The Application of a Desktop NMR Spectrometer in Drug Analysis

A desktop NMR spectrometer was used to qualitatively analyze samples in drug-related cases in order to enhance the accuracy of the results and identify new drugs. Twelve known drugs and their derivatives were used to establish the parameters, conditions, and procedures for the methods and validate the feasibility and reliability of the methods. First, 1-D and 2-D NMR data for these 12 drugs and their derivatives were obtained in detail using a 600-MHz NMR spectrometer to create a data library. Next, some of these 12 drugs were analyzed using a Picospin 80 MHz desktop NMR spectrometer to set up the analytical procedure and method. With the procedure and method established, real case samples were analyzed and the data were compared to those obtained by a standard method. The results indicate that the desktop NMR spectrometer is a reliable and promising approach that can be used in criminology to quickly identify whether or not samples contain illegal drugs.

[1]  M Chiarotti,et al.  Comparative analysis of heroin and cocaine seizures. , 1999, Journal of chromatography. B, Biomedical sciences and applications.

[2]  Pang Zibo,et al.  Characterization of molecular structure of DAST via NMR spectroscopy , 2016 .

[3]  David R Morello,et al.  Signature Profiling and Classification of Illicit Heroin by GC‐MS Analysis of Acidic and Neutral Manufacturing Impurities , 2010, Journal of forensic sciences.

[4]  C. Groombridge.  NMR Spectroscopy in Forensic Science , 1996 .

[5]  P. Lillsunde,et al.  A comparison between on-site immunoassay drug-testing devices and laboratory results. , 2001, Forensic science international.

[6]  Xianghe Meng,et al.  Determination of Nonprotein Nitrogen Components of Milk by Nuclear Magnetic Resonance , 2016 .

[7]  S. Béni,et al.  Sulfate esters of morphine derivatives: synthesis and characterization. , 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[8]  N. Culeddu,et al.  Screening Method for Five Commonly Used Amphetamines in Urine by NMR Spectroscopy , 2014 .

[9]  H. M. Maher,et al.  GC-MS and GC-IRD studies on dimethoxyamphetamines (DMA): regioisomers related to 2,5-DMA. , 2009, Forensic science international.

[10]  M. Wilson,et al.  High-resolution solid state 13C nuclear magnetic resonance spectra of 3,4-methylenedioxyamphetamine hydrochloride and related compounds and their mixtures with lactose. , 2000, Solid state nuclear magnetic resonance.

[11]  D. Burns,et al.  Determination of 3,4-methylenedioxyamphetamine analogues (“ecstasy”) by proton nuclear magnetic resonance spectrometry , 1997 .

[12]  I. S. Blagbrough,et al.  ¹H, ¹³C, ¹⁵N HMBC, and ¹⁹F NMR spectroscopic characterisation of seized flephedrone, cut with benzocaine. , 2015, Journal of pharmaceutical and biomedical analysis.

[13]  B. Tarasiuk,et al.  New organic single crystal of (benzylthio)acetic acid: Synthesis, crystal structure, spectroscopic (ATR-FTIR, 1H and 13C NMR) and thermal characterization , 2016 .

[14]  C. Trignano,et al.  Cross-reactivities of 39 new amphetamine designer drugs on three abuse drugs urinary screening tests , 2013, Forensic Toxicology.

[15]  P. Hays.  Proton nuclear magnetic resonance spectroscopy (NMR) methods for determining the purity of reference drug standards and illicit forensic drug seizures. , 2005, Journal of forensic sciences.

[16]  M. Elipe.  Advantages and disadvantages of nuclear magnetic resonance spectroscopy as a hyphenated technique , 2003 .

[17]  M. Malet‐Martino,et al.  Characterization of heroin samples by 1H NMR and 2D DOSY 1H NMR. , 2014, Forensic science international.

[18]  Xuan Luo,et al.  Chemical properties and antioxidant activity of a water-soluble polysaccharide from Dendrobium officinale. , 2016, International journal of biological macromolecules.

[19]  Mikhail E. Elyashberg,et al.  Identification and structure elucidation by NMR spectroscopy , 2015 .

[20]  I. Ekiel,et al.  High‐resolution proton magnetic resonance spectra of morphine and its three O‐acetyl derivatives , 1987 .

[21]  Young‐Wun Kim,et al.  Quantitative analysis of cyclic dimer fatty acid content in the dimerization product by proton NMR spectroscopy. , 2015, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[22]  G. Jackson,et al.  STRUCTURAL ASSIGNMENT OF THE OPIUM ALKALOID, CODEINE VIA 2D NMR TECHNIQUES , 1997 .