Supporting medication adherence in renal transplantation (SMART): a pilot RCT to improve adherence to immunosuppressive regimens

Abstract:  Background:  Although non‐adherence to an immunosuppressive regimen (NAH) is a major risk factor for poor outcome after renal transplantation (RTx), very few studies have examined non‐adherence intervention in this context. This pilot randomized controlled trial (RCT) tested the efficacy of an educational–behavioural intervention to increase adherence in non‐adherent RTx patients. We also assessed how NAH evolves over time.

[1]  S. De Geest,et al.  Supporting medication adherence in renal transplantation--the SMART study. , 2007, Swiss medical weekly.

[2]  S. Geest.  Subclinical noncompliance with immunosuppressive therapy in heart transplant recipients. A cluster analytic study , 2006 .

[3]  F. Dobbels,et al.  Prevalence, consequences, and determinants of nonadherence in adult renal transplant patients: a literature review , 2005, Transplant international : official journal of the European Society for Organ Transplantation.

[4]  E. Gordon,et al.  Can focusing on self-care reduce disparities in kidney transplantation outcomes? , 2005, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[5]  Evelyne Lerut,et al.  Prospective Study on Late Consequences of Subclinical Non‐Compliance with Immunosuppressive Therapy in Renal Transplant Patients , 2004, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[6]  Bartley P Griffith,et al.  An internet-based intervention to improve psychosocial outcomes in heart transplant recipients and family caregivers: development and evaluation. , 2004, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[7]  T. Fahey,et al.  How can we improve adherence to blood pressure-lowering medication in ambulatory care? Systematic review of randomized controlled trials. , 2004, Archives of internal medicine.

[8]  Caitlin E. Ryan,et al.  Electronic monitoring and counseling to improve medication adherence. , 2004, Behaviour research and therapy.

[9]  P. Roderick,et al.  Measuring compliance with drug regimens after renal transplantation: comparison of self-report and clinician rating with electronic monitoring , 2004, Transplantation.

[10]  M. Dimatteo,et al.  Social support and patient adherence to medical treatment: a meta-analysis. , 2004, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[11]  Min Sohn,et al.  High Rates of Sustained Smoking Cessation in Women Hospitalized With Cardiovascular Disease: The Women’s Initiative for Nonsmoking (WINS) , 2004, Circulation.

[12]  A. Hoes,et al.  Effect of a pharmacist-led intervention on diuretic compliance in heart failure patients: a randomized controlled study. , 2003, Journal of cardiac failure.

[13]  A. Peterson,et al.  Meta-analysis of trials of interventions to improve medication adherence. , 2003, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

[14]  K. Gréen,et al.  Measurement of compliance posttransplantation--the results of a 12-month study using electronic monitoring. , 2003, Transplantation proceedings.

[15]  P. Burkhart,et al.  Adherence to long-term therapies: evidence for action. , 2003, Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing.

[16]  T. Bodenheimer,et al.  Patient self-management of chronic disease in primary care. , 2002, JAMA.

[17]  E. van Wijngaerden,et al.  Nonadherence to highly active antiretroviral therapy: clinically relevant patient categorization based on electronic event monitoring. , 2002, AIDS research and human retroviruses.

[18]  T. Theruvath,et al.  Strategies to improve long-term outcomes after renal transplantation. , 2002, The New England journal of medicine.

[19]  M. Chisholm.  Enhancing transplant patients' adherence to medication therapy , 2002, Clinical transplantation.

[20]  M. Skeans,et al.  The natural history of azathioprine compliance after renal transplantation. , 2001, Kidney international.

[21]  B. Maes,et al.  The dialysis diet and fluid non-adherence questionnaire: validity testing of a self-report instrument for clinical practice. , 2001, Journal of clinical nursing.

[22]  S. Cupples,et al.  Use of behavioral contingency contracting with heart transplant candidates. , 2001, Progress in transplantation.

[23]  J. Hackman,et al.  A randomized, controlled trial of interventions to improve adherence to isoniazid therapy to prevent tuberculosis in injection drug users. , 2001, The American journal of medicine.

[24]  K A McKibbon,et al.  Interventions for helping patients to follow prescriptions for medications. , 2002, The Cochrane database of systematic reviews.

[25]  M K Campbell,et al.  Use of unequal randomisation to aid the economic efficiency of clinical trials , 2000, BMJ : British Medical Journal.

[26]  M. Dimatteo,et al.  Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. , 2000, Archives of internal medicine.

[27]  Susan Swindells,et al.  Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection , 2000, Annals of Internal Medicine.

[28]  K. Farmer,et al.  Methods for measuring and monitoring medication regimen adherence in clinical trials and clinical practice. , 1999, Clinical therapeutics.

[29]  P. Moons,et al.  Late acute rejection and subclinical noncompliance with cyclosporine therapy in heart transplant recipients. , 1998, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[30]  Judith A. Hall,et al.  Effectiveness of interventions to improve patient compliance: a meta-analysis. , 1998, Medical care.

[31]  B Vrijens,et al.  Comparing compliance patterns between randomized treatments. , 1997, Controlled clinical trials.

[32]  G. Traiger,et al.  A self-medication administration program for transplant recipients. , 1997, Critical care nurse.

[33]  A. Hoitsma,et al.  MEDICATION COMPLIANCE AFTER RENAL TRANSPLANTATION , 1995, Transplantation.

[34]  S. Geest,et al.  INCIDENCE, DETERMINANTS, AND CONSEQUENCES OF SUBCLINICAL NONCOMPLIANCE WITH IMMUNOSUPPRESSIVE THERAPY IN RENAL TRANSPLANT RECIPIENTS , 1995, Transplantation.

[35]  S. Geest,et al.  Development of the long-term medication behaviour self-efficacy scale: qualitative study for item development. , 1994, Journal of advanced nursing.

[36]  B. Mason,et al.  Pharmacists' Interventions Using an Electronic Medication-Event Monitoring Device'S Adherence Data versus Pill Counts , 1993, The Annals of pharmacotherapy.

[37]  R. Vargo,et al.  Teaching strategies for the transplant recipient: a review and future directions. , 1990, Focus on critical care.

[38]  Siegfried Lamnek,et al.  Methoden und Techniken , 1989 .

[39]  A. Bandura.  Self-efficacy: toward a unifying theory of behavioral change. , 1977, Psychological review.

[40]  A. Bandura.  Toward a unifying theory of behavioral change , 1977 .

[41]  A. Beck,et al.  An inventory for measuring depression. , 1961, Archives of general psychiatry.