A Conceptual Modeling Approach To Improve Human Genome Understanding

[1]  Michelle McKinney,et al.  Human Genome Project Information , 2012 .

[2]  Oscar Pastor,et al.  Enforcing Conceptual Modeling to improve the understanding of human genome , 2010, 2010 Fourth International Conference on Research Challenges in Information Science (RCIS).

[3]  H. Kroemer,et al.  A Piece in the Puzzle of Personalized Medicine , 2010, Clinical pharmacology and therapeutics.

[4]  Oscar Pastor,et al.  Conceptual Modeling of Human Genome Mutations - A Dichotomy Between what we Have and What we Should Have , 2010, BIOINFORMATICS.

[5]  Tyrone D. Cannon,et al.  Phenomics: the systematic study of phenotypes on a genome-wide scale , 2009, Neuroscience.

[6]  F. Collins,et al.  Potential etiologic and functional implications of genome-wide association loci for human diseases and traits , 2009, Proceedings of the National Academy of Sciences.

[7]  P. Visscher,et al.  On Jim Watson's APOE status: genetic information is hard to hide , 2009, European Journal of Human Genetics.

[8]  P. Stenson,et al.  The Human Gene Mutation Database: 2008 update , 2009, Genome Medicine.

[9]  Olli Simell,et al.  Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes , 2008, The Journal of experimental medicine.

[10]  A. Valleron,et al.  Causes of early-onset type 1 diabetes: toward data-driven environmental approaches , 2008, The Journal of experimental medicine.

[11]  S. Hess,et al.  Adipose proteome analysis: focus on mediators of insulin resistance , 2008, Expert review of proteomics.

[12]  J. Trent,et al.  Using biointelligence to search the cancer genome: an epistemological perspective on knowledge recovery strategies to enable precision medical genomics , 2008, Oncogene.

[13]  P. Froguel,et al.  Is obesity our genetic legacy? , 2008, The Journal of clinical endocrinology and metabolism.

[14]  Christian Gieger,et al.  Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum , 2008, PLoS genetics.

[15]  G. Canfora,et al.  Frontiers of reverse engineering: A conceptual model , 2008, 2008 Frontiers of Software Maintenance.

[16]  C. Napoli,et al.  New insights into cardiovascular and lipid metabolomics , 2008, Journal of cellular biochemistry.

[17]  Amy E. Hawkins,et al.  DNA sequencing of a cytogenetically normal acute myeloid leukemia genome , 2008, Nature.

[18]  Melanie Y. White,et al.  The Role of Proteomics in Clinical Cardiovascular Biomarker Discovery* , 2008, Molecular & Cellular Proteomics.

[19]  Daniel Bayer,et al.  SNPtoGO: characterizing SNPs by enriched GO terms , 2008, Bioinform..

[20]  Carola Eschenbach,et al.  Formal Ontology in Information Systems , 2008 .

[21]  Zhaohui S. Qin,et al.  A second generation human haplotype map of over 3.1 million SNPs , 2007, Nature.

[22]  Andrew G. Clark,et al.  The HapMap project , 2007 .

[23]  T. Frayling.  Genome–wide association studies provide new insights into type 2 diabetes aetiology , 2007, Nature Reviews Genetics.

[24]  William Stafford Noble,et al.  Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project , 2007, Nature.

[25]  M. Gerstein,et al.  What is a gene, post-ENCODE? History and updated definition. , 2007, Genome research.

[26]  Jun Zhu,et al.  Increasing the Power to Detect Causal Associations by Combining Genotypic and Expression Data in Segregating Populations , 2007, PLoS Comput. Biol..

[27]  Marko Sysi-Aho,et al.  Acquired Obesity Is Associated with Changes in the Serum Lipidomic Profile Independent of Genetic Effects – A Monozygotic Twin Study , 2007, PloS one.

[28]  Frederico T. Fonseca,et al.  Learning The Differences Between Ontologies and Conceptual Schemas Through Ontology-Driven Information Systems , 2007, J. Assoc. Inf. Syst..

[29]  Tatiana A. Tatusova,et al.  Entrez Gene: gene-centered information at NCBI , 2004, Nucleic Acids Res..

[30]  Mario Piattini,et al.  Ontologies for Software Engineering and Software Technology , 2010 .

[31]  Chi Pui Pang,et al.  HTRA1 promoter polymorphism in wet age-related macular degeneration. , 2007, Science.

[32]  H. Dressman,et al.  Genomic signatures to guide the use of chemotherapeutics , 2006, Nature Medicine.

[33]  Hsinchun Chen,et al.  A framework of integrating gene relations from heterogeneous data sources: an experiment on Arabidopsis thaliana , 2006, Bioinform..

[34]  Amedeo Napoli,et al.  SNP-Converter: An Ontology-Based Solution to Reconcile Heterogeneous SNP Descriptions for Pharmacogenomic Studies , 2006, DILS.

[35]  M. Orešič,et al.  Metabolomic approaches to phenotype characterization and applications to complex diseases , 2006, Expert review of molecular diagnostics.

[36]  Helen Pearson,et al.  Genetics: What is a gene? , 2006, Nature.

[37]  Gerd Wagner,et al.  Ontologies, Meta-models, and the Model-Driven Paradigm , 2006, Ontologies for Software Engineering and Software Technology.

[38]  R. Flavell,et al.  Interchromosomal associations between alternatively expressed loci , 2005, Nature.

[39]  Evelyn Camon,et al.  The EMBL Nucleotide Sequence Database , 2000, Nucleic Acids Res..

[40]  M. Olivier.  A haplotype map of the human genome. , 2003, Nature.

[41]  M. Olivier.  A haplotype map of the human genome , 2003, Nature.

[42]  Paul T. Groth,et al.  The ENCODE (ENCyclopedia Of DNA Elements) Project , 2004, Science.

[43]  D. Nebert,et al.  Advances in pharmacogenomics and individualized drug therapy: exciting challenges that lie ahead. , 2004, European journal of pharmacology.

[44]  Ben van Ommen,et al.  Nutrigenomics: exploiting systems biology in the nutrition and health arenas. , 2004, Nutrition.

[45]  B. van Ommen.  Nutrigenomics: exploiting systems biology in the nutrition and health arenas. , 2004, Nutrition.

[46]  Toshihiro Tanaka.  The International HapMap Project , 2003, Nature.

[47]  Russ B. Altman,et al.  MutDB: annotating human variation with functionally relevant data , 2003, Bioinform..

[48]  Zhongming Zhao,et al.  Investigating single nucleotide polymorphism (SNP) density in the human genome and its implications for molecular evolution. , 2003, Gene.

[49]  C. Sabatti,et al.  The Human Phenome Project , 2003, Nature Genetics.

[50]  F. Collins,et al.  A vision for the future of genomics research , 2003, Nature.

[51]  F. Collins,et al.  The Human Genome Project: Lessons from Large-Scale Biology , 2003, Science.

[52]  A. Vignal,et al.  A review on SNP and other types of molecular markers and their use in animal genetics , 2002, Genetics Selection Evolution.

[53]  Pedro de Atauri,et al.  Metabolic control analysis in drug discovery and disease , 2002, Nature Biotechnology.

[54]  Mathew W. Wright,et al.  The HUGO Gene Nomenclature Committee (HGNC) , 2001, Human Genetics.

[55]  D. Kell,et al.  A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations , 2001, Nature Biotechnology.

[56]  Csilla Szabo,et al.  The Breast Cancer Information Core: Database design, structure, and scope , 2000, Human mutation.

[57]  Carole A. Goble,et al.  Conceptual modelling of genomic information , 2000, Bioinform..

[58]  M. Ashburner,et al.  Gene Ontology: tool for the unification of biology , 2000, Nature Genetics.

[59]  강문설.  [서평]「The Unified Modeling Language User Guide」 , 1999 .

[60]  Ivar Jacobson,et al.  The Unified Modeling Language User Guide , 1998, J. Database Manag..

[61]  Alain Viari,et al.  Imagene: an integrated computer environment for sequence annotation and analysis , 1999, Bioinform..

[62]  Michael Krawczak,et al.  The human gene mutation database , 1998, Nucleic Acids Res..

[63]  Nari Na.  Glossary of genetic terms. , 1998, AACN clinical issues.

[64]  Takuro Tamura,et al.  Formal design and implementation of an improved DDBJ DNA database with a new schema and object-oriented library , 1998, Bioinform..

[65]  N. Risch,et al.  A comparison of linkage disequilibrium measures for fine-scale mapping. , 1995, Genomics.

[66]  I-Min A. Chen,et al.  Modeling scientific experiments with an object data model , 1995, Proceedings of the Eleventh International Conference on Data Engineering.

[67]  Thomas R. Gruber,et al.  A translation approach to portable ontology specifications , 1993, Knowl. Acquis..

[68]  James H. Cross,et al.  Reverse engineering and design recovery: a taxonomy , 1990, IEEE Software.

[69]  M. Mann,et al.  Electrospray ionization for mass spectrometry of large biomolecules. , 1989, Science.

[70]  D. Mccormick.  Sequence the Human Genome , 1986, Bio/Technology.

[71]  Alexander Borgida,et al.  Conceptual Modeling of Information Systems , 1985, On Knowledge Base Management Systems.