Morphological characterization of bioerodible polymers. 3. Characterization of the erosion and intact zones in polyanhydrides using scanning electron microscopy

The morphological changes which occur during the preparation and degradation of polyanhydrides derived from sebacic acid (SA), 1,3-bis(p-carboxyphenoxy)propane (CPP), 1,6-bis(p-carboxyphenoxy)hexane (CPH), (carboxyphenoxy)methane (CPM) and 5-(p-carboxyphenoxy)-valeric acid (CPV) are described by SEM. Amorphous and semicrystalline polymers fabricated by melt-casting displayed well-defined eroding zones with specific spherulitic or lamellar structures typical for each copolymer composition