Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors.
暂无分享,去创建一个
Barbara Sennino | J. Christensen | W. You | D. McDonald | H. Chapman | Ying-Ying Wei | B. Sennino | Donald M McDonald | James G Christensen | Weon-Kyoo You | Harold A Chapman | Ying Wei | Toshina Ishiguro-Oonuma | Casey W Williamson | Ryan M Naylor | Vikash Bhagwandin | Sebastien P Tabruyn | Dana T Aftab | C. Williamson | R. Naylor | D. Aftab | S. Tabruyn | T. Ishiguro-Oonuma | Vikash J. Bhagwandin | Ying‐Ying Wei
[1] U. McDermott,et al. Acquired resistance of non-small cell lung cancer cells to MET kinase inhibition is mediated by a switch to epidermal growth factor receptor dependency. , 2010, Cancer research.
[2] Masahiro Inoue,et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. , 2009, Cancer cell.
[3] N. Sato,et al. Radiation stimulates HGF receptor/c‐Met expression that leads to amplifying cellular response to HGF stimulation via upregulated receptor tyrosine phosphorylation and MAP kinase activity in pancreatic cancer cells , 2003, International journal of cancer.
[4] K. Nagashima,et al. GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood–brain barrier , 2011, Proceedings of the National Academy of Sciences.
[5] J. Christensen,et al. Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors. , 2009, Biochemistry.
[6] R. Cardiff,et al. Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer , 2009, Proceedings of the National Academy of Sciences.
[7] T. Nakagawa,et al. E7050: A dual c‐Met and VEGFR‐2 tyrosine kinase inhibitor promotes tumor regression and prolongs survival in mouse xenograft models , 2010, Cancer science.
[8] M. Schott,et al. Activity of XL184 (Cabozantinib), an Oral Tyrosine Kinase Inhibitor, in Patients With Medullary Thyroid Cancer , 2012 .
[9] D. Stolz,et al. Cross-talk between Epidermal Growth Factor Receptor and c-Met Signal Pathways in Transformed Cells* , 2000, The Journal of Biological Chemistry.
[10] S. Thorgeirsson,et al. Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance. , 2005, The American journal of pathology.
[11] K. Yamaguchi,et al. Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. , 2009, Cancer research.
[12] J. Bishop,et al. Cellular adherence elicits ligand-independent activation of the Met cell-surface receptor. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[13] Jie Qi,et al. Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors. , 2011, Cancer research.
[14] D. Smith,et al. Cabozantinib (XL184) in metastatic castration-resistant prostate cancer (mCRPC): Results from a phase II randomized discontinuation trial. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[15] L. Zentilin,et al. Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models. , 2009, The Journal of clinical investigation.
[16] M. Nieto,et al. The snail superfamily of zinc-finger transcription factors , 2002, Nature Reviews Molecular Cell Biology.
[17] John M L Ebos,et al. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. , 2009, Cancer cell.
[18] Gavin Thurston,et al. Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. , 2004, The American journal of pathology.
[19] Shinji Yamazaki,et al. Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma , 2007, Molecular Cancer Therapeutics.
[20] D. Bottaro,et al. Targeting the c-Met signaling pathway in cancer. , 2008, Clinical cancer research : an official journal of the American Association for Cancer Research.
[21] M. Westphal,et al. Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. , 2000, Neoplasia.
[22] Karl J. Dykema,et al. Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer , 2009, Proceedings of the National Academy of Sciences.
[23] Gerhard Christofori,et al. EMT, the cytoskeleton, and cancer cell invasion , 2009, Cancer and Metastasis Reviews.
[24] S. Thorgeirsson,et al. β-Cell-Specific Ablation of the Hepatocyte Growth Factor Receptor Results in Reduced Islet Size, Impaired Insulin Secretion, and Glucose Intolerance , 2005 .
[25] G. Merlino,et al. Constitutive c-Met signaling through a nonautocrine mechanism promotes metastasis in a transgenic transplantation model. , 2002, Cancer research.
[26] J. Pouysségur,et al. Hypoxia signalling in cancer and approaches to enforce tumour regression , 2006, Nature.
[27] D. Hanahan,et al. Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. , 1985, Nature.
[28] L. Trusolino,et al. MET signalling: principles and functions in development, organ regeneration and cancer , 2010, Nature Reviews Molecular Cell Biology.
[29] Y. Shyr,et al. Transforming Growth Factor-β Signaling–Deficient Fibroblasts Enhance Hepatocyte Growth Factor Signaling in Mammary Carcinoma Cells to Promote Scattering and Invasion , 2008, Molecular Cancer Research.
[30] J. Christensen,et al. A preclinical review of sunitinib, a multitargeted receptor tyrosine kinase inhibitor with anti-angiogenic and antitumour activities. , 2007, Annals of oncology : official journal of the European Society for Medical Oncology.
[31] E. Kistner,et al. c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion. , 2007, Cancer research.
[32] E. Lengyel,et al. C‐Met overexpression in node‐positive breast cancer identifies patients with poor clinical outcome independent of Her2/neu , 2005, International journal of cancer.
[33] Do-Hyun Nam,et al. Prognostic significance of c‐Met expression in glioblastomas , 2009, Cancer.
[34] D. Hanahan,et al. Polymorphic genetic control of tumor invasion in a mouse model of pancreatic neuroendocrine carcinogenesis , 2010, Proceedings of the National Academy of Sciences.
[35] T. Welling,et al. c-Met is a marker of pancreatic cancer stem cells and therapeutic target. , 2011, Gastroenterology.
[36] D. Hanahan,et al. Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. , 1999, Science.
[37] L. Ellis,et al. VEGF-targeted therapy: mechanisms of anti-tumour activity , 2008, Nature Reviews Cancer.
[38] Yongchang Shi,et al. Cabozantinib (XL184), a Novel MET and VEGFR2 Inhibitor, Simultaneously Suppresses Metastasis, Angiogenesis, and Tumor Growth , 2011, Molecular Cancer Therapeutics.
[39] J. Fleming,et al. Molecular Consequences of Silencing Mutant K-ras in Pancreatic Cancer Cells: Justification for K-ras–Directed Therapy , 2005, Molecular Cancer Research.
[40] R. Brekken,et al. Combination of a monoclonal anti‐phosphatidylserine antibody with gemcitabine strongly inhibits the growth and metastasis of orthotopic pancreatic tumors in mice , 2006, International journal of cancer.
[41] L. Ellis,et al. Vascular endothelial growth factor is an in vivo survival factor for tumor endothelium in a murine model of colorectal carcinoma liver metastases , 2000, Cancer.
[42] L. Lin,et al. Modulation of c-MET proto-oncogene (HGF receptor) mRNA abundance by cytokines and hormones: evidence for rapid decay of the 8 kb c-MET transcript. , 1994, Oncogene.
[43] K. Yamaguchi,et al. Preclinical Development Cabozantinib ( XL 184 ) , a Novel MET and VEGFR 2 Inhibitor , Simultaneously Suppresses Metastasis , Angiogenesis , and Tumor Growth , 2011 .
[44] Z. Han,et al. Cross‐talk between the VEGF‐A and HGF signalling pathways in endothelial cells , 2009, Biology of the cell.
[45] A. Dulak,et al. HGF-independent Potentiation of EGFR Action by c-Met , 2011, Oncogene.
[46] P. Kelly,et al. Antiangiogenic therapy using bevacizumab in recurrent high-grade glioma: impact on local control and patient survival. , 2009, Journal of neurosurgery.
[47] Morag Park,et al. Crosstalk in Met receptor oncogenesis. , 2009, Trends in cell biology.
[48] L. Ferrell,et al. Activation of the Met Receptor by Cell Attachment Induces and Sustains Hepatocellular Carcinomas in Transgenic Mice , 2001, The Journal of cell biology.
[49] J. Santibañez,et al. TGF-β/TGF-β receptor system and its role in physiological and pathological conditions. , 2011, Clinical science.
[50] P. Comoglio,et al. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. , 2003, Cancer cell.
[51] Bjørn Tore Gjertsen,et al. Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival , 2009, Proceedings of the National Academy of Sciences.
[52] References , 1971 .
[53] T. Ching,et al. Distinct ligand binding sites in integrin α3β1 regulate matrix adhesion and cell–cell contact , 2003, The Journal of cell biology.
[54] L. Naldini,et al. Targeting the tumor and its microenvironment by a dual-function decoy Met receptor. , 2004, Cancer cell.
[55] J. Minna,et al. Epidermal growth factor receptor regulates MET levels and invasiveness through hypoxia-inducible factor-1α in non-small cell lung cancer cells , 2010, Oncogene.
[56] Lance A. Liotta,et al. Cancer: Out of air is not out of action , 2003, Nature.
[57] J. Thiery. Epithelial–mesenchymal transitions in tumour progression , 2002, Nature Reviews Cancer.
[58] Gerhard Christofori,et al. A causal role for E-cadherin in the transition from adenoma to carcinoma , 1998, Nature.
[59] T. Mccauley,et al. Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102. , 2007, Cancer research.
[60] E. Schwarz,et al. The orally bioavailable met inhibitor PF‐2341066 inhibits osteosarcoma growth and osteolysis/matrix production in a xenograft model , 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[61] Oriol Casanovas,et al. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. , 2005, Cancer cell.
[62] M. Bloomston,et al. TIMP-1 overexpression in pancreatic cancer attenuates tumor growth, decreases implantation and metastasis, and inhibits angiogenesis. , 2002, The Journal of surgical research.
[63] Napoleone Ferrara,et al. Angiogenesis as a therapeutic target , 2005, Nature.
[64] Gabriele Bergers,et al. Modes of resistance to anti-angiogenic therapy , 2008, Nature Reviews Cancer.
[65] I. Kasman,et al. MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival. , 2007, Cancer research.
[66] M. Ratain,et al. Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[67] P. Comoglio,et al. The MET receptor tyrosine kinase in invasion and metastasis , 2007, Journal of cellular physiology.
[68] Alison Murphy,et al. Inhibition of Transforming Growth Factor β Signaling Reduces Pancreatic Adenocarcinoma Growth and Invasiveness , 2007, Molecular Pharmacology.
[69] E. Rimm,et al. Expression of c‐met is a strong independent prognostic factor in breast carcinoma , 1998, Cancer.
[70] D. Hanahan,et al. Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. , 2002, Cancer cell.
[71] D. Bottaro,et al. Targeting the c-Met Signaling Pathway in Cancer , 2006, Clinical Cancer Research.
[72] W. You,et al. VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. , 2011, Cancer research.