Magnetic particle diverter in an integrated microfluidic format

A fully integrated micromagnetic particle diverter and microfluidic system are described. Particles are diverted via an external uniform magnetic field perturbed at the microscale by underlying current straps. The resulting magnetic force deflects particles across a flow stream into one of the two channels at a Y-shaped junction. The basic theoretical framework, design, and operational demonstration of the device are presented.

[1]  Amar Rida,et al.  Long-range transport of magnetic microbeads using simple planar coils placed in a uniform magnetostatic field , 2003 .

[2]  Hugo Ferreira,et al.  Single magnetic microsphere placement and detection on-chip using current line designs with integrated spin valve sensors: Biotechnological applications , 2002 .

[3]  Mala L. Radhakrishnan,et al.  Manipulation of magnetic microbeads in suspension using micromagnetic systems fabricated with soft lithography , 2001 .

[4]  Marc D. Porter,et al.  Design of integrated microfluidic device for sorting magnetic beads in biological assays , 2001 .

[5]  A. Weiss,et al.  Detection and characterization of carcinoma cells in the blood. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[6]  Hakho Lee,et al.  Microelectromagnets for the control of magnetic nanoparticles , 2001 .

[7]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[8]  Gareth P. Hatch,et al.  Magnetic design considerations for devices and particles used for biological high-gradient magnetic separation (HGMS) systems , 2001 .

[9]  Andrew G. Glen,et al.  APPL , 2001 .

[10]  H. B. Halsall,et al.  Development and Characterization of Microfluidic Devices and Systems for Magnetic Bead-Based Biochemical Detection , 2001 .

[11]  R. Birss,et al.  High Gradient Magnetic Separation , 1983 .

[12]  Andreas Radbruch,et al.  Cell separation methods and applications , 1998 .

[13]  S. Frost,et al.  Using magnetic beads to isolate inside-out GLUT1-containing vesicles from 3T3-L1 adipocyte plasma membranes. , 1997, Analytical biochemistry.

[14]  Maciej Zborowski,et al.  Continuous cell separation using novel magnetic quadrupole flow sorter , 1999 .

[15]  R. C. Weast.  CRC Handbook of Chemistry and Physics , 1973 .