Feature enhancement framework for brain tumor segmentation and classification

Automatic medical image analysis is one of the key tasks being used by the medical community for disease diagnosis and treatment planning. Statistical methods are the major algorithms used and consist of few steps including preprocessing, feature extraction, segmentation, and classification. Performance of such statistical methods is an important factor for their successful adaptation. The results of these algorithms depend on the quality of images fed to the processing pipeline: better the images, higher the results. Preprocessing is the pipeline phase that attempts to improve the quality of images before applying the chosen statistical method. In this work, popular preprocessing techniques are investigated from different perspectives where these preprocessing techniques are grouped into three main categories: noise removal, contrast enhancement, and edge detection. All possible combinations of these techniques are formed and applied on different image sets which are then passed to a predefined pipeline of feature extraction, segmentation, and classification. Classification results are calculated using three different measures: accuracy, sensitivity, and specificity while segmentation results are calculated using dice similarity score. Statistics of five high scoring combinations are reported for each data set. Experimental results show that application of proper preprocessing techniques could improve the classification and segmentation results to a greater extent. However, the combinations of these techniques depend on the characteristics and type of data set used.

[1]  Dzulkifli Mohamad,et al.  Machine aided malaria parasitemia detection in Giemsa-stained thin blood smears , 2018, Neural Computing and Applications.

[2]  Ahmad Chaddad,et al.  Automated Feature Extraction in Brain Tumor by Magnetic Resonance Imaging Using Gaussian Mixture Models , 2015, Int. J. Biomed. Imaging.

[3]  Nello Cristianini,et al.  An Introduction to Support Vector Machines and Other Kernel-based Learning Methods , 2000 .

[4]  Andrius Usinskas,et al.  A SURVEY OF GENETIC ALGORITHMS APPLICATIONS FOR IMAGE ENHANCEMENT AND SEGMENTATION , 2007 .

[5]  .S Sivasundari,et al.  Review of MRI Image Classification Techniques , 2014 .

[6]  Corinna Cortes,et al.  Support-Vector Networks , 1995, Machine Learning.

[7]  Amjad Rehman,et al.  Removal of pectoral muscle based on topographic map and shape-shifting silhouette , 2018, BMC Cancer.

[8]  Youngjoon Han,et al.  Image Contrast Enhancement based Sub-histogram Equalization Technique without Over-equalization Noise , 2009 .

[9]  Giovanni Ramponi,et al.  Image enhancement via adaptive unsharp masking , 2000, IEEE Trans. Image Process..

[10]  Amjad Rehman,et al.  Computer-assisted brain tumor type discrimination using magnetic resonance imaging features , 2018, Biomedical engineering letters.

[11]  I K Fodor,et al.  A Survey of Dimension Reduction Techniques , 2002 .

[12]  Tanzila Saba,et al.  Brain tumor segmentation in multi‐spectral MRI using convolutional neural networks (CNN) , 2018, Microscopy research and technique.

[13]  Michael Kearns,et al.  A Bound on the Error of Cross Validation Using the Approximation and Estimation Rates, with Consequences for the Training-Test Split , 1995, Neural Computation.

[14]  Arend Heerschap,et al.  A chemometric approach for brain tumor classification using magnetic resonance imaging and spectroscopy. , 2003, Analytical chemistry.

[15]  Ayyaz Hussain,et al.  Fuzzy C-means and region growing based classification of tumor from mammograms using hybrid texture feature , 2018, J. Comput. Sci..

[16]  Tanzila Saba,et al.  Microscopic abnormality classification of cardiac murmurs using ANFIS and HMM , 2018, Microscopy research and technique.

[17]  Jitendra Malik,et al.  Scale-Space and Edge Detection Using Anisotropic Diffusion , 1990, IEEE Trans. Pattern Anal. Mach. Intell..

[18]  Andrzej Materka,et al.  DISCRETE WAVELET TRANSFORM – DERIVED FEATURES FOR DIGITAL IMAGE TEXTURE ANALYSIS , 2002 .

[19]  Amjad Rehman,et al.  Microscopic malaria parasitemia diagnosis and grading on benchmark datasets , 2018, Microscopy research and technique.

[20]  T. Saba,et al.  Image Enhancement and Segmentation Techniques for Detection of Knee Joint Diseases: A Survey , 2017, Current Medical Imaging Reviews.

[21]  Qianjin Feng,et al.  Enhanced Performance of Brain Tumor Classification via Tumor Region Augmentation and Partition , 2015, PloS one.

[22]  Robert M. Haralick,et al.  Textural Features for Image Classification , 1973, IEEE Trans. Syst. Man Cybern..

[23]  N. Otsu A threshold selection method from gray level histograms , 1979 .

[24]  Pieter Wesseling,et al.  International Society of Neuropathology‐Haarlem Consensus Guidelines for Nervous System Tumor Classification and Grading , 2014, Brain pathology.

[25]  Zahid Mehmood,et al.  Classification of acute lymphoblastic leukemia using deep learning , 2018, Microscopy research and technique.

[26]  Usha Mittal,et al.  Effect of Morphological Filters on Medical Image Segmentation using Improved Watershed Segmentation , 2013 .

[27]  Muhammad Sharif,et al.  Extraction of breast border and removal of pectoral muscle in wavelet domain , 2017 .

[28]  J. Austin,et al.  The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification. , 2015, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[29]  Jacob Benesty,et al.  New insights into the noise reduction Wiener filter , 2006, IEEE Transactions on Audio, Speech, and Language Processing.

[30]  Zahid Mehmood,et al.  Plasmodium life cycle stage classification based quantification of malaria parasitaemia in thin blood smears , 2018, Microscopy research and technique.

[31]  J. Verschakelen,et al.  Imaging techniques in lung cancer , 2011, Breathe.

[32]  Sonali Patil,et al.  Preprocessing To Be Considered For MR and CT Images Containing Tumors , 2012 .

[33]  Russell Greiner,et al.  A critical review of the effects of de-noising algorithms on MRI brain tumor segmentation , 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[34]  Y. J. Zhang,et al.  A survey on evaluation methods for image segmentation , 1996, Pattern Recognit..

[35]  Tanzila Saba,et al.  A novel classification scheme to decline the mortality rate among women due to breast tumor , 2018, Microscopy research and technique.

[36]  G. Vijaya,et al.  An Adaptive Preprocessing of Lung CT Images with Various Filters for Better Enhancement , 2014 .

[38]  Karel J. Zuiderveld,et al.  Contrast Limited Adaptive Histogram Equalization , 1994, Graphics Gems.

[39]  N. Suthanthira Vanitha,et al.  The Pre-Processing Techniques for Breast Cancer Detection in Mammography Images , 2013 .

[40]  Tanzila Saba,et al.  Automated nuclei segmentation of malignant using level sets , 2016, Microscopy research and technique.

[41]  M. Iqbal Saripan,et al.  Pre-processing Importance for Extracting Contours from Noisy Echocardiographic Images , 2009 .

[42]  M. Aribandi,et al.  Imaging features of invasive and noninvasive fungal sinusitis: a review. , 2007, Radiographics : a review publication of the Radiological Society of North America, Inc.

[43]  Mudassar Raza,et al.  Fundus image classification methods for the detection of glaucoma: A review , 2018, Microscopy research and technique.

[44]  Tanzila Saba,et al.  Retinal imaging analysis based on vessel detection , 2017, Microscopy research and technique.

[45]  J. Dunn,et al.  MRI monitoring of monocytes to detect immune stimulating treatment response in brain tumor , 2016, Neuro-oncology.

[46]  R. Zivadinov,et al.  The role of noninvasive and invasive diagnostic imaging techniques for detection of extra-cranial venous system anomalies and developmental variants , 2013, BMC Medicine.

[47]  P. Fieguth,et al.  A Gabor based technique for image denoising , 2005, Canadian Conference on Electrical and Computer Engineering, 2005..

[48]  Shenghuo Zhu,et al.  Improving medical/biological data classification performance by wavelet preprocessing , 2002, 2002 IEEE International Conference on Data Mining, 2002. Proceedings..

[49]  Amjad Rehman,et al.  Rouleaux red blood cells splitting in microscopic thin blood smear images via local maxima, circles drawing, and mapping with original RBCs , 2018, Microscopy research and technique.

[50]  Brian B. Avants,et al.  The Multimodal Brain Tumor Image Segmentation Benchmark (BRATS) , 2015, IEEE Transactions on Medical Imaging.