A mechanism for action of oscillating electric fields on cells.

The biological effects of electromagnetic fields have seriously concerned the scientific community and the public as well in the past decades as more and more evidence has accumulated about the hazardous consequences of so-called "electromagnetic pollution." This theoretical model is based on the simple hypothesis that an oscillating external electric field will exert an oscillating force to each of the free ions that exist on both sides of all plasma membranes and that can move across the membranes through transmembrane proteins. This external oscillating force will cause a forced vibration of each free ion. When the amplitude of the ions' forced vibration transcends some critical value, the oscillating ions can give a false signal for opening or closing channels that are voltage gated (or even mechanically gated), in this way disordering the electrochemical balance of the plasma membrane and consequently the whole cell function.

[1]  J. Swez,et al.  A mechanism for action of extremely low frequency electromagnetic fields on biological systems. , 1996, Biochemical and biophysical research communications.

[2]  Y. Jan,et al.  Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence , 1991, Nature.

[3]  Y. Jan,et al.  Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila. , 1987, Science.

[4]  A. Hodgkin,et al.  A quantitative description of membrane current and its application to conduction and excitation in nerve , 1952, The Journal of physiology.

[5]  M. Berridge Inositol trisphosphate‐induced membrane potential oscillations in Xenopus oocytes. , 1988, The Journal of physiology.

[6]  R. Adair Biological effects on the cellular level of electric field pulses. , 1991, Health Physics.

[7]  B. Hille Ionic channels of excitable membranes , 2001 .

[8]  J. Davies,et al.  Molecular Biology of the Cell , 1983, Bristol Medico-Chirurgical Journal.

[9]  F. Conti,et al.  Structural parts involved in activation and inactivation of the sodium channel , 1989, Nature.

[10]  E. Liman,et al.  Voltage-sensing residues in the S4 region of a mammalian K+ channel , 1991, Nature.

[11]  M. T. Marron,et al.  Effects of electromagnetic fields on molecules and cells. , 1995, International review of cytology.

[12]  M Feychting,et al.  Magnetic Fields, Leukemia, and Central Nervous System Tumors in Swedish Adults Residing near High‐Voltage Power Lines , 1994, Epidemiology.

[13]  M Feychting,et al.  Magnetic fields and cancer in children residing near Swedish high-voltage power lines. , 1993, American journal of epidemiology.

[14]  Y. Tsunoda Cytosolic free calcium spiking affected by intracellular pH change. , 1990, Experimental cell research.

[15]  A. Hodgkin,et al.  The effects of changes in internal ionic concentrations on the electrical properties of perfused giant axons , 1962, The Journal of physiology.

[16]  V. Flockerzi,et al.  Primary structure of the receptor for calcium channel blockers from skeletal muscle , 1987, Nature.

[17]  G. Poste,et al.  New Insights into Cell and Membrane Transport Processes , 1986, New Horizons in Therapeutics.

[18]  H. Sullivan Ionic Channels of Excitable Membranes, 2nd Ed. , 1992, Neurology.

[19]  Charles Polk,et al.  CRC Handbook of Biological Effects of Electromagnetic Fields , 1986 .

[20]  B. Honig,et al.  Electrostatic interactions in membranes and proteins. , 1986, Annual review of biophysics and biophysical chemistry.

[21]  J. Tytgat,et al.  Pursuing the voltage sensor of a voltage-gated mammalian potassium channel. , 1993, The Journal of biological chemistry.

[22]  M. Berridge,et al.  Cytosolic calcium oscillators , 1988, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[23]  M. Coleman,et al.  Leukaemia and residence near electricity transmission equipment: a case-control study. , 1989, British Journal of Cancer.

[24]  H. Wachtel,et al.  Case-control study of childhood cancer and exposure to 60-Hz magnetic fields. , 1988, American journal of epidemiology.

[25]  B. Sakmann,et al.  The patch clamp technique. , 1992, Scientific American.

[26]  R. Kavet,et al.  Can low-level 50/60 Hz electric and magnetic fields cause biological effects? , 1997, Radiation research.

[27]  Elizabeth Corcoran,et al.  Tacky Lasers are the Tiniest yet , 1992 .

[28]  H. Takeshima,et al.  Existence of distinct sodium channel messenger RNAs in rat brain , 1986, Nature.

[29]  P. Gray Oscillations of free cytosolic calcium evoked by cholinergic and catecholaminergic agonists in rat parotid acinar cells. , 1988, The Journal of physiology.

[30]  F. Abboud,et al.  Non-voltage-gated Ca2+ influx through mechanosensitive ion channels in aortic baroreceptor neurons. , 1997, Circulation research.

[31]  Francisco Bezanilla,et al.  Gating currents associated with potassium channel activation , 1982, Nature.

[32]  N. Wertheimer,et al.  Electrical wiring configurations and childhood cancer. , 1979, American journal of epidemiology.