Atg7 cooperates with Pten loss to drive prostate cancer tumor growth

To assess the importance of autophagy in prostate cancer, Santanam et al. generated a new autochthonous genetically engineered mouse model with inducible prostate-specific deficiency in the Pten tumor suppressor and autophagy-related-7 (Atg7) gene. Atg7 deficiency produced an autophagy-deficient phenotype and delayed Pten-deficient prostate tumor progression in both castrate-naïve and castrate-resistant cancers.

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