EVALUATION OF FRESH AND CRYOPRESERVED HEPATOCYTES AS IN VITRO DRUG METABOLISM TOOLS FOR THE PREDICTION OF METABOLIC CLEARANCE
暂无分享,去创建一个
Robert J Riley | Dermot F McGinnity | R. Urbanowicz | R. Riley | M. Soars | D. Mcginnity | Matthew G Soars | Richard A Urbanowicz
[1] J B Houston,et al. Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance. , 1994, Biochemical pharmacology.
[2] Relevance of in vitro kinetic parameters to in vivo metabolism of xenobiotics. , 1994, Toxicology in vitro : an international journal published in association with BIBRA.
[3] R. Foti,et al. Flavin-containing monooxygenase activity in hepatocytes and microsomes: in vitro characterization and in vivo scaling of benzydamine clearance. , 2002, Drug metabolism and disposition: the biological fate of chemicals.
[4] D. Utesch,et al. Metabolic activity of fresh and cryopreserved dog hepatocyte suspensions. , 1998, Xenobiotica; the fate of foreign compounds in biological systems.
[5] K. Pang,et al. Retention of transporter activities in cryopreserved, isolated rat hepatocytes. , 2003, Drug metabolism and disposition: the biological fate of chemicals.
[6] A. Dennison,et al. Cryopreservation of hepatocytes: a review of current methods for banking , 2004, Cell and Tissue Banking.
[7] R. Obach,et al. Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes. , 1999, Drug metabolism and disposition: the biological fate of chemicals.
[8] J B Houston,et al. Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices. , 1997, Drug metabolism reviews.
[9] Masato Chiba,et al. Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method. , 2002, Drug metabolism and disposition: the biological fate of chemicals.
[10] R C Chou,et al. Integration of in vitro data into allometric scaling to predict hepatic metabolic clearance in man: application to 10 extensively metabolized drugs. , 1997, Journal of pharmaceutical sciences.
[11] A. Li,et al. Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. , 1999, Chemico-biological interactions.
[12] I Mahmood,et al. The Pharmacokinetic Principles Behind Scaling from Preclinical Results to Phase I Protocols , 1999, Clinical pharmacokinetics.
[13] R. Plumb,et al. Application of a generic fast gradient liquid chromatography tandem mass spectrometry method for the analysis of cytochrome P450 probe substrates. , 1998, Rapid communications in mass spectrometry : RCM.
[14] G R Wilkinson,et al. Prediction of hepatic extraction ratio from in vitro measurement of intrinsic clearance. , 1977, The Journal of pharmacology and experimental therapeutics.
[15] T Ishizaki,et al. Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data. , 1997, Pharmacology & therapeutics.
[16] Yau Yi Lau,et al. Development of a novel in vitro model to predict hepatic clearance using fresh, cryopreserved, and sandwich-cultured hepatocytes. , 2002, Drug metabolism and disposition: the biological fate of chemicals.
[17] D. Jaeck,et al. The Use of Human Hepatocytes to Select Compounds Based on Their Expected Hepatic Extraction Ratios in Humans , 1997, Pharmaceutical Research.
[18] F. Oesch,et al. Cultures with cryopreserved hepatocytes: applicability for studies of enzyme induction. , 2000, Chemico-biological interactions.
[19] R. Riley,et al. Automated definition of the enzymology of drug oxidation by the major human drug metabolizing cytochrome P450s. , 2000, Drug metabolism and disposition: the biological fate of chemicals.
[20] L. Goodman,et al. The Pharmacological Basis of Therapeutics , 1941 .
[21] F. Oesch,et al. Metabolic activity of fresh and cryopreserved cynomolgus monkey (Macaca fascicularis) hepatocytes , 2000, Xenobiotica; the fate of foreign compounds in biological systems.
[22] B. Burchell,et al. In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance. , 2002, The Journal of pharmacology and experimental therapeutics.
[23] B. Hoener,et al. Predicting the hepatic clearance of xenobiotics in humans from in vitro data , 1994, Biopharmaceutics & drug disposition.
[24] A. Galetin,et al. Progress Towards Prediction of Human Pharmacokinetic Parameters from In Vitro Technologies , 2003, Drug metabolism reviews.
[25] R. Obach,et al. Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol. , 1997, Drug metabolism and disposition: the biological fate of chemicals.
[26] N. Hewitt,et al. Studies comparing in vivo:in vitro metabolism of three pharmaceutical compounds in rat, dog, monkey, and human using cryopreserved hepatocytes, microsomes, and collagen gel immobilized hepatocyte cultures. , 2001, Drug metabolism and disposition: the biological fate of chemicals.
[27] G. Granneman,et al. Use of In Vitro and In Vivo Data to Estimate the Likelihood of Metabolic Pharmacokinetic Interactions , 1997, Clinical pharmacokinetics.
[28] T Lavé,et al. Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques. , 1999, Journal of medicinal chemistry.
[29] R. Obach. The importance of nonspecific binding in in vitro matrices, its impact on enzyme kinetic studies of drug metabolism reactions, and implications for in vitro-in vivo correlations. , 1996, Drug metabolism and disposition: the biological fate of chemicals.
[30] J. Silva,et al. Induction of cytochrome-P450 in cryopreserved rat and human hepatocytes. , 1999, Chemico-biological interactions.
[31] R J Riley,et al. Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential. , 1999, Xenobiotica; the fate of foreign compounds in biological systems.
[32] T Lavé,et al. Prediction of Hepatic Metabolic Clearance , 2001, Clinical pharmacokinetics.
[33] F. Oesch,et al. Drug metabolizing capacity of cryopreserved human, rat, and mouse liver parenchymal cells in suspension. , 1999, Drug metabolism and disposition: the biological fate of chemicals.
[34] M. Leider. Goodman & Gilman's The Pharmacological Basis of Therapeutics , 1985 .
[35] T Lavé,et al. Prediction of Hepatic Metabolic Clearance Based on Interspecies Allometric Scaling Techniques and In Vitro-In Vivo Correlations , 1999, Clinical pharmacokinetics.
[36] Albert P. Li. Overview: hepatocytes and cryopreservation--a personal historical perspective. , 1999, Chemico-biological interactions.
[37] Y. Ishii,et al. A convenient in vitro screening method for predicting in vivo drug metabolic clearance using isolated hepatocytes suspended in serum. , 2000, Drug metabolism and disposition: the biological fate of chemicals.
[38] Prediction of in vivo hepatic clearance from in vitro data using cryopreserved human hepatocytes , 2003, Xenobiotica; the fate of foreign compounds in biological systems.
[39] Scott L Cockroft,et al. The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties. , 2002, Drug metabolism and disposition: the biological fate of chemicals.
[40] I Mahmood,et al. Interspecies scaling of renally secreted drugs. , 1998, Life sciences.
[41] D J Rance,et al. The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data. , 1997, The Journal of pharmacology and experimental therapeutics.