2012, Methods in molecular biology.
[51] U. Sauer,et al. Determination of metabolic flux ratios from 13C-experiments and gas chromatography-mass spectrometry data: protocol and principles. , 2007, Methods in molecular biology.