Distribution Analyses of Acquired Melanocytic Naevi on the Trunk

Acquired melanocytic naevi (AMN) are a well-known risk factor for the development of melanoma. Whereas previous studies have reviewed AMN distributions on individual body sites, the clinical distribution of AMN on the adult trunk has not been thoroughly investigated. We studied 40 participants with 1,282 naevi >5 mm, of which 781 were located on the trunk. Remarkably, 70% of these truncal naevi were located on the back and we produced a continuous mathematical description of decreasing naevus frequency moving dorsolaterally from the back midline. Furthermore we found that for both sexes the mean naevus size was larger on the front as well as on the lower trunk. This distinct pattern, whilst probably being unwritten knowledge (in the dermatology domain), has not been discussed before.

[1]  H. Soyer,et al.  Quantifying the orientation of acquired melanocytic nevi on the back. , 2012, Archives of dermatology.

[2]  J. Aitken,et al.  Body‐site distribution of skin cancer, pre‐malignant and common benign pigmented lesions excised in general practice , 2011, The British journal of dermatology.

[3]  A. Marghoob,et al.  Frequency of dermoscopic nevus subtypes by age and body site: a cross-sectional study. , 2011, Archives of dermatology.

[4]  T. Hirobe How are proliferation and differentiation of melanocytes regulated? , 2011, Pigment cell & melanoma research.

[5]  T. Byers,et al.  Effect of hair color and sun sensitivity on nevus counts in white children in Colorado. , 2010, Journal of the American Academy of Dermatology.

[6]  S. Krengel,et al.  Clinical and epidemiological aspects of subtypes of melanocytic nevi (Flat nevi, Miescher nevi, Unna nevi). , 2010, Dermatology online journal.

[7]  M. Weinstock,et al.  Study of Nevi in Children (SONIC): baseline findings and predictors of nevus count. , 2008, American journal of epidemiology.

[8]  D. VivianaZemelman,et al.  Análisis de la densidad y distribución anatómica de nevos melanocíticos adquiridos, en adolescentes del estrato socioeconómico bajo de Santiago de Chile , 2008 .

[9]  Howard Y. Chang,et al.  A dermal HOX transcriptional program regulates site-specific epidermal fate. , 2008, Genes & development.

[10]  C. Valenzuela,et al.  [Body distribution and density of acquired melanocytic nevi in adolescents of low socioeconomic status of Santiago, Chile]. , 2008, Revista medica de Chile.

[11]  L. Naldi,et al.  Nevus count on specific anatomic sites as a predictor of total body count: a survey of 3,406 children from Italy. , 2007, American journal of epidemiology.

[12]  I. Zalaudek,et al.  Dermoscopy insights into nevogenesis: "Abtropfung" vs "Hochsteigerung". , 2007, Archives of dermatology.

[13]  J. Bulliard,et al.  Detailed site distribution of melanoma and sunlight exposure: aetiological patterns from a Swiss series. , 2006, Annals of oncology : official journal of the European Society for Medical Oncology.

[14]  J. Lange From Melanocytes to Melanoma: The Progression to Malignancy , 2007 .

[15]  L. Naldi,et al.  Anthropometric measures and risk of cutaneous malignant melanoma: a case–control study from Italy , 2006, Melanoma research.

[16]  D. Whiteman,et al.  Melanocytic nevi in very young children: the role of phenotype, sun exposure, and sun protection. , 2011, Journal of the American Academy of Dermatology.

[17]  K. Yoshikawa,et al.  Mesenchymal-epithelial interactions in the skin: aiming for site-specific tissue regeneration. , 2005, Journal of dermatological science.

[18]  C. Garbe,et al.  Risk factors of incident melanocytic nevi: A longitudinal study in a cohort of 1,232 young German children , 2005, International journal of cancer.

[19]  A. Marghoob,et al.  The Framingham school nevus study: a pilot study. , 2004, Archives of dermatology.

[20]  G. Severi,et al.  Number and size of nevi are influenced by different sun exposure components: implications for the etiology of cutaneous melanoma (Belgium, Germany, France, Italy) , 2003, Cancer Causes & Control.

[21]  D. Whiteman,et al.  Prevalence and anatomical distribution of naevi in young Queensland children , 2003, International journal of cancer.

[22]  C. Garbe,et al.  Acquired melanocytic nevi as risk factor for melanoma development. A comprehensive review of epidemiological data. , 2003, Pigment cell research.

[23]  S. Harrison,et al.  The Eastern Australian Childhood Nevus Study: site differences in density and size of melanocytic nevi in relation to latitude and phenotype. , 2003, Journal of the American Academy of Dermatology.

[24]  G. Severi,et al.  The body site distribution of melanocytic naevi in 6–7 year old European children , 2001, Melanoma research.

[25]  S. Walter,et al.  Do larger people have more naevi? Naevus frequency versus naevus density. , 2000, International journal of epidemiology.

[26]  P. Buettner,et al.  Body-site distribution of melanocytic nevi in young Australian children. , 1999, Archives of dermatology.

[27]  C. Garbe,et al.  Increase of melanocytic nevus counts in children during 5 years of follow-up and analysis of associated factors. , 1996, Archives of dermatology.

[28]  D. English,et al.  Melanocytic nevi in children. I. Anatomic sites and demographic and host factors. , 1994, American journal of epidemiology.

[29]  V. Siskind,et al.  Melanocytic nevi in schoolchildren in Queensland. , 1989, Journal of the American Academy of Dermatology.

[30]  E. Holly,et al.  THE DISTRIBUTION OF MELANOCYTIC NAEVI IN MELANOMA PATIENTS AND CONTROL SUBJECTS , 1989, The Australasian journal of dermatology.

[31]  E. Nicholls Development and elimination of pigmented moles, and the anatomical distribution of primary malignant melanoma , 1973, Cancer.