Survivability among severely injured patients who arrive at a suitable medical facility has steadily improved; however, the number of lives lost due to serious injuries prior to arrival at a hospital has changed little. This is true for civilian and military casualties. The greater the delay before the initiation of definitive therapy, the more pronounced is the impact on survival for the critically injured, whether delays are due to failure of accurate diagnosis, lack of advanced training, or logistics issues for transport. Last year alone in the United States over 43,000 lives were lost due to injuries received in civilian motor vehicle crashes (MVCs). This study examines a novel approach to reduce pre-hospital mortality using existing capabilities within an Advanced Traffic Management System (ATMS). The TransGuide-LifeLink project provides telemedicine links between emergency medical services (EMS) ambulances and trauma centers. This paper reports on initial research conducted by a unique team of physicians, paramedics, and engineers from U.S. military, municipal EMS, state departments of transportation (DOT), and private research organizations. The objective of this research was to assess the feasibility of using an ATMS for real-time, remote, physician-directed, diagnostic ultrasound imaging during pre-hospital patient transport. The results of this work indicate that this combination of technologies and medical capabilities can operate successfully to the benefit of seriously injured or ill patients and their care providers. These and other programs facilitated by synergistic relationships between public safety, medical, and transportation technologies have the potential for developing and fielding advances that can save lives in civilian medical emergencies, mass casualty incidents, and armed forces combat casualty care.