Increased amplitude of P3 event-related potential in young binge drinkers.

The aim of the present study was to determine how binge drinking (BD) affects brain functioning in male and female university students during the performance of a visual discrimination task. Thirty two binge drinkers and 53 controls (non binge drinkers), with no history of other drug use, personal or family history of alcoholism or psychopathological disorders, were selected. Event-related potentials (ERPs) were recorded during the performance of a visual oddball task. The latency and amplitude of the N2 and P3b components of the ERPs were analyzed. There were no differences between the groups in behavioral measures, but P3b amplitudes were significantly larger in binge drinkers than controls. This may suggest the presence of anomalies in neural processes mediating attention processing, or an imbalance (increased) of neuronal activity in P3b generators caused by the presence of BD pattern for a long time.

[1]  D. Clark,et al.  Alcohol Use Disorders in Adolescents , 2002, Paediatric drugs.

[2]  Jerry L. Grenard,et al.  Affective decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in 10th grade Chinese adolescent binge drinkers , 2008, Neuropsychologia.

[3]  T. McCusker.  MAI Systems Corp. , 1993 .

[4]  John P. Allen,et al.  The alcohol use disorders identification test: an update of research findings. , 2007, Alcoholism, clinical and experimental research.

[5]  J. Polich,et al.  Neuropsychology and neuropharmacology of P3a and P3b. , 2006, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[6]  D. Gruol,et al.  Long-term potentiation in the rat hippocampus is reversibly depressed by chronic intermittent ethanol exposure. , 2002, Journal of neurophysiology.

[7]  M. J. Meloy,et al.  Blood oxygen level dependent response and spatial working memory in adolescents with alcohol use disorders. , 2004, Alcoholism, clinical and experimental research.

[8]  T. Sejnowski,et al.  Removing electroencephalographic artifacts by blind source separation. , 2000, Psychophysiology.

[9]  Pierre Maurage,et al.  The auditory-visual integration of anger is impaired in alcoholism: an event-related potentials study. , 2008, Journal of psychiatry & neuroscience : JPN.

[10]  F. Bloom,et al.  Meta-analysis of P300 amplitude from males at risk for alcoholism , 1994 .

[11]  Kenneth J Sher,et al.  Adolescence: booze, brains, and behavior. , 2005, Alcoholism, clinical and experimental research.

[12]  F. Crews,et al.  Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats. , 2000, Alcoholism, clinical and experimental research.

[13]  J. M. Silvers,et al.  Chronic intermittent ethanol exposure during adolescence blocks ethanol-induced inhibition of spontaneously active hippocampal pyramidal neurons. , 2006, Alcoholism, clinical and experimental research.

[14]  Frank J. Snyder,et al.  Longitudinal patterns of binge drinking among first year college students with a history of tobacco use. , 2009, Drug and alcohol dependence.

[15]  H. Wechsler,et al.  Health and behavioral consequences of binge drinking in college. A national survey of students at 140 campuses. , 1994, JAMA.

[16]  R. Johnson,et al.  On the neural generators of the P300 component of the event-related potential. , 2007, Psychophysiology.

[17]  H. Begleiter,et al.  The utility of neurophysiological markers in the study of alcoholism , 2005, Clinical Neurophysiology.

[18]  Maristela Monteiro,et al.  AUDIT - The alcohol use disorders identification test: guidelines for use in primary care. , 2001 .

[19]  G Mundle,et al.  Neuroimaging of gender differences in alcohol dependence: are women more vulnerable? , 2005, Alcoholism, clinical and experimental research.

[20]  H. Becker,et al.  The alcohol withdrawal "kindling" phenomenon: clinical and experimental findings. , 1996, Alcoholism, clinical and experimental research.

[21]  J. Polich.  Updating P300: An integrative theory of P3a and P3b , 2007, Clinical Neurophysiology.

[22]  Fernando Cadaveira,et al.  Binge drinking and declarative memory in university students. , 2011, Alcoholism, clinical and experimental research.

[23]  Francisco Caamaño-Isorna,et al.  Definición del concepto de consumo intensivo de alcohol adolescente (binge drinking) , 2011 .

[24]  Susan F Tapert,et al.  A preliminary study of functional magnetic resonance imaging response during verbal encoding among adolescent binge drinkers. , 2010, Alcohol.

[25]  E. Levin,et al.  Binge pattern ethanol exposure in adolescent and adult rats: differential impact on subsequent responsiveness to ethanol. , 2000, Alcoholism, clinical and experimental research.

[26]  Jonathan R. Folstein,et al.  Influence of cognitive control and mismatch on the N2 component of the ERP: a review. , 2007, Psychophysiology.

[27]  C. Grau,et al.  Effects of age on event-related potentials in chronic alcoholics: a multimodal study. , 1992, Neuropsychobiology.

[28]  C. Guerri,et al.  Mechanisms involved in the neurotoxic, cognitive, and neurobehavioral effects of alcohol consumption during adolescence. , 2010, Alcohol.

[29]  Jae Eun Lee,et al.  Erratum: Trends in college binge drinking during a period of increased prevention efforts: Findings from 4 Harvard School of Public Health College Alcohol Study Surveys: 1993-2001 (Journal of American College Health (2002) 50:5 (203-217)) , 2002 .

[30]  C. Grau,et al.  Multimodality exploration of event-related potentials in chronic alcoholics. , 1991, Alcoholism, clinical and experimental research.

[31]  Mark B Johnson,et al.  College binge drinking: what is it? Who does it? , 2002, Alcoholism, clinical and experimental research.

[32]  R. Hale,et al.  Repeated episodes of ethanol withdrawal potentiate the severity of subsequent withdrawal seizures: an animal model of alcohol withdrawal "kindling". , 1993, Alcoholism, clinical and experimental research.

[33]  B. Feige,et al.  Auditory and visual event-related potentials in alcoholics: abnormalities of components and brain electrical field , 2000, European Archives of Psychiatry and Clinical Neuroscience.

[34]  Susan F Tapert,et al.  Gender and adolescent alcohol use disorders on BOLD (blood oxygen level dependent) response to spatial working memory. , 2005, Alcohol and alcoholism.

[35]  B. Bartholow,et al.  Specificity of P3 event-related potential reactivity to alcohol cues in individuals low in alcohol sensitivity. , 2010, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[36]  T. Duka,et al.  Cognitive and emotional consequences of binge drinking: role of amygdala and prefrontal cortex , 2008, Philosophical Transactions of the Royal Society B: Biological Sciences.

[37]  John R. Williams.  The Declaration of Helsinki and public health. , 2008, Bulletin of the World Health Organization.

[38]  K. Sher,et al.  Decision making and binge drinking: a longitudinal study. , 2007, Alcoholism, clinical and experimental research.

[39]  Patrick M. O'Malley,et al.  Monitoring the Future National Results on Adolescent Drug Use: Overview of Key Findings, 2004. , 2003 .

[40]  J. Ford,et al.  Event-related potentials in alcoholic men: P3 amplitude reflects family history but not alcohol consumption. , 1991, Alcoholism, clinical and experimental research.

[41]  Matcheri S Keshavan,et al.  Prefrontal cortex, thalamus, and cerebellar volumes in adolescents and young adults with adolescent-onset alcohol use disorders and comorbid mental disorders. , 2005, Alcoholism, clinical and experimental research.

[42]  S. McCabe,et al.  Drinking Like a Guy: Frequent Binge Drinking Among Undergraduate Women , 2005, Substance use & misuse.

[43]  S. Tapert,et al.  Reduced hippocampal volume among adolescents with alcohol use disorders without psychiatric comorbidity , 2005, Psychiatry Research: Neuroimaging.

[44]  R. Jouvent,et al.  522 Attentional withdrawal and smoking cessation: A longitudinal ERP study , 1998 .

[45]  F. Crews,et al.  Consequences of multiple withdrawals from alcohol. , 2004, Alcoholism, clinical and experimental research.

[46]  Peter J. Anderson,et al.  Executive functions and the frontal lobes: A lifespan perspective. , 2008 .

[47]  M. Timsit-Berthier,et al.  Les potentiels évoqués cognitifs chez les patients alcooliques : évaluation du risque de rechute , 2003, Neurophysiologie Clinique/Clinical Neurophysiology.

[48]  T. Duka,et al.  Patterns of alcohol drinking in a population of young social drinkers: a comparison of questionnaire and diary measures. , 2002, Alcohol and alcoholism.

[49]  F. Cadaveira,et al.  Event-related potentials elicited by a visual continuous performance task in children of alcoholics. , 1999, Alcohol.

[50]  C. Kornreich,et al.  Chronic alcoholism: Insights from neurophysiology , 2009, Neurophysiologie Clinique/Clinical Neurophysiology.

[51]  F. Cadaveira,et al.  Reduced anterior prefrontal cortex activation in young binge drinkers during a visual working memory task. , 2010, Drug and alcohol dependence.

[52]  A. Hervonen,et al.  Interaction of aging and intermittent ethanol exposure on brain cytochrome c oxidase activity levels. , 2003, Alcohol.

[53]  Matt Stevenson,et al.  Alcohol Use Disorders Identification Test , 2010 .

[54]  B. Bartholow,et al.  Effects of alcohol sensitivity on P3 event-related potential reactivity to alcohol cues. , 2007, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[55]  D. Hommer,et al.  Evidence for a gender-related effect of alcoholism on brain volumes. , 2001, The American journal of psychiatry.

[56]  Cinzia R. De Luca and Richard J. Leventer.  Developmental trajectories of executive functions across the lifespan , 2010 .

[57]  David Gilder,et al.  P3 components and adolescent binge drinking in Southwest California Indians. , 2007, Neurotoxicology and teratology.

[58]  J. Rohrbaugh,et al.  Amplitude of visual P3 event-related potential as a phenotypic marker for a predisposition to alcoholism: preliminary results from the COGA Project. Collaborative Study on the Genetics of Alcoholism. , 1998, Alcoholism: Clinical and Experimental Research.

[59]  Terry L. Jernigan,et al.  Longitudinal characterization of white matter maturation during adolescence , 2010, Brain Research.

[60]  S. Tapert,et al.  Prefrontal cortex volumes in adolescents with alcohol use disorders: unique gender effects. , 2008, Alcoholism, clinical and experimental research.

[61]  J. Vejnoska,et al.  ALCOHOL HEALTH AND RESEARCH WORLD , 1983 .

[62]  Jan S Gill,et al.  Reported levels of alcohol consumption and binge drinking within the UK undergraduate student population over the last 25 years. , 2002, Alcohol and alcoholism.

[63]  J. Nurnberger,et al.  A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. , 1994, Journal of studies on alcohol.

[64]  Fernando Cadaveira,et al.  Binge drinking affects attentional and visual working memory processing in young university students. , 2009, Alcoholism, clinical and experimental research.

[65]  J. Rohrbaugh,et al.  Amplitude of visual P3 event-related potential as a phenotypic marker for a predisposition to alcoholism: preliminary results from the COGA Project. Collaborative Study on the Genetics of Alcoholism. , 1998, Alcoholism, clinical and experimental research.

[66]  S. Tapert,et al.  Adolescence and the Trajectory of Alcohol Use: Basic to Clinical Studies , 2004, Annals of the New York Academy of Sciences.

[67]  John Polich,et al.  Binge drinking in young adults: Data, definitions, and determinants. , 2009, Psychological bulletin.

[68]  T. Duka,et al.  Binge drinking, cognitive performance and mood in a population of young social drinkers. , 2005, Alcoholism, clinical and experimental research.

[69]  W. Iacono,et al.  The heritability of P300 amplitude in 18-year-olds is robust to adolescent alcohol use. , 2009, Psychophysiology.

[70]  H. Wechsler,et al.  Trends in College Binge Drinking During a Period of Increased Prevention Efforts: Findings from 4 Harvard School of Public Health College Alcohol Study Surveys: 1993–2001 , 2002, Journal of American college health : J of ACH.

[71]  John Polich,et al.  Alcoholism risk, tobacco smoking, and P300 event-related potential , 2004, Clinical Neurophysiology.

[72]  P. Philippot,et al.  Latent deleterious effects of binge drinking over a short period of time revealed only by electrophysiological measures. , 2009, Journal of psychiatry & neuroscience : JPN.

[73]  Robert D Brewer,et al.  Trends in alcohol use and binge drinking, 1985-1999: results of a multi-state survey. , 2004, American journal of preventive medicine.

[74]  J. W. Rohrbaugh,et al.  The P300 brain potential is reduced in smokers , 2000, Psychopharmacology.

[75]  F. Cadaveira,et al.  Factors associated with risky consumption and heavy episodic drinking among Spanish university students. , 2008, Journal of studies on alcohol and drugs.

[76]  Luis M. García-Moreno,et al.  Actividad prefrontal y alcoholismo de fin de semana en jóvenes , 2008 .

[77]  H. Becker.  Kindling in Alcohol Withdrawal , 1998, Alcohol health and research world.