Understanding cellular networks to improve hematopoietic stem cell expansion cultures.

[1]  Keisuke Ito,et al.  Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells , 2006, Nature Medicine.

[2]  L. Pannell,et al.  Secretory protein enrichment and analysis: an optimized approach applied on cancer cell lines using 2D LC-MS/MS. , 2006, Journal of proteome research.

[3]  J. Falkenburg,et al.  Cytokine‐Dependent Proliferation of Human CD34+ Progenitor Cells in the Absence of Serum Is Suppressed by Their Progeny's Production of Serine Proteinases , 2006, Stem cells.

[4]  T. Kurosu,et al.  Reactive oxygen species generated by hematopoietic cytokines play roles in activation of receptor-mediated signaling and in cell cycle progression. , 2006, Cellular signalling.

[5]  H. Lodish,et al.  Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells , 2006, Nature Medicine.

[6]  John F. Kelly,et al.  Identification of Candidate Regulators of Embryonic Stem Cell Differentiation by Comparative Phosphoprotein Affinity Profiling*S , 2006, Molecular & Cellular Proteomics.

[7]  V. Cerundolo,et al.  Regulation of hematopoiesis in vitro and in vivo by invariant NKT cells. , 2005, Blood.

[8]  S. L. Wong,et al.  Towards a proteome-scale map of the human protein–protein interaction network , 2005, Nature.

[9]  Peter W Zandstra,et al.  Clonal evolution of stem and differentiated cells can be predicted by integrating cell‐intrinsic and ‐extrinsic parameters , 2005, Biotechnology and applied biochemistry.

[10]  J. Dick,et al.  Dynamic changes in cellular and microenvironmental composition can be controlled to elicit in vitro human hematopoietic stem cell expansion. , 2005, Experimental hematology.

[11]  E. Fuchs,et al.  Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle , 2005, PLoS biology.

[12]  Chris Sander,et al.  Signal Processing in the TGF-β Superfamily Ligand-Receptor Network , 2005, PLoS Comput. Biol..

[13]  I. Weissman,et al.  Differential Expression of Novel Potential Regulators in Hematopoietic Stem Cells , 2005, PLoS genetics.

[14]  S. de Vos,et al.  Transcriptional Profiling of Human Hematopoiesis During In Vitro Lineage‐Specific Differentiation , 2005, Stem cells.

[15]  Yukiko Matsuoka,et al.  Using process diagrams for the graphical representation of biological networks , 2005, Nature Biotechnology.

[16]  E. Vellenga,et al.  Inhibition of the Transforming Growth Factor β (TGFβ) Pathway by Interleukin-1β Is Mediated through TGFβ-activated Kinase 1 Phosphorylation of SMAD3 , 2005 .

[17]  Blagoy Blagoev,et al.  Mechanism of Divergent Growth Factor Effects in Mesenchymal Stem Cell Differentiation , 2005, Science.

[18]  H. Nakauchi,et al.  Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice. , 2005, Developmental cell.

[19]  P. Lansdorp Role of Telomerase in Hematopoietic Stem Cells , 2005, Annals of the New York Academy of Sciences.

[20]  Charles Auffray,et al.  Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[21]  Gabriel S. Eichler,et al.  Cell fates as high-dimensional attractor states of a complex gene regulatory network. , 2005, Physical review letters.

[22]  A. Jandrositz,et al.  Proteomic profiling of human stem cells derived from umbilical cord blood. , 2005, Biochemical and biophysical research communications.

[23]  M. Barcinski,et al.  Normal hematopoiesis is maintained by activated bone marrow CD4+ T cells. , 2005, Blood.

[24]  R. Barry,et al.  Quantitative protein profiling using antibody arrays , 2004, Proteomics.

[25]  L. Staudt,et al.  Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. , 2004, The New England journal of medicine.

[26]  S. Karpatkin,et al.  Hematopoiesis and stem cell renewal in long-term bone marrow cultures containing catalase. , 2004, Blood.

[27]  Mu Wang,et al.  Comparative Proteomic Analysis of Human CD34+ Stem/Progenitor Cells and Mature CD15+ Myeloid Cells , 2004, Stem cells.

[28]  C. Shaw,et al.  Molecular Signatures of Proliferation and Quiescence in Hematopoietic Stem Cells , 2004, PLoS biology.

[29]  L. Coulombel Identification of hematopoietic stem/progenitor cells: strength and drawbacks of functional assays , 2004, Oncogene.

[30]  G. Sauvageau,et al.  In vitro and in vivo expansion of hematopoietic stem cells , 2004, Oncogene.

[31]  M. Gerstein,et al.  Genomic analysis of regulatory network dynamics reveals large topological changes , 2004, Nature.

[32]  M. Mann,et al.  Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics , 2004, Nature Biotechnology.

[33]  Tetsuro Toyoda,et al.  Omic space: coordinate-based integration and analysis of genomic phenomic interactions , 2004, Bioinform..

[34]  P. Brown,et al.  Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[35]  Philippe Amouyel,et al.  Two‐dimensional maps and databases of the human macrophage proteome and secretome , 2004, Proteomics.

[36]  R. Pomerantz,et al.  HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[37]  Douglas A Lauffenburger,et al.  Multivariate proteomic analysis of murine embryonic stem cell self-renewal versus differentiation signaling. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[38]  S. Pelech Tracking cell signaling protein expression and phosphorylation by innovative proteomic solutions. , 2004, Current pharmaceutical biotechnology.

[39]  Fraser McBlane,et al.  Molecular Signatures of Self-Renewal, Differentiation, and Lineage Choice in Multipotential Hemopoietic Progenitor Cells In Vitro , 2004, Molecular and Cellular Biology.

[40]  A. Eaves,et al.  Identification and isolation of hematopoietic stem cells. , 2003, Archives of medical research.

[41]  P. Sorger,et al.  Profiling receptor tyrosine kinase activation by using Ab microarrays , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[42]  S. Weissman,et al.  Marrow Stem Cells Shift Gene Expression and Engraftment Phenotype with Cell Cycle Transit , 2003, The Journal of experimental medicine.

[43]  Ruedi Aebersold,et al.  Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry , 2003, Nature Biotechnology.

[44]  Peter W. Zandstra,et al.  Towards predictive models of stem cell fate , 2003, Cytotechnology.

[45]  T. Nakahata,et al.  Ex vivo expansion of hematopoietic stem cells by cytokines. , 2002, Biochimica et biophysica acta.

[46]  K. Krapfenbauer,et al.  Proteomic analysis of secreted muscle components: Search for factors involved in neuromuscular synapse formation , 2002, Proteomics.

[47]  A. Bodnar,et al.  Proteome analysis of conditioned medium from mouse embryonic fibroblast feeder layers which support the growth of human embryonic stem cells , 2002, Proteomics.

[48]  H. Sieburg,et al.  Deterministic regulation of hematopoietic stem cell self-renewal and differentiation. , 2002, Blood.

[49]  K. Moore,et al.  The AFT024 stromal cell line supports long-term ex vivo maintenance of engrafting multipotent human hematopoietic progenitors , 2002, Leukemia.

[50]  H. W. Lee,et al.  Dissociation between stem cell phenotype and NOD/SCID repopulating activity in human peripheral blood CD34(+) cells after ex vivo expansion. , 2001, Experimental hematology.

[51]  W. Mackin,et al.  The frontier of cellular medicine: expanding umbilical cord blood stem cells for clinical use. , 2001, Cancer journal.

[52]  M. Ratajczak,et al.  Numerous growth factors, cytokines, and chemokines are secreted by human CD34(+) cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner. , 2001, Blood.

[53]  M. Trevisan,et al.  Resolution of pluripotential intermediates in murine hematopoietic differentiation by global complementary DNA amplification from single cells: confirmation of assignments by expression profiling of cytokine receptor transcripts. , 2001, Blood.

[54]  Julia M. Francis,et al.  Transforming Growth Factor-β1 Induces Apoptosis Independently of p53 and Selectively Reduces Expression of Bcl-2 in Multipotent Hematopoietic Cells* , 2000, The Journal of Biological Chemistry.

[55]  G. Gilmore,et al.  Ex vivo expansion of human umbilical cord blood and peripheral blood CD34(+) hematopoietic stem cells. , 2000, Experimental hematology.

[56]  J. Reems,et al.  Serum supplement, inoculum cell density, and accessory cell effects are dependent on the cytokine combination selected to expand human HPCs ex vivo , 2000, Transfusion.

[57]  N. Nicola,et al.  The suppressors of cytokine signaling (SOCS) proteins: important feedback inhibitors of cytokine action. , 2000, Experimental hematology.

[58]  C. Furusawa,et al.  Theory of robustness of irreversible differentiation in a stem cell system: chaos hypothesis. , 2000, Journal of theoretical biology.

[59]  G C Overton,et al.  The genetic program of hematopoietic stem cells. , 2000, Science.

[60]  D. Vignali,et al.  Simultaneous quantitation of 15 cytokines using a multiplexed flow cytometric assay. , 1999, Journal of immunological methods.

[61]  M. Picardi,et al.  Long-lasting decrease of marrow and circulating long-term culture initiating cells after allogeneic bone marrow transplant , 1999, Bone Marrow Transplantation.

[62]  I. Fichtner,et al.  Differential Kinetics of Primitive Hematopoietic Cells Assayed In Vitro and In Vivo During Serum‐Free Suspension Culture of CD34+ Blood Progenitor Cells , 1999, Stem cells.

[63]  G. Ehninger,et al.  Defining Optimum Conditions for the Ex Vivo Expansion of Human Umbilical Cord Blood Cells. Influences of Progenitor Enrichment, Interference with Feeder Layers, Early‐Acting Cytokines and Agitation of Culture Vessels , 1999, Stem cells.

[64]  M. Loeffler,et al.  Interactions of erythropoietin, granulocyte colony-stimulating factor, stem cell factor, and interleukin-11 on murine hematopoiesis during simultaneous administration. , 1998, Blood.

[65]  P. Zandstra,et al.  Advances in hematopoietic stem cell culture. , 1998, Current opinion in biotechnology.

[66]  H. Mayani,et al.  Kinetics of Hematopoiesis in Dexter‐Type Long‐Term Cultures Established from Human Umbilical Cord Blood Cells , 1998, Stem cells.

[67]  N. Iscove,et al.  Hematopoietic stem cells expand during serial transplantation in vivo without apparent exhaustion , 1997, Current Biology.

[68]  G. Soslau,et al.  Cytokine mRNA expression in human platelets and a megakaryocytic cell line and cytokine modulation of platelet function. , 1997, Cytokine.

[69]  J. Dick,et al.  Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay. , 1997, Blood.

[70]  J. Dick,et al.  Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[71]  H. Miyazaki,et al.  Thrombopoietin augments ex vivo expansion of human cord blood-derived hematopoietic progenitors in combination with stem cell factor and flt3 ligand , 1997, Leukemia.

[72]  C. Eaves,et al.  Evidence of both ontogeny and transplant dose-regulated expansion of hematopoietic stem cells in vivo. , 1996, Blood.

[73]  S. Emerson,et al.  Ex vivo expansion of hematopoietic precursors, progenitors, and stem cells: the next generation of cellular therapeutics. , 1996, Blood.

[74]  G. Graham,et al.  Specificity and reciprocity in the interactions between TGF-beta and macrophage inflammatory protein-1 alpha. , 1996, Journal of immunology.

[75]  J G Bender,et al.  Effects of CD34+ cell selection and perfusion on ex vivo expansion of peripheral blood mononuclear cells. , 1995, Blood.

[76]  M. Koller,et al.  Growth factor consumption and production in perfusion cultures of human bone marrow correlate with specific cell production. , 1995, Experimental hematology.

[77]  M. Hansmann,et al.  Detection and quantification of transforming growth factor beta (TGF-beta) and platelet-derived growth factor (PDGF) release by normal human megakaryocytes. , 1995, Leukemia.

[78]  S. Jacobsen,et al.  The growth response of Lin-Thy-1+ hematopoietic progenitors to cytokines is determined by the balance between synergy of multiple stimulators and negative cooperation of multiple inhibitors. , 1994, Experimental hematology.

[79]  H E Wichmann,et al.  A COMPREHENSIVE MATHEMATICAL MODEL OF STEM CELL PROLIFERATION WHICH REPRODUCES MOST OF THE PUBLISHED EXPERIMENTAL RESULTS , 1980, Cell and tissue kinetics.

[80]  L. Lajtha,et al.  Conditions controlling the proliferation of haemopoietic stem cells in vitro , 1977, Journal of cellular physiology.

[81]  N. Fortunel,et al.  Control of hematopoietic stem/progenitor cell fate by transforming growth factor-beta. , 2003, Oncology research.

[82]  E. Papoutsakis,et al.  Reduced oxygen tension increases hematopoiesis in long-term culture of human stem and progenitor cells from cord blood and bone marrow. , 1992, Experimental hematology.