The Brain is Hypothermic in Patients with Mitochondrial Diseases

[1]  M. Beal,et al.  Mitochondrial diseases of the brain. , 2013, Free radical biology & medicine.

[2]  V. Kalatsky,et al.  Influence of body temperature on the evoked activity in mouse visual cortex , 2013, Brain Imaging and Behavior.

[3]  Hanzhang Lu,et al.  The BOLD post-stimulus undershoot, one of the most debated issues in fMRI , 2012, NeuroImage.

[4]  N. Bresolin,et al.  Brain temperature: What do we know? , 2012, Neuroreport.

[5]  A. Schapira Mitochondrial diseases , 2012, The Lancet.

[6]  S. Ogawa,et al.  Biophysical and Physiological Origins of Blood Oxygenation Level-Dependent fMRI Signals , 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[7]  N. Bresolin,et al.  Mutated mitofusin 2 presents with intrafamilial variability and brain mitochondrial dysfunction , 2008, Neurology.

[8]  D. Yablonskiy,et al.  Improved calibration technique for in vivo proton MRS thermometry for brain temperature measurement , 2008, Magnetic resonance in medicine.

[9]  R. Lenkinski,et al.  Limits on activation‐induced temperature and metabolic changes in the human primary visual cortex , 2006, Magnetic resonance in medicine.

[10]  F. Hyder,et al.  Regional Temperature Changes in the Brain during Somatosensory Stimulation , 2006, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[11]  J. Pekar,et al.  Sustained Poststimulus Elevation in Cerebral Oxygen Utilization after Vascular Recovery , 2004, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[12]  Conrad Kufta,et al.  Intraoperative infrared functional imaging of human brain , 2003, Annals of neurology.

[13]  I. Silver,et al.  Effects of Hypothermia on Energy Metabolism in Mammalian Central Nervous System , 2003, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[14]  R. Wise,et al.  Brain temperature fluctuation: a reflection of functional neural activation , 2002, The European journal of neuroscience.

[15]  S. Schultz Principles of Neural Science, 4th ed. , 2001 .

[16]  G Scarlato,et al.  Brain Activation in Normal Subjects and in Patients Affected by Mitochondrial Disease without Clinical Central Nervous System Involvement: A Phosphorus Magnetic Resonance Spectroscopy Study , 2001, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[17]  E. Meyer,et al.  Impaired activation of oxygen consumption and blood flow in visual cortex of patients with mitochondrial encephalomyopathy , 2000, Annals of neurology.

[18]  M E Raichle,et al.  Coupling between changes in human brain temperature and oxidative metabolism during prolonged visual stimulation. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[19]  T R Vidyasagar,et al.  Membrane properties and spike generation in rat visual cortical cells during reversible cooling , 2000, The Journal of physiology.

[20]  L. Sokoloff,et al.  Cerebral Oxygen/Glucose Ratio is Low during Sensory Stimulation and Rises above Normal during Recovery: Excess Glucose Consumption during Stimulation is Not Accounted for by Lactate Efflux from or Accumulation in Brain Tissue , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[21]  O B Paulson,et al.  Activation-Induced Resetting of Cerebral Oxygen and Glucose Uptake in the Rat , 1998, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[22]  P. Weatherall,et al.  Noninvasive Measurements of Human Brain Temperature Using Volume-Localized Proton Magnetic Resonance Spectroscopy , 1997, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[23]  F. Shishido,et al.  Cerebral oxygen and glucose metabolism and blood flow in mitochondrial encephalomyopathy: a PET study , 1996, Neuroradiology.

[24]  A. Kleinschmidt,et al.  Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal brain activation in man , 1996, Magnetic resonance in medicine.

[25]  J. Penrice,et al.  The Estimation of Local Brain Temperature by in Vivo 1H Magnetic Resonance Spectroscopy , 1995, Magnetic resonance in medicine.

[26]  S. Hirai,et al.  [Cerebral circulation and metabolism in patients with mitochondrial myopathies]. , 1993, Rinsho shinkeigaku = Clinical neurology.

[27]  M D Ginsberg,et al.  Selective brain cooling increases cortical cerebral blood flow in rats. , 1993, The American journal of physiology.

[28]  J D Michenfelder,et al.  The relationship among canine brain temperature, metabolism, and function during hypothermia. , 1991, Anesthesiology.

[29]  Y. Okada,et al.  Effects of temperature on the oxygen consumption in thin slices from different brain regions , 1988, Neuroscience Letters.

[30]  O. Siggaard‐Andersen,et al.  A mathematical model of the hemoglobin-oxygen dissociation curve of human blood and of the oxygen partial pressure as a function of temperature. , 1984, Clinical chemistry.

[31]  E. Kiyatkin,et al.  Brain temperature homeostasis: physiological fluctuations and pathological shifts. , 2010, Frontiers in bioscience.

[32]  J. Melick,et al.  Suppression of cerebral metabolic rate for oxygen (CMRO2) by mild hypothermia compared with thiopental. , 1996, Journal of neurosurgical anesthesiology.

[33]  J S George,et al.  IR thermal imaging of a monkey's head: local temperature changes in response to somatosensory stimulation. , 1993, Advances in experimental medicine and biology.

[34]  B. Siesjö,et al.  Brain energy metabolism , 1978 .