Comparison of human and canine external femoral morphologies in the context of total hip replacement.

The canine is frequently used as a model for human hip arthroplasty research. In order to better understand the appropriateness of the canine as a model for human total hip replacement studies, the external morphology of canine and human femurs were examined and compared. Several differences were found between canine and human femora, including angular measurements, anterior bow, and femoral head position relative to the femoral diaphysis. In addition, the human femur was noted to undergo age-related changes in several of the measured parameters. The canine femur did not exhibit any age-related changes in the measured parameters. This study suggests that there are limitations to the use of the canine model in human hip arthroplasty research, and that discretion must be exercised when attempting to extrapolate results from a canine study to the human clinical condition.

[1]  C. Ruff.  Allometry between length and cross-sectional dimensions of the femur and tibia in Homo sapiens sapiens. , 1984, American journal of physical anthropology.

[2]  D. Ilstrup,et al.  Total hip arthroplasty. , 1978, The Journal of bone and joint surgery. American volume.

[3]  M. Freeman,et al.  The relationship of neck orientation to the shape of the proximal femur. , 1987, The Journal of arthroplasty.

[4]  K. Ogata,et al.  A simple biplanar method of measuring femoral anteversion and neck-shaft angle. , 1979, The Journal of bone and joint surgery. American volume.

[5]  W H Harris,et al.  Proximal strain distribution in the loaded femur. An in vitro comparison of the distributions in the intact femur and after insertion of different hip-replacement femoral components. , 1978, The Journal of bone and joint surgery. American volume.

[6]  W H Harris,et al.  Bone ingrowth into porous coated canine acetabular replacements: the effect of pore size, apposition, and dislocation. , 1985, The Hip.

[7]  M. Panjabi,et al.  Selection of an animal model for implant fixation studies: anatomical aspects. , 1982, The Yale journal of biology and medicine.

[8]  R. B. Hohn,et al.  Inclination and Anteversion Angles of the Femoral Head and Neck in the Dog Evaluation of a Standard Method of Measurement , 1985 .

[9]  V. T. Inman.  Functional aspects of the abductor muscles of the hip. , 1947, The Journal of bone and joint surgery. American volume.

[10]  D. R. Sumner,et al.  The geometry of the adult canine proximal femur , 1990, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[11]  J. Galante,et al.  A comparative study of porous coatings in a weight-bearing total hip-arthroplasty model. , 1986, The Journal of bone and joint surgery. American volume.

[12]  R Vanderby,et al.  Canine intersegmental hip joint forces and moments before and after cemented total hip replacement. , 1991, Journal of biomechanics.

[13]  K. Heiple,et al.  Structural properties of immature canine bone. , 1981, Journal of biomechanical engineering.

[14]  N. Rydell.  Forces acting on the femoral head-prosthesis. A study on strain gauge supplied prostheses in living persons. , 1966, Acta orthopaedica Scandinavica.

[15]  W. Hayes,et al.  Sex differences in age‐related remodeling of the femur and tibia , 1988, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[16]  R. Martin,et al.  Age and sex-related changes in the structure and strength of the human femoral shaft. , 1977, Journal of biomechanics.

[17]  H. Tullos,et al.  The anatomic basis of femoral component design. , 1988, Clinical orthopaedics and related research.

[18]  T B Belytschko,et al.  A stress analysis of the femoral stem in total hip prostheses. , 1976, The Journal of bone and joint surgery. American volume.

[19]  J. Galante,et al.  Determinants of stress shielding: design versus materials versus interface. , 1992, Clinical orthopaedics and related research.

[20]  K E Marks,et al.  A ten-year follow-up of one hundred consecutive Müller curved-stem total hip-replacement arthroplasties. , 1982, The Journal of bone and joint surgery. American volume.

[21]  Friedrich Pauwels,et al.  Biomechanics of the Normal and Diseased Hip , 1976 .

[22]  D R Sumner,et al.  Remodeling and ingrowth of bone at two years in a canine cementless total hip-arthroplasty model. , 1992, The Journal of bone and joint surgery. American volume.

[23]  R. D. McLeish,et al.  Abduction forces in the one-legged stance. , 1970, Journal of biomechanics.

[24]  R. N. Stauffer.  Ten-year follow-up study of total hip replacement. , 1982, The Journal of bone and joint surgery. American volume.

[25]  J. Szivek,et al.  The effect of proximally and fully porous‐coated canine hip stem design on bone modeling , 1987, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[26]  F. P. Magee,et al.  A canine composite femoral stem. An in vivo study. , 1988, Clinical orthopaedics and related research.

[27]  B M Persson.  Synovial osteochondromatosis of the hip. (Report of 8 cases including 2 in brothers). , 1966, Acta orthopaedica Scandinavica.

[28]  Christopher B. Ruff,et al.  STRUCTURAL CHANGES IN THE LOWER LIMB BONES WITH AGING AT PECOS PUEBLO , 1981 .

[29]  R. Smith,et al.  Epiphysial fusion in the greyhound. , 1960 .

[30]  E. Radin,et al.  Biomechanics of the human hip. , 1980, Clinical orthopaedics and related research.

[31]  P. Maquet.  Biomechanics of the Hip: As Applied to Osteoarthritis and Related Conditions , 1984 .

[32]  J. Charnley,et al.  Radiological demarcation of cemented sockets in total hip replacement. , 1976, Clinical orthopaedics and related research.

[33]  M. Larson,et al.  Femoral expansion in total hip arthroplasty. , 1987, The Journal of arthroplasty.

[34]  Engh Ca,et al.  The influence of stem size and extent of porous coating on femoral bone resorption after primary cementless hip arthroplasty. , 1988 .

[35]  P. Ring,et al.  Osteolytic changes in the upper femoral shaft following porous-coated hip replacement. , 1985, The Journal of bone and joint surgery. British volume.

[36]  W. Harris,et al.  Alterations in femoral and acetabular bone strains immediately following cementless total hip arthroplasty: An in vitro canine study , 1991, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[37]  W C Hayes,et al.  Subperiosteal expansion and cortical remodeling of the human femur and tibia with aging. , 1982, Science.

[38]  A Rohlmann,et al.  A comparison of hip joint forces in sheep, dog and man. , 1984, Journal of biomechanics.

[39]  M. F. Ericksen.  Aging changes in the medullary cavity of the proximal femur in American Blacks and Whites. , 1979, American journal of physical anthropology.

[40]  N. A. Walensky.  A study of anterior femoral curvature in man , 1965, The Anatomical record.

[41]  I. Clarke,et al.  Porous ingrowth fixation of the femoral component in a canine surface replacement of the hip. , 1982, Clinical orthopaedics and related research.

[42]  A. U. Daniels,et al.  Endosteal bone loss after total hip arthroplasty. , 1989, Clinical orthopaedics and related research.

[43]  R. Huiskes,et al.  The relationship between stress shielding and bone resorption around total hip stems and the effects of flexible materials. , 1992, Clinical orthopaedics and related research.

[44]  H. Amstutz,et al.  "Modes of failure" of cemented stem-type femoral components: a radiographic analysis of loosening. , 1979, Clinical orthopaedics and related research.

[45]  R. Smith.  Radiological Observations on the Limbs of Young Greyhounds , 1960 .

[46]  W H Harris,et al.  Extensive localized bone resorption in the femur following total hip replacement. , 1976, The Journal of bone and joint surgery. American volume.

[47]  E. Rybicki,et al.  On the mathematical analysis of stress in the human femur. , 1972, Journal of biomechanics.

[48]  E. Simmons,et al.  Age‐related changes in the human femoral cortex , 1991, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[49]  J. G. Andrews,et al.  A biomechanical investigation of the human hip. , 1978, Journal of biomechanics.

[50]  P. Leyvraz,et al.  The morphology of the proximal femur. A three-dimensional radiographic analysis. , 1992, The Journal of bone and joint surgery. British volume.

[51]  C. Engh,et al.  Porous-coated hip replacement. The factors governing bone ingrowth, stress shielding, and clinical results. , 1987, The Journal of bone and joint surgery. British volume.

[52]  Richmond W. Smith,et al.  Femoral Expansion in Aging Women: Implications for Osteoporosis and Fractures , 1964, Science.