Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes

[1]  M. Bloch,et al.  The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis , 2011, Neuropsychopharmacology.

[2]  B. Binder,et al.  Constant Darkness Induces IL-6-Dependent Depression-Like Behavior through the NF-κB Signaling Pathway , 2011, The Journal of Neuroscience.

[3]  F. Sinner,et al.  Prolonged Depression-Like Behavior Caused by Immune Challenge: Influence of Mouse Strain and Social Environment , 2011, PloS one.

[4]  C. Putterman,et al.  The MRL/lpr Mouse Strain as a Model for Neuropsychiatric Systemic Lupus Erythematosus , 2011, Journal of biomedicine & biotechnology.

[5]  R. Dantzer,et al.  Central Administration of Lipopolysaccharide Induces Depressive-like Behavior in Vivo and Activates Brain Indoleamine 2,3 Dioxygenase In Murine Organotypic Hippocampal Slice Cultures , 2010, Journal of Neuroinflammation.

[6]  H. Anisman,et al.  Behavioral Neuroscience , 2022 .

[7]  Hui-Ming Lin,et al.  The effect of chronic mild stress on tumor-bearing rats’ behavior and its mechanism , 2010, Neuroscience Letters.

[8]  B. Morasco,et al.  Neuroimmune mechanisms of cytokine-induced depression: Current theories and novel treatment strategies , 2010, Neurobiology of Disease.

[9]  N. Herrmann,et al.  A Meta-Analysis of Cytokines in Major Depression , 2010, Biological Psychiatry.

[10]  W. Young,et al.  Housing conditions and stimulus females: a robust social discrimination task for studying male rodent social recognition , 2009, Nature Protocols.

[11]  Martin Samuelsson,et al.  Interleukin-6 Is Elevated in the Cerebrospinal Fluid of Suicide Attempters and Related to Symptom Severity , 2009, Biological Psychiatry.

[12]  R. Yoshimura,et al.  Higher plasma interleukin-6 (IL-6) level is associated with SSRI- or SNRI-refractory depression , 2009, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[13]  C. Putterman,et al.  Depression is an early disease manifestation in lupus-prone MRL/lpr mice , 2009, Journal of Neuroimmunology.

[14]  J. Suls,et al.  Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis , 2009, Psychosomatic medicine.

[15]  Chih-Hung Lin,et al.  IL-6 mediated alterations on immobile behavior of rats in the forced swim test via ERK1/2 activation in specific brain regions , 2008, Behavioural Brain Research.

[16]  H. Anisman,et al.  Lipopolysaccharide and a social stressor influence behaviour, corticosterone and cytokine levels: Divergent actions in cyclooxygenase-2 deficient mice and wild type controls , 2008, Journal of Neuroimmunology.

[17]  M. H. Pollack,et al.  A detailed examination of cytokine abnormalities in Major Depressive Disorder , 2008, European Neuropsychopharmacology.

[18]  J. Koo,et al.  IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress , 2008, Proceedings of the National Academy of Sciences.

[19]  Maurizio Fava,et al.  The STAR*D project results: A comprehensive review of findings , 2007, Current psychiatry reports.

[20]  Y. Shoenfeld,et al.  Behavioral changes in systemic lupus erythematosus are of an autoimmune nature , 2007, Nature Clinical Practice Rheumatology.

[21]  Yong-Ku Kim,et al.  Cytokine imbalance in the pathophysiology of major depressive disorder , 2007, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[22]  P. Scully,et al.  Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy. , 2007, Journal of psychiatric research.

[23]  J. Sánchez-Guerrero,et al.  Interleukin-6 and chemokines in the neuropsychiatric manifestations of systemic lupus erythematosus. , 2007, Arthritis and rheumatism.

[24]  R. Dantzer,et al.  Named Series: Twenty Years of Brain, Behavior, and Immunity Twenty years of research on cytokine-induced sickness behavior , 2007 .

[25]  A. Ehlis,et al.  Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression , 2007, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

[26]  A. Siracusano,et al.  Association between enhanced soluble CD40 ligand and proinflammatory and prothrombotic states in major depressive disorder: pilot observations on the effects of selective serotonin reuptake inhibitor therapy. , 2006, The Journal of clinical psychiatry.

[27]  P. Gass,et al.  IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors , 2006, Neurobiology of Disease.

[28]  R. Ring,et al.  Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications , 2006, Psychopharmacology.

[29]  E. Göka,et al.  IL‐6 levels decrease with SSRI treatment in patients with major depression , 2005, Human psychopharmacology.

[30]  M. Wichers,et al.  Cytokines and major depression , 2005, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[31]  J. Cryan,et al.  In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice , 2004, Molecular Psychiatry.

[32]  R. Dantzer,et al.  Cytokine-induced sickness behavior , 2003, Brain, Behavior, and Immunity.

[33]  E. Zorrilla,et al.  The Relationship of Depression and Stressors to Immunological Assays: A Meta-Analytic Review , 2001, Brain, Behavior, and Immunity.

[34]  T. Santoro,et al.  Aberrant cytokine gene expression in the hippocampus in murine systemic lupus erythematosus , 2001, Neuroscience Letters.

[35]  R. Dantzer.  Cytokine‐Induced Sickness Behavior: Mechanisms and Implications , 2001, Annals of the New York Academy of Sciences.

[36]  H. Anisman,et al.  Synergistic Effects of Interleukin-1β, Interleukin-6, and Tumor Necrosis Factor-α: Central Monoamine, Corticosterone, and Behavioral Variations , 2000, Neuropsychopharmacology.

[37]  R. Dantzer,et al.  Central administration of rat IL-6 induces HPA activation and fever but not sickness behavior in rats. , 1999, American journal of physiology. Regulatory, integrative and comparative physiology.

[38]  T. Komori,et al.  The expressions of mRNAs for interleukin-6 (IL-6) and the IL-6 receptor (IL-6R) in the rat hypothalamus and midbrain during restraint stress. , 1998, Life sciences.

[39]  H. Anisman,et al.  An assessment of the effects of central interleukin-1β, -2, -6, and tumor necrosis factor-α administration on some behavioural, neurochemical, endocrine and immune parameters in the rat , 1998, Neuroscience.

[40]  J. Denburg,et al.  Reduced Preference for Sucrose in Autoimmune Mice: A Possible Role of Interleukin-6 , 1997, Brain Research Bulletin.

[41]  E. Bosmans,et al.  Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression. , 1997, Cytokine.

[42]  T. Komori,et al.  The influence of restraint stress on the expression of mRNAs for IL-6 and the IL-6 receptor in the hypothalamus and midbrain of the rat. , 1997, Life sciences.

[43]  J. Rybakowski,et al.  Interleukin‐6 Serum Levels in Depressed Patients before and after Treatment with Fluoxetine , 1995, Annals of the New York Academy of Sciences.

[44]  R. Dantzer,et al.  Pyrogens Specifically Disrupt the Acquisition of a Task Involving Cognitive Processing in the Rat , 1995, Brain, Behavior, and Immunity.

[45]  C. Tsai,et al.  Abnormal Splenic and Thymic IL‐4 and TNF‐α Expression in MRL‐lpr/lpr Mice , 1995, Scandinavian journal of immunology.

[46]  Michael Maes,et al.  Evidence for an immune response in major depression: A review and hypothesis , 1995, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[47]  L. D. Ward,et al.  High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130. , 1994, The Journal of biological chemistry.

[48]  H. Anisman,et al.  Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6 , 1994, Brain Research.

[49]  M. Oitzl,et al.  Interleukin-1β, but not interleukin-6, impairs spatial navigation learning , 1993, Brain Research.

[50]  J. Rabe-Jabłońska,et al.  [Affective disorders in the fourth edition of the classification of mental disorders prepared by the American Psychiatric Association -- diagnostic and statistical manual of mental disorders]. , 1993, Psychiatria polska.

[51]  S. Nagata,et al.  Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[52]  R. Dantzer,et al.  Effects of lipopolysaccharide on food-motivated behavior in the rat are not blocked by an interleukin-1 receptor antagonist , 1992, Neuroscience Letters.

[53]  R. Dantzer,et al.  Cytokines and Sickness Behavior , 1998, Annals of the New York Academy of Sciences.

[54]  R. S. Smith.  The macrophage theory of depression. , 1991, Medical hypotheses.

[55]  A. Vander,et al.  The effects of psychological stress on plasma interleukin-6 activity in rats , 1990, Physiology & Behavior.

[56]  B. Hart.  Biological basis of the behavior of sick animals , 1988, Neuroscience & Biobehavioral Reviews.

[57]  A. Theofilopoulos,et al.  Etiology and pathogenesis of a spontaneous lupus-like syndrome in mice. , 1978, Arthritis and rheumatism.

[58]  R. Dantzer,et al.  From inflammation to sickness and depression: when the immune system subjugates the brain , 2008, Nature Reviews Neuroscience.

[59]  D. Kupfer,et al.  Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. , 2006, The American journal of psychiatry.

[60]  Andrew H. Miller,et al.  Cytokines sing the blues: inflammation and the pathogenesis of depression. , 2006, Trends in immunology.

[61]  Andrew H. Miller,et al.  Neuropsychiatric adverse effects of interferon-alpha: recognition and management. , 2005, CNS drugs.

[62]  Andrew H. Miller,et al.  Neuropsychiatric Adverse Effects of Interferon-α , 2005 .

[63]  B. Thierry,et al.  The tail suspension test: A new method for screening antidepressants in mice , 2004, Psychopharmacology.

[64]  H. Anisman,et al.  Synergistic effects of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha: central monoamine, corticosterone, and behavioral variations. , 2000, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

[65]  S. Maier,et al.  The pain of being sick: implications of immune-to-brain communication for understanding pain. , 2000, Annual review of psychology.

[66]  M. Maes,et al.  Major depression and activation of the inflammatory response system. , 1999, Advances in experimental medicine and biology.

[67]  T. Komori,et al.  ラットの視床下部および中脳におけるIL‐6およびIL‐6受容体のmRNA発現に対する拘束ストレスの影響 , 1997 .

[68]  M. Oitzl,et al.  Interleukin-1 beta, but not interleukin-6, impairs spatial navigation learning. , 1993, Brain Research.

[69]  R. Dantzer,et al.  Sickness behavior as a new target for drug development. , 1992, Trends in pharmacological sciences.