Prospective Randomised Controlled Trial Comparing Treatment Efficacy and Tolerance of Picosecond Alexandrite Laser with a Diffractive Lens Array and Triple Combination Cream in Female Asian Patients with Melasma.

Recent evidence suggests melasma to be a photoaging disorder. Triple combination creams (TCC: fluocinolone acetonide 0.01%, hydroquinone 4% and tretinoin 0.05%) remain the gold standard treatment. Picosecond alexandrite laser treatment using a diffractive lens array (DLA) has been identified to be effective for improving photoaging conditions.

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