Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets.
暂无分享,去创建一个
Y. Hannun | A. Koller | L. Obeid | C. Senkal | A. Snider | N. Rana | M. Salama | J. Allopenna | Nadia A. Rana
[1] C. C. Jorgensen,et al. Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2). , 2015, Journal of medicinal chemistry.
[2] Matthias Blüher,et al. Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance. , 2014, Cell metabolism.
[3] L. Berthiaume,et al. Characterization of the interaction of diacylglycerol acyltransferase-2 with the endoplasmic reticulum and lipid droplets. , 2014, Biochimica et biophysica acta.
[4] P. J. McFie,et al. Diacylglycerol Acyltransferase-2 (DGAT2) and Monoacylglycerol Acyltransferase-2 (MGAT2) Interact to Promote Triacylglycerol Synthesis* , 2014, The Journal of Biological Chemistry.
[5] Robert V Farese,et al. Cardiomyocyte-specific Loss of Diacylglycerol Acyltransferase 1 (DGAT1) Reproduces the Abnormalities in Lipids Found in Severe Heart Failure* , 2014, The Journal of Biological Chemistry.
[6] R. Coleman,et al. Acyl-CoA metabolism and partitioning. , 2014, Annual review of nutrition.
[7] A. Futerman,et al. Ceramide synthases as potential targets for therapeutic intervention in human diseases. , 2014, Biochimica et biophysica acta.
[8] A. Stegh,et al. Bcl2L13 is a ceramide synthase inhibitor in glioblastoma , 2014, Proceedings of the National Academy of Sciences.
[9] Ji-Xin Cheng,et al. Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness. , 2014, Cell metabolism.
[10] G. E. Atilla‐Gokcumen,et al. Dividing Cells Regulate Their Lipid Composition and Localization , 2014, Cell.
[11] S. Summers,et al. CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance. , 2014, Cell metabolism.
[12] Baljit Singh,et al. Long Chain Fatty Acyl-CoA Synthetase 4 Is a Biomarker for and Mediator of Hormone Resistance in Human Breast Cancer , 2013, PloS one.
[13] J. Chipuk,et al. BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins. , 2013, The Biochemical journal.
[14] W. Qi,et al. FOXO3 Growth Inhibition of Colonic Cells Is Dependent on Intraepithelial Lipid Droplet Density* , 2013, The Journal of Biological Chemistry.
[15] Robert V Farese,et al. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. , 2013, Developmental cell.
[16] Robert V Farese,et al. Protein Correlation Profiles Identify Lipid Droplet Proteins with High Confidence* , 2013, Molecular & Cellular Proteomics.
[17] Maria Paola Costi,et al. Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity , 2013, Scientific Reports.
[18] J. Olzmann,et al. Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover , 2013, Proceedings of the National Academy of Sciences.
[19] M. Zile,et al. Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes. , 2012, The Journal of clinical investigation.
[20] Y. Peterson,et al. Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy , 2012, Nature chemical biology.
[21] Christer S. Ejsing,et al. A novel pathway of ceramide metabolism in Saccharomyces cerevisiae. , 2012, The Biochemical journal.
[22] Robert V Farese,et al. The FATP1–DGAT2 complex facilitates lipid droplet expansion at the ER–lipid droplet interface , 2012, The Journal of cell biology.
[23] Alan R. Kimmel,et al. Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets , 2012, Journal of Cell Science.
[24] J. Füllekrug,et al. The N-terminal region of acyl-CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake , 2012, Journal of Lipid Research.
[25] A. Merrill,et al. Modulation of Ceramide Synthase Activity via Dimerization* , 2012, The Journal of Biological Chemistry.
[26] Y. Hannun,et al. Ceramide synthases at the centre of sphingolipid metabolism and biology. , 2012, The Biochemical journal.
[27] P. J. McFie,et al. A fluorescent assay to quantitatively measure in vitro acyl CoA:diacylglycerol acyltransferase activity , 2011, Journal of Lipid Research.
[28] Y. Hannun,et al. Many Ceramides* , 2011, The Journal of Biological Chemistry.
[29] Robert V Farese,et al. DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes[S] , 2011, Journal of Lipid Research.
[30] Y. Hannun,et al. Ceramide Synthase-dependent Ceramide Generation and Programmed Cell Death , 2011, The Journal of Biological Chemistry.
[31] D. Mashek,et al. Hepatic long-chain acyl-CoA synthetase 5 mediates fatty acid channeling between anabolic and catabolic pathways[S] , 2010, Journal of Lipid Research.
[32] R. Coleman,et al. Acyl-CoA synthesis, lipid metabolism and lipotoxicity. , 2010, Biochimica et biophysica acta.
[33] L. Obeid,et al. The BCL-2 Protein BAK Is Required for Long-chain Ceramide Generation during Apoptosis* , 2010, The Journal of Biological Chemistry.
[34] Robert V Farese,et al. Lipid Droplets Finally Get a Little R-E-S-P-E-C-T , 2009, Cell.
[35] T. Tsuruo,et al. Acyl‐CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide , 2009, Cancer science.
[36] P. Lu,et al. Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase 3 in colon cancer cells , 2008, Oncogene.
[37] F. Kuypers,et al. Mammalian Long-Chain Acyl-CoA Synthetases , 2008, Experimental biology and medicine.
[38] Yusuf A. Hannun,et al. Principles of bioactive lipid signalling: lessons from sphingolipids , 2008, Nature Reviews Molecular Cell Biology.
[39] D. Maiguel,et al. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genomes⃞s⃞ The online version of this article (available at http://www.jlr.org) contains supplementary data in the form of 3 Tables. Published, JLR Papers in Press, August 30, 2007. , 2007, Journal of Lipid Research.
[40] P. V. Van Veldhoven,et al. (Dihydro)ceramide Synthase 1–Regulated Sensitivity to Cisplatin Is Associated with the Activation of p38 Mitogen-Activated Protein Kinase and Is Abrogated by Sphingosine Kinase 1 , 2007, Molecular Cancer Research.
[41] Robert V Farese,et al. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. , 2007, Cell metabolism.
[42] A. Yamashita,et al. Involvement of ACSL in local synthesis of neutral lipids in cytoplasmic lipid droplets in human hepatocyte HuH7 Published, JLR Papers in Press, March 22, 2007. , 2007, Journal of Lipid Research.
[43] Y. Hannun,et al. Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas , 2007, Molecular Cancer Therapeutics.
[44] Robert V Farese,et al. Membrane Topology and Identification of Key Functional Amino Acid Residues of Murine Acyl-CoA:Diacylglycerol Acyltransferase-2* , 2006, Journal of Biological Chemistry.
[45] U. Landegren,et al. Direct observation of individual endogenous protein complexes in situ by proximity ligation , 2006, Nature Methods.
[46] A. Bielawska,et al. Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. , 2006, Methods.
[47] R. Coleman,et al. Rat Long Chain Acyl-CoA Synthetase 5 Increases Fatty Acid Uptake and Partitioning to Cellular Triacylglycerol in McArdle-RH7777 Cells* , 2006, Journal of Biological Chemistry.
[48] Robert V Farese,et al. A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters Published, JLR Papers in Press, August 16, 2005. DOI 10.1194/jlr.M500168-JLR200 , 2005, Journal of Lipid Research.
[49] Robert V Farese,et al. The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters Published, JLR Papers in Press, April 16, 2005. DOI 10.1194/jlr.M500036-JLR200 , 2005, Journal of Lipid Research.
[50] H. Riezman,et al. Lip1p: a novel subunit of acyl‐CoA ceramide synthase , 2005, The EMBO journal.
[51] L. Shapiro,et al. Proteomic Analysis of Proteins Associated with Lipid Droplets of Basal and Lipolytically Stimulated 3T3-L1 Adipocytes* , 2004, Journal of Biological Chemistry.
[52] Robert V Farese,et al. Lipopenia and Skin Barrier Abnormalities in DGAT2-deficient Mice* , 2004, Journal of Biological Chemistry.
[53] H. Nakagawa,et al. Biosynthesis of acylceramide in murine epidermis: characterization by inhibition of glucosylation and deglucosylation, and by substrate specificity. , 2004, The Journal of investigative dermatology.
[54] Robert V Farese,et al. DGAT1 Is Not Essential for Intestinal Triacylglycerol Absorption or Chylomicron Synthesis* , 2002, The Journal of Biological Chemistry.
[55] Robert V Farese,et al. Cloning of DGAT2, a Second Mammalian Diacylglycerol Acyltransferase, and Related Family Members* , 2001, The Journal of Biological Chemistry.
[56] Y. Kishimoto,et al. In vivo metabolism of ceramides in rat brain. Fatty acid replacement and esterification of ceramide. , 1977, The Journal of biological chemistry.