ActivationProcessing and in Th1 But Not Th2 Cell Microglia Are More Efficient Than Astrocytes in

AdoriniFrancesca Aloisi, Francesco Ria, Giuseppe Penna and Lucianohttp://www.jimmunol.org/content/160/10/4671J Immunol€1998; 160:4671-4680; ;Referenceshttp://www.jimmunol.org/content/160/10/4671.full#ref-list-1This article cites 68 articles, 24 of which you can access for free at: Subscriptionshttp://jimmunol.org/subscriptionsInformation about subscribing to The Journal of Immunology is online at: Permissionshttp://www.aai.org/ji/copyright.htmlSubmit copyright permission requests at: Email Alertshttp://jimmunol.org/cgi/alerts/etocReceive free email-alerts when new articles cite this article. Sign up at:

[1]  P. Vanguri,et al.  Ia expression and antigen presentation by glia: strain and cell type-specific differences among rat astrocytes and microglia , 1997, Journal of Neuroimmunology.

[2]  G. Wong,et al.  Inducible expression of H–2 and Ia antigens on brain cells , 1984, Nature.

[3]  H. Link,et al.  Review: cytokines and the pathogenesis of multiple sclerosis , 1996, Journal of neuroscience research.

[4]  C. Raine,et al.  The adhesion molecule and cytokine profile of multiple sclerosis lesions , 1995, Annals of neurology.

[5]  V. Maino,et al.  Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations , 1995, The Journal of experimental medicine.

[6]  J. Sedgwick,et al.  Microglia induce CD4 T lymphocyte final effector function and death , 1996, The Journal of experimental medicine.

[7]  H. Mcdevitt,et al.  Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. , 1995, Immunology today.

[8]  Y. Matsumoto,et al.  In situ inactivation of infiltrating T cells in the central nervous system with autoimmune encephalomyelitis. The role of astrocytes. , 1993, Immunology.

[9]  K. Gordon,et al.  IFN-gamma-activated primary murine astrocytes express B7 costimulatory molecules and prime naive antigen-specific T cells. , 1997, Journal of immunology.

[10]  W. Hickey,et al.  T‐lymphocyte entry into the central nervous system , 1991, Journal of neuroscience research.

[11]  H. Weiner,et al.  Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. , 1994, Science.

[12]  K. Frei,et al.  Antigen presentation and tumor cytotoxicity by interferon‐γ‐treated microglial cells , 1987 .

[13]  L. Adorini,et al.  Soluble protein but not peptide administration diverts the immune response of a clonal CD4+ T cell population to the T helper 2 cell pathway. , 1996, Journal of immunology.

[14]  Michael Loran Dustin,et al.  The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-λ, tumor necrosis factor α, lymphotoxin, and interleukin-1: relevance to intracerebral antigen presentation , 1989, Journal of Neuroimmunology.

[15]  S. Styren,et al.  Molecular, cellular, and pathologic characterization of HLA-DR immunoreactivity in normal elderly and Alzheimer's disease brain , 1990, Experimental Neurology.

[16]  Susanne A. Fischer,et al.  Interleukin‐12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (Th1) but not on Th2 cells , 1993, European journal of immunology.

[17]  G. Levi,et al.  Analysis of B7-1 and B7-2 costimulatory ligands in cultured mouse microglia: upregulation by interferon-γ and lipopolysaccharide and downregulation by interleukin-10, prostaglandin E2 and cyclic AMP-elevating agents , 1997, Journal of Neuroimmunology.

[18]  B. Trapp,et al.  Detection of MHC class II-antigens on macrophages and microglia, but not on astrocytes and endothelia in active multiple sclerosis lesions , 1994, Journal of Neuroimmunology.

[19]  H. Lassmann,et al.  Cellular immune reactivity within the CNS , 1986, Trends in Neurosciences.

[20]  E. Sercarz,et al.  Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. , 1989, Cellular immunology.

[21]  Paul C. Rogers,et al.  From Naive to Memory T Cells , 1996, Immunological reviews.

[22]  J. Merrill,et al.  Lymphokines and immunoregulatory molecules in subacute sclerosing panencephalitis. , 1991, Clinical immunology and immunopathology.

[23]  R. Hohlfeld,et al.  Human astrocytes are only partially competent antigen presenting cells. Possible implications for lesion development in multiple sclerosis. , 1994, Brain : a journal of neurology.

[24]  K. Williams,et al.  Induction of primary T cell responses by human glial cells , 1993, Journal of neuroscience research.

[25]  P. Knopf,et al.  Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view. , 1992, Immunology today.

[26]  J. Antel,et al.  Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro. , 1996, The Journal of clinical investigation.

[27]  T. Mosmann,et al.  Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies , 1987, The Journal of experimental medicine.

[28]  L. Eng,et al.  Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence. , 1972, Brain research.

[29]  G. Trinchieri Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. , 1995, Annual review of immunology.

[30]  L. Adorini,et al.  Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)- microglobulin-deficient BALB/c mice , 1996, The Journal of experimental medicine.

[31]  T. Owens,et al.  Selective enrichment of Th1 CD45RBlow CD4+ T cells in autoimmune infiltrates in experimental allergic encephalomyelitis. , 1994, International immunology.

[32]  C. D. DE GROOT,et al.  Determination of the origin and nature of brain macrophages and microglial cells in mouse central nervous system, using non‐radioactive in situ hybridization and immunoperoxidase techniques , 1992, Glia.

[33]  G. Kreutzberg Microglia: a sensor for pathological events in the CNS , 1996, Trends in Neurosciences.

[34]  T. Mosmann,et al.  The expanding universe of T-cell subsets: Th1, Th2 and more. , 1996, Immunology today.

[35]  R. Hohlfeld,et al.  Multiple sclerosis. Immunomodulatory effects of human astrocytes on T cells. , 1994, Brain : a journal of neurology.

[36]  H. Lassmann,et al.  Intrathecal application of interferon gamma. Progressive appearance of MHC antigens within the rat nervous system. , 1990, The American journal of pathology.

[37]  E. Appella,et al.  Mechanisms influencing the immunodominance of T cell determinants , 1988, The Journal of experimental medicine.

[38]  L. Adorini,et al.  IL-12 production by central nervous system microglia is inhibited by astrocytes. , 1997, Journal of immunology.

[39]  Y. Matsumoto,et al.  Immunohistochemical analysis of the rat central nervous system during experimental allergic encephalomyelitis, with special reference to Ia-positive cells with dendritic morphology. , 1986, Journal of immunology.

[40]  G. Trinchieri,et al.  B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation , 1994, The Journal of experimental medicine.

[41]  G. Kreutzberg,et al.  Microglia in the immune surveillance of the brain: Human microglia constitutively express HLA-DR molecules , 1993, Journal of Neuroimmunology.

[42]  M. Hart,et al.  CNS antigen presentation , 1995, Trends in Neurosciences.

[43]  A. Aruffo,et al.  CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[44]  C. Maliszewski,et al.  Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction , 1995, European journal of immunology.

[45]  G. Powers,et al.  Monoclonal antibody 2D10 recognizes a novel T cell costimulatory molecule on activated murine B lymphocytes. , 1994, Journal of immunology.

[46]  A. Heimberger,et al.  Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. , 1990, Science.

[47]  J. Antel,et al.  B7/BB‐1 antigen expression on adult human microglia studied in vitro and in situ , 1994, European journal of immunology.

[48]  R. Simone,et al.  The Costimulatory Molecule B7 is Expressed on Human Microglia in Culture and in Multiple Sclerosis Acute Lesions , 1995, Journal of neuropathology and experimental neurology.

[49]  M. Graeber,et al.  Functional plasticity of microglia: A review , 1988, Glia.

[50]  P. Comoglio,et al.  Monoclonal antibodies against murine gamma interferon. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[51]  P. Lebon,et al.  Interferon-γ and Ia antigen are present on astrocytes in active chronic multiple sclerosis lesions , 1988, Journal of the Neurological Sciences.

[52]  S. Miller,et al.  Evolution of the T‐Cell Repertoire during the Course of Experimental Immune‐Mediated Demyelinating Diseases , 1995, Immunological reviews.

[53]  Y. Matsumoto,et al.  Immune regulation by brain cells in the central nervous system: microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditions. , 1992, Immunology.

[54]  E. Shevach,et al.  Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. , 1994 .

[55]  L. Turka,et al.  Immunological functions of non-professional antigen-presenting cells: new insights from studies of T-cell interactions with keratinocytes. , 1994, Immunology today.

[56]  A. Lanzavecchia,et al.  Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation , 1996, The Journal of experimental medicine.

[57]  V. ter meulen,et al.  Major histocompatibility complex-expressing nonhematopoietic astroglial cells prime only CD8+ T lymphocytes: astroglial cells as perpetuators but not initiators of CD4+ T cell responses in the central nervous system , 1991, The Journal of experimental medicine.

[58]  H. Weiner,et al.  Immunologic Mechanisms and Therapy in Multiple Sclerosis , 1995, Immunological reviews.

[59]  Sunhee C. Lee,et al.  Multiple Sclerosis: A Role for Astroglia in Active Demyelination Suggested by Class II MHC Expression and Ultrastructural Study , 1990, Journal of neuropathology and experimental neurology.

[60]  W. Fierz,et al.  Astrocytes present myelin basic protein to encephalitogenic T-cell lines , 1984, Nature.

[61]  Kenneth M. Murphy,et al.  Functional diversity of helper T lymphocytes , 1996, Nature.

[62]  L. Adorini,et al.  The role of IL-12 in the induction of organ-specific autoimmune diseases. , 1995, Immunology today.

[63]  M. Hart,et al.  Differential activation of Th1 and Th2 CD4+ cells by murine brain microvessel endothelial cells and smooth muscle/pericytes. , 1993, Journal of immunology.

[64]  G. Trinchieri,et al.  Astrocytes and Microglia Produce Interleukin‐12 p40 a , 1996, Annals of the New York Academy of Sciences.

[65]  M. Cuzner,et al.  Microglia are the major cell type expressing MHC class II in human white matter , 1987, Journal of the Neurological Sciences.

[66]  D. Hafler,et al.  Restricted T cell expression of IL-2/IFN-gamma mRNA in human inflammatory disease. , 1991, Journal of immunology.

[67]  V. ter meulen,et al.  Resident macrophages (ramified microglia) of the adult brown Norway rat central nervous system are constitutively major histocompatibility complex class II positive , 1993, The Journal of experimental medicine.

[68]  O. Rott,et al.  Microglial cells qualify as the stimulators of unprimed CD4+ and CD8+ T lymphocytes in the central nervous system , 1994, Clinical and experimental immunology.