Immunohistological study on laminin in gastric cancer in relation to histological type and metastasis.

胃癌切除例214例を対象とし, formarin固定paraffin切片について, avidin-biotin peroxidase complex法によるlaminin染色を行い, 組織型および肝転移との関係について検討した. 組織型では, 高分化腺癌48.7%, 中分化腺癌29.3%, 低分化腺癌7.2%であり, 高分化な癌ほどlaminin陽性率は高かった. 低分化腺癌の陽性6例はすべて充実胞巣型であった. 肝転移との関係では, laminin陽性率は肝転移陰性例23.1%, 肝転移陽性例91.3%, 肝転移巣90.9%と肝転移例ほどlaminin陽性率が高く, 低分化腺癌の肝転移陽性4例中3例は1aminin陽性の充実胞巣型であった. 以上より, lamininは肝転移を促進し, 従来の組織型と肝転移の関係をlamininの面から解明できることを示唆した.

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