The Relationship Between Iron Deficiency Anemia and Sensorineural Hearing Loss in the Pediatric and Adolescent Population.

Purpose A correlation between iron deficiency anemia (IDA) and sudden sensorineural hearing loss (SNHL) was described in adults. In this study, we examined if there is a relationship between IDA and hearing loss in the pediatric population. Method This was a retrospective cohort study of data collected from the Informatics for Integrating Biology and the Bedside database from 2011 to 2016. Children and adolescents 4-21 years old seen at Penn State Milton S. Hershey Medical Center, Hershey, PA, were examined for hearing loss and IDA status. Hearing loss was determined by International Classification of Disease-9 and -10 codes, and IDA was determined by both low hemoglobin and serum ferritin levels for age and sex. Results We identified 20,113 patients. Prevalence of hearing loss and IDA was 1.7% and 2.3%, respectively. The prevalence of all hearing loss was 3.0% in the IDA cohort and 1.7% in those without IDA. Children and adolescents with IDA are at increased odds of developing SNHL (adjusted odds ratio: 3.67, 95% CI [1.60-7.30]). Conclusions Children with IDA demonstrate increased likelihood of SNHL. Although correction of IDA in those with hearing loss has yet to be linked to improvements in hearing outcomes, screening for and correcting IDA among pediatric patients will positively affect overall health status. Supplemental Material: https://doi.org/10.23641/asha.5087071.

[1]  J. Hagan,et al.  Bright Futures Guidelines for Health Supervision of Infants, Children, and Adolescents, 4th Ed , 2017 .

[2]  I. Oh,et al.  Relationship between obesity and hearing loss , 2016, Acta oto-laryngologica.

[3]  Douglas G. Peters,et al.  Incorporating Informatics for Integrating Biology and the Bedside (i2b2) into Predoctoral Trainee Curriculum to Evaluate Student‐Generated Hypotheses , 2015, Clinical and translational science.

[4]  K. West,et al.  Nutrition and hearing loss: a neglected cause and global health burden. , 2015, The American journal of clinical nutrition.

[5]  J. Jeong,et al.  Multivariate analysis of prognostic factors for idiopathic sudden sensorineural hearing loss in children , 2015, The Laryngoscope.

[6]  Lan Zhao,et al.  Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat. , 2015, Circulation research.

[7]  Madeeha Kamal,et al.  Higher Prevalence of Iron Deficiency as Strong Predictor of Attention Deficit Hyperactivity Disorder in Children , 2014, European Psychiatry.

[8]  P. Roehm,et al.  Viral Causes of Hearing Loss: A Review for Hearing Health Professionals , 2014, Trends in hearing.

[9]  Caiguo Zhang.  Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control , 2014, Protein & Cell.

[10]  Herng‐Ching Lin,et al.  Sudden sensorineural hearing loss associated with iron-deficiency anemia: a population-based study. , 2014, JAMA otolaryngology-- head & neck surgery.

[11]  Herng‐Ching Lin,et al.  Association between Ischemic Stroke and Iron-Deficiency Anemia: A Population-Based Study , 2013, PloS one.

[12]  R. Johnson,et al.  Perinatal iron deficiency and neurocognitive development , 2013, Front. Hum. Neurosci..

[13]  J. Pirkle,et al.  The CDC's Second National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population is a valuable tool for researchers and policy makers. , 2013, The Journal of nutrition.

[14]  Jonathan Foster,et al.  The role of nutrition in children's neurocognitive development, from pregnancy through childhood , 2013, Front. Hum. Neurosci..

[15]  N. Schellack,et al.  An overview of pharmacotherapy-induced ototoxicity , 2013 .

[16]  H. Peltola,et al.  Hearing loss in Angolan children with sickle‐cell disease , 2012, Pediatrics international : official journal of the Japan Pediatric Society.

[17]  Michel Lecendreux,et al.  Iron and attention deficit/hyperactivity disorder: what is the empirical evidence so far? A systematic review of the literature , 2012, Expert review of neurotherapeutics.

[18]  E. Abbas,et al.  Iron deficiency anaemia in children with ADHD , 2012, Archives of Disease in Childhood.

[19]  S. Whiting,et al.  Iron Deficiency Anemia Prevalence at First Stroke or Transient Ischemic Attack , 2012, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[20]  L. Ferrucci,et al.  Association of Skin Color, Race/Ethnicity, and Hearing Loss Among Adults in the USA , 2012, Journal of the Association for Research in Otolaryngology.

[21]  M. Steinberg,et al.  Clinical and Radiologic Findings of Inner Ear Involvement in Sickle Cell Disease , 2011, American Journal of Neuroradiology.

[22]  L. Ferrucci,et al.  Hearing loss prevalence in the United States. , 2011, Archives of internal medicine.

[23]  T. Valdez,et al.  Evaluation of Pediatric Sensorineural Hearing Loss: A Survey of Pediatric Otolaryngologists , 2011, The Annals of otology, rhinology, and laryngology.

[24]  F. Bermejo,et al.  Optimal management of iron deficiency anemia due to poor dietary intake , 2011, International journal of general medicine.

[25]  A. Livne,et al.  Iron deficiency in children with attention deficit hyperactivity disorder. , 2011, The Israel Medical Association journal : IMAJ.

[26]  B. Todorich,et al.  H‐ferritin is the major source of iron for oligodendrocytes , 2011, Glia.

[27]  Jamil A. Shaikh,et al.  Sudden Sensorineural Hearing Loss , 2011, Trends in amplification.

[28]  M. Georgieff,et al.  The role of iron in learning and memory. , 2011, Advances in nutrition.

[29]  M. Zimmermann,et al.  Does obesity increase risk for iron deficiency? A review of the literature and the potential mechanisms. , 2010, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.

[30]  Griffin M. Weber,et al.  Serving the enterprise and beyond with informatics for integrating biology and the bedside (i2b2) , 2010, J. Am. Medical Informatics Assoc..

[31]  H. Bernstein,et al.  Hearing loss in children. , 2009, Pediatrics in review.

[32]  B. Todorich,et al.  Oligodendrocytes and myelination: The role of iron , 2009, Glia.

[33]  J. Pasquini,et al.  Effect of transferrin on hypomyelination induced by iron deficiency , 2008, Journal of neuroscience research.

[34]  Kolade Ernest,et al.  Otological findings among Nigerian children with sickle cell anaemia. , 2008, International journal of pediatric otorhinolaryngology.

[35]  G. Flores,et al.  Secular trends in the prevalence of iron deficiency among US toddlers, 1976-2002. , 2008, Archives of pediatrics & adolescent medicine.

[36]  G. Flores,et al.  Iron Deficiency in Early Childhood in the United States: Risk Factors and Racial/Ethnic Disparities , 2007, Pediatrics.

[37]  J. Millichap,et al.  Serum ferritin in children with attention-deficit hyperactivity disorder. , 2006, Pediatric neurology.

[38]  G. Bertuna,et al.  Sensorineural hearing loss in sickle cell disease patients in Sicily. , 2005, Minerva pediatrica.

[39]  I. Arnulf,et al.  Iron deficiency in children with attention-deficit/hyperactivity disorder. , 2004, Archives of pediatrics & adolescent medicine.

[40]  I. Emodi,et al.  Sensorineural hearing loss in Nigerian children with sickle cell disease. , 2004, International journal of pediatric otorhinolaryngology.

[41]  R. Kleinman,et al.  Pediatric Nutrition Handbook , 2003 .

[42]  Michael K. Georgieff,et al.  Perinatal Iron Deficiency Alters Apical Dendritic Growth in Hippocampal CA1 Pyramidal Neurons , 2003, Developmental Neuroscience.

[43]  J. Beard.  Iron deficiency alters brain development and functioning. , 2003, The Journal of nutrition.

[44]  M. Garrido,et al.  Iron Deficiency Anemia in Infancy: Long-Lasting Effects on Auditory and Visual System Functioning , 2003, Pediatric Research.

[45]  G. Ondzotto,et al.  [Sudden deafness in sickle cell anemia: a case report]. , 2002, Bulletin de la Societe de pathologie exotique.

[46]  H. Ulvi,et al.  Reversal of iron deficiency anemia-induced peripheral neuropathy by iron treatment in children with iron deficiency anemia. , 2002, Journal of tropical pediatrics.

[47]  J. Halterman,et al.  Iron deficiency and cognitive achievement among school-aged children and adolescents in the United States. , 2001, Pediatrics.

[48]  P. Zhao,et al.  Transferrin Is an Essential Factor for Myelination , 1999, Neurochemical Research.

[49]  D. Levy,et al.  Surveillance for waterborne-disease outbreaks--United States, 1995-1996. , 1998, MMWR. CDC surveillance summaries : Morbidity and mortality weekly report. CDC surveillance summaries.

[50]  D. Brody,et al.  Prevalence of hearing loss among children 6 to 19 years of age: the Third National Health and Nutrition Examination Survey. , 1998, JAMA.

[51]  M. Carroll,et al.  Prevalence of iron deficiency in the United States. , 1997, JAMA.

[52]  G. Lescoat,et al.  Iron may induce both DNA synthesis and repair in rat hepatocytes stimulated by EGF/pyruvate. , 1997, Journal of hepatology.

[53]  P. Rudd,et al.  Hearing loss during bacterial meningitis , 1997, Archives of disease in childhood.

[54]  A. Sun,et al.  Changes in the Cochlear Iron Enzymes and Adenosine Triphosphatase in Experimental Iron Deficiency , 1990, The Annals of otology, rhinology, and laryngology.

[55]  A. Adekile,et al.  Sensorineural Hearing Loss in Children with Sickle Cell Anemia , 1987, The Annals of otology, rhinology, and laryngology.

[56]  E. Larkin,et al.  Effect of prenatal iron deficiency on myelination in rat pups. , 1986, The American journal of pathology.

[57]  S. Yehuda,et al.  Long lasting effects of infancy iron deficiency--preliminary results. , 2006, Journal of neural transmission. Supplementum.

[58]  Mu Sun,et al.  Fetal iron deficiency disrupts the maturation of synaptic function and efficacy in area CA1 of the developing rat hippocampus , 2005, Hippocampus.

[59]  D. Zafeiriou,et al.  Hearing loss in children with sickle cell disease. , 2001, Acta oto-rhino-laryngologica Belgica.

[60]  Zheng-min Wang,et al.  Sudden sensorineural hearing loss induced by experimental iron deficiency in rats. , 1992, ORL; journal for oto-rhino-laryngology and its related specialties.

[61]  T. Y. Wang,et al.  Iron deficiency and hearing loss. Experimental study in growing rats. , 1987, ORL; journal for oto-rhino-laryngology and its related specialties.