Allosteric inhibition of protein tyrosine phosphatase 1B

[1]  D. Lawrence,et al.  Cellular effects of small molecule PTP1B inhibitors on insulin signaling. , 2003, Biochemistry.

[2]  S. Teague.  Implications of protein flexibility for drug discovery , 2003, Nature Reviews Drug Discovery.

[3]  Daniel A Erlanson,et al.  Discovery of a new phosphotyrosine mimetic for PTP1B using breakaway tethering. , 2003, Journal of the American Chemical Society.

[4]  David H. Williams,et al.  Latest developments in crystallography and structure-based design of protein kinase inhibitors as drug candidates. , 2002, Current opinion in pharmacology.

[5]  J. Ermolieff,et al.  Protein tyrosine phosphatase 1B inhibitors for diabetes , 2002, Nature Reviews Drug Discovery.

[6]  J. Waring,et al.  PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[7]  J. Waring,et al.  Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis. , 2002, Diabetes.

[8]  L. Tong,et al.  Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site , 2002, Nature Structural Biology.

[9]  A. Christopoulos.  Allosteric binding sites on cell-surface receptors: novel targets for drug discovery , 2002, Nature Reviews Drug Discovery.

[10]  P G Drake,et al.  Structural and Evolutionary Relationships among Protein Tyrosine Phosphatase Domains , 2001, Molecular and Cellular Biology.

[11]  X Y Wang,et al.  Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action. , 2001, Biochemistry.

[12]  A. Saltiel.  New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes , 2001, Cell.

[13]  D. Barford,et al.  Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B. , 2000, Molecular cell.

[14]  E. Freire,et al.  Can allosteric regulation be predicted from structure? , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[15]  P. Seeburg,et al.  Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. , 2000, Science.

[16]  J. Chernoff,et al.  Down-regulation of Insulin Signaling by Protein-tyrosine Phosphatase 1B Is Mediated by an N-terminal Binding Region* , 2000, The Journal of Biological Chemistry.

[17]  Young-Bum Kim,et al.  Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice , 2000, Molecular and Cellular Biology.

[18]  Ole Hvilsted Olsen,et al.  Structure-based Design of a Low Molecular Weight, Nonphosphorus, Nonpeptide, and Highly Selective Inhibitor of Protein-tyrosine Phosphatase 1B* , 2000, The Journal of Biological Chemistry.

[19]  L. Iversen,et al.  2-(Oxalylamino)-Benzoic Acid Is a General, Competitive Inhibitor of Protein-tyrosine Phosphatases* , 2000, The Journal of Biological Chemistry.

[20]  J. Pflugrath,et al.  The finer things in X-ray diffraction data collection. , 1999, Acta crystallographica. Section D, Biological crystallography.

[21]  C. Moxham,et al.  PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes. , 1999, Journal of medicinal chemistry.

[22]  H. Nam,et al.  Crystal Structure of the Tandem Phosphatase Domains of RPTP LAR , 1999, Cell.

[23]  B. Kennedy,et al.  Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. , 1999, Science.

[24]  D. Barford,et al.  Visualization of the Cysteinyl-phosphate Intermediate of a Protein-tyrosine Phosphatase by X-ray Crystallography* , 1998, The Journal of Biological Chemistry.

[25]  D S Lawrence,et al.  Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[26]  N. Tonks,et al.  The Noncatalytic C-terminal Segment of the T Cell Protein Tyrosine Phosphatase Regulates Activity via an Intramolecular Mechanism* , 1997, The Journal of Biological Chemistry.

[27]  M. Quon,et al.  Protein-tyrosine Phosphatases PTP1B and Syp Are Modulators of Insulin-stimulated Translocation of GLUT4 in Transfected Rat Adipose Cells* , 1997, The Journal of Biological Chemistry.

[28]  D. Hill,et al.  Direct Binding of the Proline-rich Region of Protein Tyrosine Phosphatase 1B to the Src Homology 3 Domain of p130Cas* , 1996, The Journal of Biological Chemistry.

[29]  J. Olefsky,et al.  Protein Tyrosine Phosphatase 1B Interacts With the Activated Insulin Receptor , 1996, Diabetes.

[30]  Jerrold M. Olefsky,et al.  Protein-tyrosine Phosphatase 1B Is a Negative Regulator of Insulin- and Insulin-like Growth Factor-I-stimulated Signaling* , 1996, The Journal of Biological Chemistry.

[31]  J. Dixon,et al.  Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[32]  J. Meyerovitch,et al.  Osmotic Loading of Neutralizing Antibodies Demonstrates a Role for Protein-tyrosine Phosphatase 1B in Negative Regulation of the Insulin Action Pathway (*) , 1995, The Journal of Biological Chemistry.

[33]  D. Barford,et al.  Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B. , 1995, Science.

[34]  Collaborative Computational,et al.  The CCP4 suite: programs for protein crystallography. , 1994, Acta crystallographica. Section D, Biological crystallography.

[35]  D. Barford,et al.  Crystal structure of human protein tyrosine phosphatase 1B. , 1994, Science.

[36]  B. Franza,et al.  Multi‐site phosphorylation of the protein tyrosine phosphatase, PTP1B: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylation. , 1993, The EMBO journal.

[37]  J. Zou,et al.  Improved methods for building protein models in electron density maps and the location of errors in these models. , 1991, Acta crystallographica. Section A, Foundations of crystallography.

[38]  H. Saito,et al.  Distinct functional roles of the two intracellular phosphatase like domains of the receptor‐linked protein tyrosine phosphatases LCA and LAR. , 1990, The EMBO journal.

[39]  I. Luque,et al.  Structural stability of binding sites: Consequences for binding affinity and allosteric effects , 2000, Proteins.