D-Glucuronic Acid Coated Gd(IO3)3·2H2O Nanomaterial as a Potential T1 MRI-CT Dual Contrast Agent

To date, only a few nanosystems have been investigated as T1 MRI-CT dual contrast agents. The T1 MRI-CT dual functionality of a material depends on its longitudinal water-proton relaxivity (r1) and X-ray absorption strength. We explored Gd(IO3)3·2H2O nanomaterial because Gd is the most powerful element for T1 MRI contrast agents, and both Gd and I absorb X-ray radiation; Gd absorbs X-ray radiation ca. 2.5 times more strongly than I. D-Glucuronic acid coated Gd(IO3)3·2H2O nanomaterial showed a very large r1 of 52.3 s–1 mM–1 (r2/r1 = 1.21), which could be ascribed to hydrated water molecules in the lattice. Its X-ray absorption intensity was also stronger than those of commercial molecular iodine CT contrast agents. This result clearly suggests that D-glucuronic acid coated Gd(IO3)3·2H2O nanomaterial is a potential T1 MRI-CT dual contrast agent.

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