Case report. Aplastic anemia. Effect of antithymocyte globulin on erythroid colony formation.

Department of Laboratory Hematology and Blood Banking Acquired aplastic anemia is a diverse hematopoietic disorder in which pancytopenia is associated with extremely reduced bone marrow cellularity. Although certain drugs, organic solvents, and viral infections have been found to antedate this disorder, an etiologic agent cannot be identified in approximately 50% of patients. In cases where a toxic agent or infection can be implicated in causing the disease, the exact pathogenesis is unknown. Experimental and clinical evidence has been accumulating to show that in some cases of acquired aplastic anemia, a population of lymphocytes is present which can suppress normal hematopoiesis. Based on these findings, several clinical trials have been initiated using antithymocyte globulin (ATG) as a therapeutic agent. We report the results of a study of bone marrow erythroid colony formation in a patient with idiopathic aplastic anemia before and after ATG therapy.

[1]  FAILURE OF SYNGENEIC BONE-MARROW GRAFT WITHOUT PRECONDITIONING IN POST-HEPATITIS MARROW APLASIA THE ROYAL MARSDEN HOSPITAL BONE-MARROW TRANSPLANTATION TEAM Royal Marsden Hospital, Sutton, Surrey , 1977, The Lancet.

[2]  R. Hoffman,et al.  Suppression of erythroid-colony formation by lymphocytes from patients with aplastic anemia. , 1977, The New England journal of medicine.

[3]  J. Hansen,et al.  Aplastic anemia: presence in human bone marrow of cells that suppress myelopoiesis. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[4]  B. Speck,et al.  Autologous marrow reconstitutions in severe aplastic anaemia after ALG pretreatment and HL-A semi-incompatible bone marrow cell transfusion. , 1976, Acta haematologica.

[5]  R. Good,et al.  Aplastic anaemia: Evidence for an immunological mechanism. , 1976, Lancet.

[6]  R. Storb,et al.  Recovery from aplastic anemia following attempted marrow transplantation. , 1976, Experimental hematology.

[7]  F. Takaku,et al.  Damaged DNA in lymphocytes of aplastic anemia. , 1975, Blood.

[8]  G. Corrigan.  An autopsy survey of aplastic anemia. , 1974, American journal of clinical pathology.

[9]  F. Sieber,et al.  Erythroid colony formation in cultures of mouse and human bone marrow: Analysis of the requirement for erythropoietin by gel filtration and affinity chromatography on agarose‐concanavalin A , 1974, Journal of cellular physiology.

[10]  J. Till,et al.  Interacting cell populations affecting granulopoietic colony formation by normal and leukemic human marrow cells. , 1973, Blood.

[11]  R. Lynch,et al.  Drug-induced aplastic anemia. , 1973, Seminars in hematology.

[12]  R Revol Núñez,et al.  [Aplastic anemia]. , 1970, Archivos Argentinos de Pediatria.