FGF17 is an autocrine prostatic epithelial growth factor and is upregulated in benign prostatic hyperplasia

Fibroblast growth factors (FGFs) are known to play an important role in the growth of prostatic epithelial cells. Benign prostatic hyperplasia (BPH) is characterized by increased epithelial and stromal proliferation within the transition zone of the prostate. FGF2, FGF7, and FGF9 are expressed in BPH tissue but expression of FGF17 has not been previously characterized in human prostate tissue.

[1]  M. Ittmann,et al.  Role of fibroblast growth factor receptor signaling in prostate cancer cell survival. , 2001, Journal of the National Cancer Institute.

[2]  Nobuyuki Itoh,et al.  Fibroblast growth factors , 2001, Genome Biology.

[3]  M. Ittmann,et al.  FGF‐10 Is expressed at low levels in the human prostate , 2000, The Prostate.

[4]  M. Ittmann,et al.  Increased expression of fibroblast growth factor 6 in human prostatic intraepithelial neoplasia and prostate cancer. , 2000, Cancer research.

[5]  A. Thomson,et al.  Prostatic growth and development are regulated by FGF10. , 1999, Development.

[6]  M. Ittmann,et al.  FGF7 and FGF2 are increased in benign prostatic hyperplasia and are associated with increased proliferation. , 1999, The Journal of urology.

[7]  M. Ittmann,et al.  FGF9 is an autocrine and paracrine prostatic growth factor expressed by prostatic stromal cells , 1999, Journal of cellular physiology.

[8]  M. Ittmann,et al.  Alterations in expression of basic fibroblast growth factor (FGF) 2 and its receptor FGFR-1 in human prostate cancer. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

[9]  C. MacArthur,et al.  Genomic structure, mapping, activity and expression of fibroblast growth factor 17 , 1999, Mechanisms of Development.

[10]  D. Neal,et al.  FGF8 over-expression in prostate cancer is associated with decreased patient survival and persists in androgen independent disease , 1999, Oncogene.

[11]  D. Duan,et al.  Identification and characterization of a novel member of the fibroblast growth factor family , 1998, The European journal of neuroscience.

[12]  M. Konishi,et al.  Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain. , 1998, Biochemical and biophysical research communications.

[13]  M. Ittman,et al.  Expression of fibroblast growth factors (FGFs) and FGF receptors in human prostate. , 1997, The Journal of urology.

[14]  C. MacArthur,et al.  Receptor Specificity of the Fibroblast Growth Factor Family* , 1996, The Journal of Biological Chemistry.

[15]  D. Neal,et al.  Over-expression of fibroblast growth factor-8 in human prostate cancer. , 1996, Oncogene.

[16]  E. Shapiro,et al.  Regional concentration of basic fibroblast growth factor in normal and benign hyperplastic human prostates. , 1995, The Journal of urology.

[17]  J. McNeal,et al.  Differential cytokeratin expression in normal, hyperplastic and malignant epithelial cells from human prostate. , 1990, The Journal of urology.

[18]  R J Glynn,et al.  The development of benign prostatic hyperplasia among volunteers in the Normative Aging Study. , 1985, American journal of epidemiology.