Karyotypic features of malignant tumors of the nasal cavity and paranasal sinuses

Cytogenetic analysis of short‐term cultures from 6 tumors of the nasal cavity and paranasal sinuses—one esthesioneuroblas‐toma, 2 adenocarcinomas and 3 squamous‐cell carcinomas (SCC)—revealed clonal chromosome aberrations in all cases. The esthesioneuroblastoma had a complex hyperdiploid karyotype. None of the aberrations was similar to those previously described in short‐term cultures or established cell lines from esthesioneuroblastomas. The 2 adenocarcinomas had complex karyotypic changes, which in both cases included rearrangements of bands 9p22 and 14q11. One SCC had 5 unrelated pseudodiploid clones, I displayed a highly complex karyotype, including rearrangement of band 11 q 13, and I had simple karyotypic changes with loss of 6q material and gain of 3q. These findings are similar to those described in head‐and‐neck SCC at other sites.