Cutaneous leishmaniasis in the north of Italy

Temporary ectropion due to topical fluorouracil The first reported case of transient ectropion associated with topical fluorouracil chemotherapy was reported in 1994.' Havitig observed this association oti several occasions over the years, I hasten to report other documented cases of this. Case I On April 25, 1995, an 88-year-old man was seen with tnultiple actinic keratoses on the face, ears, neck, and upper chest. Topical treattnent was carried out using 5% 5fluorouracil cream b.i.d. for 3 weeks. When seen in followup 2 weeks later, ectropion of the lateral left lower eyelid was noted accotnpanied by a 5-fluorouracil reaction. Treatment was continued for another week. When next exatnined 9 weeks later the ectropion had cotnpletely resolved. Case 2 Onjatiuary 15,1996, a 75-year-old man was seen with tnultiple actinic keratoses on the face, ears, neck, and upper chest. Treatment was carried out using topical 5% 5fluorouracil cream b.i.d. for 3 weeks. When exatnined at the end of treattnent, ectropion of both lower eyelids was noted. When next examitied i month later, the ectropions had completely resolved. Case 3 Oti Jatiuary 8, 1996, a 79-year-old tiian was seen with tnultiple actinic keratoses on the face, ears, neck, and upper chest. Treatment was carried out using topical 5% 5fluorouracil cream b.i.d. When tiext examined 16 days later the patient had experienced a fierce reaction. Ectropion involving the lower eyelids was noted, and was more pronounced on the left (Fig. i). Treattnent was discotitinued. When examined 12 days later the ectropions had completely resolved (Fig. 2). The occurrence of topical fluorouracil-associated ectropion is certainly uncotnmoti. These patietits are reported to call attention to this documented association of tetnporary ectropion with this topical chemotherapy for multiple actinic keratoses, and to etnphasize the self-limited and iticotisequetitial tiature of this type of ectropion. ,.' -v