Acquired Immune Deficiency Syndrome: An Upcoming Menace in Women & Children

\\omcn and children constitute a vulnerable group as till' as acqllircd imlllunc deficiency syndrome (A IDS) is conccrned. (I). The epidemiology, natural history and prelentive measures suggest that AIDS may be a different epidemic in these groups. AIDS is caused by a lenlil irus, human (mmune deficiency virus (HIV). Two major types are HIV-I and HIV-2. I-IIV-I is more prevalcnt of the two with I-IIV-2 being found mainly in Central Africa and South-East Asia. '0' and 'M' are two major groups of IIIV -I with' M' being further divided into eight sub-groups from' A' to '1-1'. These sub-groups are also called clades. Clade' 8' is the predominent form in Europe and North America whereas clades '8' and '(' 9,cd<l",i\\ate i\\ South-East Asia. It is estimated that 34 million people are infected with HIV worldwide (2). \boul 12 Illillion people died of AIDS in 1997, onefourth ofll hich were children (3,4). An estimated 16,000 !t?!<.>C{I<X/soccureac1> day worldwide (5). Mere presence of IIlV lirus in body is not AIDS. Counts of CD4' J,lmphoc)tes Jess than 200htl or AIDS indicator infections should be present in addition (6). Assays for Ihedcleclion of HI V load or estimation ofCD4+ counts arc not readily available in developing countries. The nced for these is obviated in the WHO case definition for AIDS surveillance (7). Epidemiology

[1]  M. Alary,et al.  HIV infection in female prostitutes from Benin: association with symptomatic but not asymptomatic gonococcal or chlamydial infections. , 1997, AIDS.

[2]  Update: trends in AIDS incidence, deaths, and prevalence--United States, 1996. , 1997, MMWR. Morbidity and mortality weekly report.

[3]  Morie M. Higgins Peter M. Jenkins,et al.  Update: trends in AIDS incidence -- United States, 1996. , 1997, MMWR. Morbidity and mortality weekly report.

[4]  J. Metcalf,et al.  Controlled trial of interleukin-2 infusions in patients infected with the human immunodeficiency virus. , 1996, The New England journal of medicine.

[5]  S. Rasheed,et al.  Presence of cell-free human immunodeficiency virus in cervicovaginal secretions is independent of viral load in the blood of human immunodeficiency virus-infected women. , 1996, American journal of obstetrics and gynecology.

[6]  A. Valleron,et al.  Estimated timing of mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission by use of a Markov model. The HIV Infection in Newborns French Collaborative Study Group. , 1995, American journal of epidemiology.

[7]  M. Lederman,et al.  Host-Directed and Immune-Based Therapies for Human Immunodeficiency Virus Infection , 1995, Annals of Internal Medicine.

[8]  K. Holmes,et al.  Association between cervical inflammation and cervical shedding of human immunodeficiency virus DNA. , 1994, The Journal of infectious diseases.

[9]  M. Macnaughton AIDS in women. , 1992, Releve epidemiologique hebdomadaire.

[10]  J. Goedert,et al.  High risk of HIV-1 infection for first-born twins , 1991, The Lancet.

[11]  N. Jewell,et al.  Female-to-Male Transmission of Human Immunodeficiency Virus , 1991 .

[12]  F. Deist,et al.  Longitudinal study of 94 symptomatic infants with perinatally acquired human immunodeficiency virus infection. Evidence for a bimodal expression of clinical and biological symptoms. , 1990, American journal of diseases of children.

[13]  T. Quinn,et al.  Perinatal Transmission of the Human Immunodeficiency Virus Type I to Infants of Seropositive Women in Zaire , 1990 .

[14]  C. Griscelli,et al.  A prospective study of infants born to women seropositive for human immunodeficiency virus type 1 , 1990, The New England journal of medicine.

[15]  N. Luo,et al.  Perinatal transmission of HIV-I in Zambia. , 1989, BMJ.

[16]  K. Holmes,et al.  Isolation of human immunodeficiency virus from genital ulcers in Nairobi prostitutes. , 1989, The Journal of infectious diseases.

[17]  R. Brunham,et al.  FEMALE TO MALE TRANSMISSION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1: RISK FACTORS FOR SEROCONVERSION IN MEN , 1989, The Lancet.

[18]  C. Griscelli,et al.  A prospective study of infants born to women seropositive for human immunodeficiency virus type 1. , 1989 .

[19]  T. Quinn,et al.  Perinatal transmission of the human immunodeficiency virus type 1 to infants of seropositive women in Zaire. , 1989, The New England journal of medicine.