Preparation and characterization of wollastonite/titanium oxide nanofiber bioceramic composite as a future implant material

Abstract In this study, novel composites consisting of electrospun titanium dioxide (TiO 2 ) nanofibers incorporated into high-purity wollastonite glass ceramics were prepared as materials for use in hard tissue engineering applications. These materials were characterized and investigated by means of physical, mechanical and in vitro studies. The proposed composite showed greater densification and better mechanical characteristics compared to pure wollastonite. The influence of densification temperature and TiO 2 content was investigated. Typically, TiO 2 /wollastonite composites having 0, 10, 20 and 30 wt% metal oxide nanofibers were sintered at 900, 1100 and 1250 °C. The results indicated that increasing TiO 2 nanofibers content leads to increase the bulk density, compressive strength and microhardness with negligible, high and moderate influence for the densification temperature, respectively. While porosity and water adsorption capacity decreased with increasing the metal oxide nanofibers with a considerable impact for the sintering temperature in both properties. Moreover, bone-like apatite formed on the surface of wollastonite and wollastonite/TiO 2 nanofibers soaked in simulated body fluid (SBF). All these results show that the inclusion of TiO 2 nanofibers improved the characteristics of wollastonite while preserving its in vitro bioactivity; hence, the proposed composite may be used as a bone substitute in high load bearing sites.

[1]  S. Jee,et al.  Hydroxyapatite formation on bioactive-glazed alumina , 2003 .

[2]  P. Chu,et al.  Bioconductivity and mechanical properties of plasma-sprayed dicalcium silicate/zirconia composite coating , 2005 .

[3]  Serena M. Best,et al.  Bioceramics: Past, present and for the future , 2008 .

[4]  Sheryl E. Philip,et al.  Comparison of nanoscale and microscale bioactive glass on the properties of P(3HB)/Bioglass composites. , 2008, Biomaterials.

[5]  C. Tekmen,et al.  Titania nanofibers prepared by electrospinning , 2008 .

[6]  M. El-Newehy,et al.  Ni&Mn nanoparticles-decorated carbon nanofibers as effective electrocatalyst for urea oxidation , 2016 .

[7]  Masakazu Kawashita,et al.  Novel bioactive materials with different mechanical properties. , 2003, Biomaterials.

[8]  T. Webster,et al.  Nanotechnology and nanomaterials: Promises for improved tissue regeneration , 2009 .

[9]  X. Miao,et al.  Sol–gel derived bioglass as a coating materialfor porous alumina scaffolds , 2004 .

[10]  J. Lemons.  Ceramics: past, present, and future. , 1996, Bone.

[11]  M. Tanihara,et al.  Design of novel bioactive materials through organic modification of calcium silicate , 2007 .

[12]  M. El-Newehy,et al.  ZnO&Fe2O3-incoportaed TiO2 nanofibers as super effective photocatalyst for water splitting under visible light radiation , 2014 .

[13]  M. El-Newehy,et al.  Cobalt/copper-decorated carbon nanofibers as novel non-precious electrocatalyst for methanol electrooxidation , 2014, Nanoscale Research Letters.

[14]  Julian R Jones,et al.  Optimising bioactive glass scaffolds for bone tissue engineering. , 2006, Biomaterials.

[15]  N. Barakat,et al.  Synthesis and study of the photoluminescence and optical characteristics of Cd/CdO nanorods prepared by the electrospinning process , 2012 .

[16]  Nasser A.M. Barakat,et al.  Functionalization of Electrospun Titanium Oxide Nanofibers with Silver Nanoparticles: Strongly Effective Photocatalyst , 2009 .

[17]  K. Katti,et al.  Biomaterials in total joint replacement. , 2004, Colloids and surfaces. B, Biointerfaces.

[18]  N. Barakat,et al.  Cytogenetical and ecological studies of some wild congeneric species in the Solanaceae distributed in upper Egypt , 2010 .

[19]  M. S. Akhtar,et al.  Pd–Co-doped carbon nanofibers with photoactivity as effective counter electrodes for DSSCs , 2012 .

[20]  M. A. D. L. Casa-Lillo,et al.  Effect of materials’ processing methods on the ‘in vitro’ bioactivity of wollastonite glass-ceramic materials , 2005 .

[21]  Jiang Chang,et al.  Preparation of macroporous calcium silicate ceramics , 2004 .

[22]  N. Barakat,et al.  Titanium-based polymeric electrospun nanofiber mats as a novel organic semiconductor , 2012 .

[23]  Anmin Hu,et al.  Performances of CaSiO3 ceramic sintered by Spark plasma sintering , 2008 .

[24]  Sungho Jin,et al.  TiO2 nanotubes for bone regeneration. , 2012, Trends in biotechnology.

[25]  P. Chu,et al.  Mechanism of apatite formation on wollastonite coatings in simulated body fluids. , 2004, Biomaterials.

[26]  M. Neo,et al.  A comparative study between in vivo bone ingrowth and in vitro apatite formation on Na2O-CaO-SiO2 glasses. , 2003, Biomaterials.

[27]  S. Barcikowski,et al.  Production of Bioactive Nanomaterial Using Laser Generated Nanoparticles , 2009 .

[28]  W. Park,et al.  Plasma-treated poly(lactic-co-glycolic acid) nanofibers for tissue engineering , 2007 .

[29]  A. Hazar.  Preparation and in vitro bioactivity of CaSiO3 powders , 2007 .

[30]  Muzafar A. Kanjwal,et al.  Influence of temperature on the photodegradation process using Ag-doped TiO2 nanostructures: Negative impact with the nanofibers , 2013 .

[31]  Si-yu Ni,et al.  Study of the mechanical property and in vitro biocompatibility of CaSiO3 ceramics , 2005 .

[32]  Ming Li,et al.  Preparation and in vitro bioactivities of calcium silicate nanophase materials , 2005 .

[33]  F. A. Sheikh,et al.  Physiochemical characterizations of hydroxyapatite extracted from bovine bones by three different methods: extraction of biologically desirable Hap , 2008 .

[34]  K. Dušek,et al.  Biopolymers : Lignin, Proteins, Bioactive Nanocomposites , 2010 .

[35]  M. Khil,et al.  Extraction of pure natural hydroxyapatite from the bovine bones bio waste by three different methods , 2009 .

[36]  A. Elzatahry,et al.  Synthesis and characterization of CoMnO nanofibers supported on a graphite disk: Novel strategy for nanofibers immobilization , 2014 .

[37]  Jongee Park,et al.  Tribological properties of MgO -CaO -SiO2 -P2O5 -F -based glass-ceramic for dental applications , 2007 .

[38]  Hala Zreiqat,et al.  The effect of strontium incorporation into CaSiO3 ceramics on their physical and biological properties. , 2007, Biomaterials.

[39]  Y. Kameshima,et al.  Formation of hydroxyapatite on CaSiO3 powders in simulated body fluid , 2002 .