Interaction networks of hepatitis C virus NS4B: implications for antiviral therapy

Hepatitis C virus (HCV) is an important human pathogen infecting more than 170 million people worldwide with approximately three million new cases each year. HCV depends heavily on interactions between viral proteins and host factors for its survival and propagation. Among HCV viral proteins, the HCV non‐structural protein 4B (NS4B) has been shown to mediate virus–host interactions that are essential for HCV replication and pathogenesis and emerged as the target for anti‐HCV therapy. Here, we reviewed recent knowledge about the NS4B interaction networks with host factors and its possible regulatory mechanisms, which will both advance our understanding of the role of NS4B in HCV life cycle and illuminate potential viral and host therapeutic targets.