Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein

[1]  Ho Chul Kang,et al.  Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3 , 2016, Science.

[2]  John Q Trojanowski,et al.  Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease , 2016, The Journal of experimental medicine.

[3]  Y. Shim,et al.  Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function , 2016, Autophagy.

[4]  P. Calabresi,et al.  Lysosomal Dysfunction and α‐Synuclein Aggregation in Parkinson's Disease: Diagnostic Links , 2016, Movement disorders : official journal of the Movement Disorder Society.

[5]  Evangelia Emmanouilidou,et al.  Exocytosis and Spreading of Normal and Aberrant α‐Synuclein , 2016, Brain pathology.

[6]  D. Krainc,et al.  Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway , 2016, Journal of Neuroscience.

[7]  P. Brundin,et al.  Sorting out release, uptake and processing of alpha‐synuclein during prion‐like spread of pathology , 2016, Journal of neurochemistry.

[8]  M. Wegrzynowicz,et al.  Synaptic failure and α‐synuclein , 2016, Movement disorders : official journal of the Movement Disorder Society.

[9]  H. Braak,et al.  Review: Sporadic Parkinson's disease: development and distribution of α‐synuclein pathology , 2016, Neuropathology and applied neurobiology.

[10]  K. Luk,et al.  Bent out of shape: α‐Synuclein misfolding and the convergence of pathogenic pathways in Parkinson's disease , 2015, FEBS letters.

[11]  E. Joe,et al.  Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson’s disease , 2015, Molecular Neurodegeneration.

[12]  Jacqueline Burré The Synaptic Function of α-Synuclein , 2015, Journal of Parkinson's disease.

[13]  J. Schapansky,et al.  The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson’s disease , 2015, Neuroscience.

[14]  M. Cookson,et al.  Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease. , 2015, Human molecular genetics.

[15]  Michael J. Devine,et al.  A cell culture model for monitoring α-synuclein cell-to-cell transfer , 2015, Neurobiology of Disease.

[16]  C. van Broeckhoven,et al.  Progress in unraveling the genetic etiology of Parkinson disease in a genomic era. , 2015, Trends in genetics : TIG.

[17]  R. Vassar,et al.  Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level , 2015, Molecular Neurodegeneration.

[18]  I. Martin,et al.  LRRK2 pathobiology in Parkinson's disease , 2014, Journal of neurochemistry.

[19]  J. Winkler,et al.  Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment , 2014, Autophagy.

[20]  D. Rubinsztein,et al.  Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy , 2014, Nature Communications.

[21]  Li-Li Zuo,et al.  The impact of reactive oxygen species and genetic mitochondrial mutations in Parkinson's disease. , 2013, Gene.

[22]  P. Brundin,et al.  Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice , 2013, Acta Neuropathologica.

[23]  E. Bézard,et al.  Lysosomal impairment in Parkinson's disease , 2013, Movement disorders : official journal of the Movement Disorder Society.

[24]  Ssang-Goo Cho,et al.  Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein , 2013, Experimental & Molecular Medicine.

[25]  D. D. Di Monte,et al.  Oxidative and nitrative alpha‐synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies , 2013, Journal of neurochemistry.

[26]  David N Hauser,et al.  Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism , 2013, Neurobiology of Disease.

[27]  H. Hutter,et al.  Discoidin domain receptors guide axons along longitudinal tracts in C. elegans. , 2013, Developmental biology.

[28]  P. Brundin,et al.  What’s to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease? , 2013, Prion.

[29]  J. Trojanowski,et al.  Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice , 2012, Science.

[30]  D. Moerman Large-Scale Screening for Targeted Knockouts in the Caenorhabditis elegans Genome , 2012, G3: Genes | Genomes | Genetics.

[31]  E. Morignat,et al.  Prion-like acceleration of a synucleinopathy in a transgenic mouse model , 2012, Neurobiology of Aging.

[32]  A. Winslow,et al.  Exosomal cell-to-cell transmission of alpha synuclein oligomers , 2012, Molecular Neurodegeneration.

[33]  Michael F. N. O'Leary,et al.  Denervation-induced mitochondrial dysfunction and autophagy in skeletal muscle of apoptosis-deficient animals. , 2012, American journal of physiology. Cell physiology.

[34]  G. Silverman,et al.  A Pro-Cathepsin L Mutant Is a Luminal Substrate for Endoplasmic-Reticulum-Associated Degradation in C. elegans , 2012, PloS one.

[35]  Bianca Habermann,et al.  Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity , 2012, Nature Cell Biology.

[36]  T. Outeiro,et al.  Alpha-synuclein: from secretion to dysfunction and death , 2012, Cell Death and Disease.

[37]  A. Björklund,et al.  Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo , 2012, PloS one.

[38]  R. Nass,et al.  C. elegans as a genetic model system to identify Parkinson's disease-associated therapeutic targets. , 2012, CNS & neurological disorders drug targets.

[39]  P. Brundin,et al.  α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. , 2011, The Journal of clinical investigation.

[40]  O. Lindvall,et al.  Signs of degeneration in 12-22-year old grafts of mesencephalic dopamine neurons in patients with Parkinson's disease. , 2011, Journal of Parkinson's disease.

[41]  Maria Markaki,et al.  Modeling human diseases in Caenorhabditis elegans , 2010, Biotechnology journal.

[42]  J. Lazo,et al.  Automated High-Content Live Animal Drug Screening Using C. elegans Expressing the Aggregation Prone Serpin α1-antitrypsin Z , 2010, PloS one.

[43]  A. Björklund,et al.  Characterization of Lewy body pathology in 12‐ and 16‐year‐old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease , 2010, Movement disorders : official journal of the Movement Disorder Society.

[44]  M. Chalfie,et al.  Enhanced neuronal RNAi in C. elegans using SID-1 , 2010, Nature Methods.

[45]  Oliver Hobert,et al.  Hypoxia activates a latent circuit for processing gustatory information in C. elegans , 2010, Nature Neuroscience.

[46]  J. Kordower,et al.  Lewy body pathology in fetal grafts , 2010, Annals of the New York Academy of Sciences.

[47]  A. Cuervo,et al.  Protein degradation, aggregation, and misfolding , 2010, Movement disorders : official journal of the Movement Disorder Society.

[48]  Michael Wolff,et al.  Seeding induced by α‐synuclein oligomers provides evidence for spreading of α‐synuclein pathology , 2009, Journal of neurochemistry.

[49]  A. Meléndez,et al.  Autophagy in C. elegans. , 2009, WormBook : the online review of C. elegans biology.

[50]  Brian Spencer,et al.  Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein , 2009, Proceedings of the National Academy of Sciences.

[51]  Bradley T. Hyman,et al.  Correction: Formation of Toxic Oligomeric α-Synuclein Species in Living Cells , 2008, PLoS ONE.

[52]  R. Hauser,et al.  Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease , 2008, Nature Medicine.

[53]  Elisabet Englund,et al.  Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation , 2008, Nature Medicine.

[54]  Bradley T. Hyman,et al.  Formation of Toxic Oligomeric α-Synuclein Species in Living Cells , 2008, PloS one.

[55]  M. Nonet,et al.  Tomosyn Inhibits Synaptic Vesicle Priming in Caenorhabditis elegans , 2006, PLoS biology.

[56]  Di Chen,et al.  The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span , 2004, Development.

[57]  E. Jorgensen,et al.  UNC-11, a Caenorhabditis elegans AP180 homologue, regulates the size and protein composition of synaptic vesicles. , 1999, Molecular biology of the cell.